Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rhianna E. Lee"'
Autor:
Rita M. Meganck, Caitlin E. Edwards, Michael L. Mallory, Rhianna E. Lee, Hong Dang, Alexis B. Bailey, Jason A. Wykoff, Samuel C. Gallant, Deanna R. Zhu, Boyd L. Yount, Takafumi Kato, Kendall M. Shaffer, Satoko Nakano, Anne Marie Cawley, Vishwaraj Sontake, Jeremy R. Wang, Robert S. Hagan, Melissa B. Miller, Purushothama Rao Tata, Scott H. Randell, Longping V. Tse, Camille Ehre, Kenichi Okuda, Richard C. Boucher, Ralph S. Baric
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114076- (2024)
Summary: The severe acute respiratory syndrome coronavirus 2 pandemic is characterized by the emergence of novel variants of concern (VOCs) that replace ancestral strains. Here, we dissect the complex selective pressures by evaluating variant fitness
Externí odkaz:
https://doaj.org/article/f8f7061e966c4c31ad0d17d536355449
Autor:
Andrew Berical, Rhianna E. Lee, Junjie Lu, Mary Lou Beermann, Jake A. Le Suer, Aditya Mithal, Dylan Thomas, Nicole Ranallo, Megan Peasley, Alex Stuffer, Katherine Bukis, Rebecca Seymour, Jan Harrington, Kevin Coote, Hillary Valley, Killian Hurley, Paul McNally, Gustavo Mostoslavsky, John Mahoney, Scott H. Randell, Finn J. Hawkins
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Hundreds of mutations in the gene CFTR lead to cystic fibrosis and represent a challenge to developing therapeutics. Here, authors demonstrate the ability of airway cells derived from human iPSCs to model genotype-specific CFTR function as well as ph
Externí odkaz:
https://doaj.org/article/850dff2dec12496d9eba80d2cebdd541
Autor:
Rhianna E. Lee, Catherine A. Lewis, Lihua He, Emily C. Bulik-Sullivan, Samuel C. Gallant, Teresa M. Mascenik, Hong Dang, Deborah M. Cholon, Martina Gentzsch, Lisa C. Morton, John T. Minges, Jonathan W. Theile, Neil A. Castle, Michael R. Knowles, Adam J. Kimple, Scott H. Randell
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
The vast majority of people with cystic fibrosis (CF) are now eligible for CF transmembrane regulator (CFTR) modulator therapy. The remaining individuals with CF harbor premature termination codons (PTCs) or rare CFTR variants with limited treatment
Externí odkaz:
https://doaj.org/article/0342006f024949bb976f55db34ef1e17
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the life-limiting hereditary disease, cystic fibrosis (CF). Decreased or absent functional CFTR protein in airway epithelial cells leads to abnormally viscous mucu
Externí odkaz:
https://doaj.org/article/8d62fda03272491e93e1ebda517c9df7
Autor:
Rhianna E. Lee, Ian C. McDowell, Scott H. Randell, Nikita Dalal, Ami M. Kabadi, Leah Machlin, Timothy E. Reddy, Nirav N. Shah, Lauren Drowley
Publikováno v:
J Cyst Fibros
Background Mechanisms governing the diversity of CFTR gene expression throughout the body are complex. Multiple intronic and distal regulatory elements are responsible for regulating differential CFTR expression across tissues. Methods Drawing on pub
Autor:
Rhianna E. Lee, Teresa M. Mascenik, Sidra C. Major, Catherine A. Lewis, James E. Bear, Raymond J. Pickles, Scott H. Randell
Cell therapy is a potential treatment for cystic fibrosis (CF). However, cell engraftment into the airway epithelium is challenging. Here, we model cell engraftmentin vitrousing the air-liquid interface (ALI) culture system by injuring well-different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6b77ee35e3508cae13e80e850e48c79
https://doi.org/10.1101/2022.11.14.516213
https://doi.org/10.1101/2022.11.14.516213
Autor:
Wanda K. O'Neal, Rhianna E. Lee, Teresa M. Mascenik, Takanori Asakura, Hong Dang, Lisa C. Morton, Barbara R. Grubb, Hirotoshi Matsui, Martina Gentzsch, Richard C. Boucher, Carlton W Anderson, Kenichi Okuda, Gang Chen, Purushothama Rao Tata, Yvonne K. O’Neal, Satoko Nakano, Takahide Nagase, Yoshihiko Kobayashi, Michael Chua, Selene Margarita Barbosa Cardenas, Nancy L. Quinney, John C. Olsen, Andrew J. Ghio, Gianni Carraro, Caroline E Minnick, Lawrence E. Ostrowski, Rodney C. Gilmore, Takafumi Kato, Scott H. Randell, Barry R. Stripp, Weining Yin
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 203:1275-1289
Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF] transmembrane conductance regulator) is required for precision medicine therapies for CF. However, a full ...
Autor:
Rhianna E. Lee, Hong Dang, Zachary H Boggs, Teresa M. Mascenik, Robert Tarran, Catherine A. Lewis, Sean M. Miller, Scott H. Randell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Cystic fibrosis (CF) is caused by loss-of-function mutations in the CFTR (CF transmembrane regulator) gene. Pharmacologic therapies directed at CFTR have been developed but are not effective for mutations that result in little or no mRNA or protein e
Autor:
Lihua He, Hong Dang, Scott H. Randell, Rhianna E. Lee, Minges Jt, Lisa C. Morton, Castle Na, Adam J. Kimple, Theile Jw, Michael R. Knowles, Catherine A. Lewis, Gallant Sc, Teresa M. Mascenik
With the approval of elexacaftor/tezacaftor/ivacaftor (trade name Trikafta), the vast majority of people with cystic fibrosis (CF) are eligible for CF transmembrane conductance regulator (CFTR) modulator therapy. Remaining individuals have premature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2de0779d2aa54a95f1251c245e574cd9
https://doi.org/10.1101/2021.09.28.462149
https://doi.org/10.1101/2021.09.28.462149
Autor:
Scott H. Randell, Andrew Berical, K. Coote, Mostovslavsky G, Paul McNally, Peasley M, Mary Lou Beermann, LeSeur Ja, Junjie Lu, N. Ranallo, Dylan D. Thomas, Rhianna E. Lee, Finn Hawkins, A. Stuffer, John Mahoney, Killian Hurley, J. Harrington, Aditya Mithal
Cystic fibrosis (CF) is a monogenic lung disease caused by dysfunction of the cystic fibrosis transmembrane regulator (CFTR) anion channel, resulting in significant morbidity and mortality. The progress in elucidating the role of the CFTR channel usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1f3afe5ada9e3505b682426c0505ab1
https://doi.org/10.1101/2021.06.21.448578
https://doi.org/10.1101/2021.06.21.448578