Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries

Autor: Brandon B. Boland, Rhianna C. Laker, Siobhan O'Brien, Sadichha Sitaula, Isabelle Sermadiras, Jens Christian Nielsen, Pernille Barkholt, Urmas Roostalu, Jacob Hecksher-Sørensen, Sara Rubek Sejthen, Ditte Dencker Thorbek, Arthur Suckow, Nicole Burmeister, Stephanie Oldham, Sarah Will, Victor G. Howard, Benji M. Gill, Philip Newton, Jacqueline Naylor, David C. Hornigold, Jotham Austin, Louise Lantier, Owen P. McGuinness, James L. Trevaskis, Joseph S. Grimsby, Christopher J. Rhodes

Publikováno v: Molecular Metabolism, Vol 55, Iss , Pp 101392- (2022)

Objective: Obesity-linked type 2 diabetes (T2D) is a worldwide health concern and many novel approaches are being considered for its treatment and subsequent prevention of serious comorbidities. Co-administration of glucagon like peptide 1 (GLP-1) an

Externí odkaz: https://doaj.org/article/b325ef86371a42baa07ae1549ba9e3b0

Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency

Autor: Zhen Yan, Ana Kronemberger, Jay Blomme, Jarrod A. Call, Hannah M. Caster, Renata O. Pereira, Henan Zhao, Vitor U. de Melo, Rhianna C. Laker, Mei Zhang, Vitor A. Lira

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract Autophagy is stimulated by exercise in several tissues; yet the role of skeletal and cardiac muscle-specific autophagy on the benefits of exercise training remains incompletely understood. Here, we determined the metabolic impact of exercise

Externí odkaz: https://doaj.org/article/74eacc2c370844829f2d479d16461e8f

Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development

Autor: Christian Garde, Rhianna C. Laker, Ali Altıntaş, Juleen R. Zierath, Romain Barrès

Publikováno v: Altıntaş, A, Laker, R C, Garde, C, Barrès, R & Zierath, J R 2020, ' Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development ', Epigenomics, vol. 12, no. 8, pp. 701-713 . https://doi.org/10.2217/epi-2019-0391

Aim: Innate circadian rhythms are critical for optimal tissue-specific functions, including skeletal muscle, a major insulin-sensitive tissue responsible for glucose homeostasis. We determined whether transcriptional oscillations are associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b869438c58d47bdae3c08cced87124d
https://doi.org/10.2217/epi-2019-0391

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy

Autor: Ruofan Cao, David F. Kashatus, Eric M. Desjardins, Anna S. Nichenko, Jitendra Gautam, Matthew H. Brisendine, Huayu Shang, Hannah R. Spaulding, D. Grahame Hardie, Joshua C. Drake, Yuntian Guan, Horst Wallrabe, Mei Zhang, Maya V. Dorn, Aloka B. Bandara, Rebecca J. Wilson, Matthew J. Wolf, Michael Wong, Jennifer A. Kashatus, Gregory R. Steinberg, Kian Huang, Clint L. Miller, Simon A. Hawley, George J. Christ, Wenqing Shen, Poonam Sharma, Paul A. Chang, Zhen Yan, Ammasi Periasamy, Alexander S. Young, Rhianna C. Laker

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Here, we present unequivocal evidence of physical association of AMPK holoenzymes with mitochondrial reticulum (mitoAMPK) across multiple mouse tissues with evidence of conservation in human skeletal muscle and heart. We demonstrate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd6cacaed2ee2763e46a56be4eb882
https://hdl.handle.net/10919/107452

Ablation of DNA-methyltransferase 3A in skeletal muscle does not affect energy metabolism or exercise capacity

Autor: Brendan Deeney, Lewin Small, Rhianna C. Laker, Lars R. Ingerslev, Romain Barrès, Alain Carrié, Philippe Couvert, Ann Normann Hansen, Eleonora Manitta

Publikováno v: PLoS Genetics, Vol 17, Iss 1, p e1009325 (2021)
PLoS Genetics
PLoS Genetics, 2021, 17 (1), pp.e1009325. ⟨10.1371/journal.pgen.1009325⟩
PLoS Genetics, Public Library of Science, 2021, 17 (1), pp.e1009325. ⟨10.1371/journal.pgen.1009325⟩
Small, L, Ingerslev, L R, Manitta, E, Laker, R C, Hansen, A N, Deeney, B, Carrie, A, Couvert, P & Barres, R 2021, ' Ablation of DNA-methyltransferase 3A in skeletal muscle does not affect energy metabolism or exercise capacity ', PLOS Genetics, vol. 17, no. 1, 1009325 . https://doi.org/10.1371/journal.pgen.1009325

In response to physical exercise and diet, skeletal muscle adapts to energetic demands through large transcriptional changes. This remodelling is associated with changes in skeletal muscle DNA methylation which may participate in the metabolic adapta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c37cb40f335d44ea0ef66ae73ff86b0
https://doaj.org/article/b980783ce524444ea61f6aac736af9c6