Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Rhiannon, David"'
Autor:
David B. Chou, Brooke A. Furlong, Ryan R. Posey, Christos Kyprianou, Lucy R. O’Sullivan, Rhiannon David, Suzanne J. Randle, Urszula M. Polanska, Jon Travers, Jelena Urosevic, John N. Hutchinson, Jianwei Che, Anna M. Howley, Robert P. Hasserjian, Rachelle Prantil-Baun, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Patients treated with Aurora kinase inhibitors experience dose-limiting neutropenia while other cytopenias are rare. Here, Chou et al. show that this cell-type specific side effect is partly explained by loss of drug efflux pump expression during neu
Externí odkaz:
https://doaj.org/article/30b138eaa22049aea33459bc0a7f87f2
Autor:
Jonathan Cairns, Emilyanne Leonard, Kainat Khan, Conor Parks, Gareth Maglennon, Bairu Zhang, Stanley E. Lazic, Lorna Ewart, Rhiannon David
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Microphysiological systems (MPS; organ-on-a-chip) aim to recapitulate the 3D organ microenvironment and improve clinical predictivity relative to previous approaches. Though MPS studies provide great promise to explore treatment options
Externí odkaz:
https://doaj.org/article/1257d15b6da04bb7825cb361187ba6d5
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Micronucleus (MN) assessment is a valuable tool in safety assessment. However, several compounds are positive in the in vivo bone marrow (BM) MN assay but negative in vitro, reflecting that BM complexity is not recapitulated in vitro. Import
Externí odkaz:
https://doaj.org/article/a0d2a586f0fc4f4e9d2b85c530eb68b8
Autor:
Uwe Marx, Enrico Accastelli, Rhiannon David, Hendrik Erfurth, Leopold Koenig, Roland Lauster, Anja Patricia Ramme, Petra Reinke, Hans-Dieter Volk, Annika Winter, Eva-Maria Dehne
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
The first concepts for reproducing human systemic organismal biology in vitro were developed over 12 years ago. Such concepts, then called human- or body-on-a-chip, claimed that microphysiological systems would become the relevant technology platform
Externí odkaz:
https://doaj.org/article/749322213ef54553894134ac5bc2c221
Autor:
Alexandra E. Butler, Vimal Ramachandran, Thomas Keith Cunningham, Rhiannon David, Nigel J. Gooderham, Manasi Benurwar, Soha R. Dargham, Shahina Hayat, Thozhukat Sathyapalan, S Hani Najafi-Shoushtari, Stephen L. Atkin
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
BackgroundSmall noncoding microRNA (miRNA) have regulatory functions in polycystic ovary syndrome (PCOS) that differ to those in women without PCOS. However, little is known about miRNA expression in women with PCOS who are not insulin resistant (IR)
Externí odkaz:
https://doaj.org/article/54abdaeafe024e7bbec502b03cb39cf4
Autor:
Alexandra E. Butler, Vimal Ramachandran, Thozhukat Sathyapalan, Rhiannon David, Nigel J. Gooderham, Manasi Benurwar, Soha R. Dargham, Shahina Hayat, S. Hani Najafi-Shoushtari, Stephen L. Atkin
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/2b07b776198b44fdaabc23159ccd0166
Autor:
Alexandra E. Butler, Vimal Ramachandran, Thozhukat Sathyapalan, Rhiannon David, Nigel J. Gooderham, Manasi Benurwar, Soha R. Dargham, Shahina Hayat, S. Hani Najafi-Shoushtari, Stephen L. Atkin
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Background: Despite several authors who have hypothesized that alterations of small noncoding RNAs (miR) are implicated in the etiopathogenesis of polycystic ovarian syndrome (PCOS), contrasting findings have been reported so far. Discrepancies in bo
Externí odkaz:
https://doaj.org/article/aeec324ce74642e2b8cc6c2c12c66b7e
Autor:
Petar Pop-Damkov, Rhiannon David, Arianna Rech, Lucy R. O’Sullivan, Susan Marquez, Brooke A. Furlong, Douglas Ferguson, Kasiani C. Myers, Amanda Jiang, Liliana Moreira Teixeira, Oren Levy, Youngjae Choe, Özge Vargel Bölükbaşı, David B. Chou, Richard M. Novak, Olga K. Weinberg, Carl D. Novina, Robert P. Hasserjian, Lorna Ewart, Yuka Milton, Cailin E. Joyce, Viktoras Frismantas, Elizabeth Calamari, Sasan Jalili-Firoozinezhad, Rachelle Prantil-Baun, Donald E. Ingber, Alexander MacDonald, Akiko Shimamura, Carlos F. Ng
Publikováno v:
Nature biomedical engineering
The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show that a vascularized human BM-on-a-chip (BM chip) supports the differentiat
Autor:
Xiaoting, Wang, Anna K, Kopec, Mark, Collinge, Rhiannon, David, Christian, Grant, Rhiannon N, Hardwick, Aaron, Navratil, Nirav, Patel, Wendy, Rowan, Nikki, Marshall
Publikováno v:
ALTEX.
Immune responses are heavily involved in the regulation and pathogenesis of human diseases, including infectious diseases, inflammatory and autoimmune conditions, cancer, neurological disorders and cardiometabolic syndromes. The immune system has bee
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Micronucleus (MN) assessment is a valuable tool in safety assessment. However, several compounds are positive in the in vivo bone marrow (BM) MN assay but negative in vitro, reflecting that BM complexity is not recapitulated in vitro. Importantly, th