Supplementary Data from Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer

Autor: Philip W. Howard, John A. Hartley, Mary McFarlane, Luke A. Masterson, Kathryn Ball, Conor S. Barry, Lauren Adams, Rhiannon Beard, K. Phin Chooi, Gyoung-Dong Kang, Ian Hutchinson, Jitka Riedl, Kathleen Santos, Balakumar Vijayakrishnan, Shameen Afif-Rider, Neki Patel, Kathryn Pugh, Stephen J. Gregson

Supplementary Data from Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0808e71ffb8fdea67b4acfbd119e387a
https://doi.org/10.1158/1535-7163.22523461.v1

Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs

Autor: Andy Stucki, Edward W. Tate, Rhiannon Beard, Gabrielle Py, Muriel Schmitt, Antony D. Gee, Christophe Grundschober

Publikováno v: Beard, R, Stucki, A, Schmitt, M, Py, G, Grundschober, C, Gee, A & Tate, E 2018, ' Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs ', Bioorganic and Medicinal Chemistry . https://doi.org/10.1016/j.bmc.2018.03.019

Oxytocin (OT) is an exciting potential therapeutic agent, but it is highly sensitive to modification and suffers extensive degradation at elevated temperature and in vivo. Here we report studies towards OT analogs with favorable selectivity, affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b540c7ee40b7ca53feda3d015e277de6
https://doi.org/10.1016/j.bmc.2018.03.019

Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension

Autor: Balakumar Vijayakrishnan, Qing Li, Philip Howard, M. Jack Borrok, Arnaud C. Tiberghien, Keith W Rickert, Allison M. Barrett, Kevin L Allen, Changshou Gao, Ping Tsui, William Dall'acqua, R Jim Christie, Jay Harper, Marcello Marelli, Rhiannon Beard, Herren Wu

Publikováno v: Bioconjugate chemistry. 30(4)

Despite some clinical success with antibody-drug conjugates (ADCs) in patients with solid tumors and hematological malignancies, improvements in ADC design are still desirable due to the narrow therapeutic window of these compounds. Tumor-targeting a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1daefaf386f5538098578d7d47f70b56
https://pubmed.ncbi.nlm.nih.gov/30912649

High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo

Autor: Edward W. Tate, Rhiannon Beard, Christophe Grundschober, Nisha Singh, Antony D. Gee

Publikováno v: Beard, R, Singh, N, Grundschober, C, Gee, A D & Tate, E W 2018, ' High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo ', CHEMICAL COMMUNICATIONS-ROYAL SOCIETY OF CHEMISTRY, vol. 54, no. 58, pp. 8120-8123 . https://doi.org/10.1039/C8CC01400K

A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cf1a0e2d1f9fcf9cd076cf0619ea4b
https://kclpure.kcl.ac.uk/en/publications/5d02860c-0054-4963-be10-1448b4640e19