Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Rhett A, Kovall"'
Autor:
Giulia Diluvio, Tanya T. Kelley, Mohini Lahiry, Annamil Alvarez-Trotta, Ellen M. Kolb, Elena Shersher, Luisana Astudillo, Rhett A. Kovall, Stephan C. Schürer, Anthony J. Capobianco
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 307-320 (2023)
Notch activation complex kinase (NACK) is a component of the Notch transcriptional machinery critical for the Notch-mediated tumorigenesis. However, the mechanism through which NACK regulates Notch-mediated transcription is not well understood. Here,
Externí odkaz:
https://doaj.org/article/b1e16d1d943d4b45b5719482002cf0ad
Autor:
Ellen K Gagliani, Lisa M Gutzwiller, Yi Kuang, Yoshinobu Odaka, Phillipp Hoffmeister, Stefanie Hauff, Aleksandra Turkiewicz, Emily Harding-Theobald, Patrick J Dolph, Tilman Borggrefe, Franz Oswald, Brian Gebelein, Rhett A Kovall
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010335 (2022)
Notch signaling is a conserved pathway that converts extracellular receptor-ligand interactions into changes in gene expression via a single transcription factor (CBF1/RBPJ in mammals; Su(H) in Drosophila). In humans, RBPJ variants have been linked t
Externí odkaz:
https://doaj.org/article/3d3ef8ff2e0245a7bfb1cb014a49f333
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 380 (2023)
Clostridioides difficile, a nosocomial pathogen, is an emerging gut pathobiont causing antibiotic-associated diarrhea. C. difficile infection involves gut colonization and disruption of the gut epithelial barrier, leading to the induction of inflamma
Externí odkaz:
https://doaj.org/article/56d61c87ebfa4198854d9b8464ba97ac
Autor:
Anja Bühler, Bernd M. Gahr, Deung-Dae Park, Alberto Bertozzi, Alena Boos, Mohankrishna Dalvoy, Alexander Pott, Franz Oswald, Rhett A. Kovall, Bernhard Kühn, Gilbert Weidinger, Wolfgang Rottbauer, Steffen Just
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
In contrast to mammals, the zebrafish maintains its cardiomyocyte proliferation capacity throughout adulthood. However, neither the molecular mechanisms that orchestrate the proliferation of cardiomyocytes during developmental heart growth nor in the
Externí odkaz:
https://doaj.org/article/96001da5e7a44875bca991c5371b18cb
Autor:
Yi Kuang, Anna Pyo, Natanel Eafergan, Brittany Cain, Lisa M Gutzwiller, Ofri Axelrod, Ellen K Gagliani, Matthew T Weirauch, Raphael Kopan, Rhett A Kovall, David Sprinzak, Brian Gebelein
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009039 (2021)
Notch signaling controls many developmental processes by regulating gene expression. Notch-dependent enhancers recruit activation complexes consisting of the Notch intracellular domain, the Cbf/Su(H)/Lag1 (CSL) transcription factor (TF), and the Mast
Externí odkaz:
https://doaj.org/article/46e826c091ea4d9db920f08826b85963
Autor:
Daniel J. Hassett, Rhett A. Kovall, Michael J. Schurr, Nalinikanth Kotagiri, Harshita Kumari, Latha Satish
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The life-threatening pandemic concerning multi-drug resistant (MDR) bacteria is an evolving problem involving increased hospitalizations, billions of dollars in medical costs and a remarkably high number of deaths. Bacterial pathogens have demonstrat
Externí odkaz:
https://doaj.org/article/7f645348c22e47f2bb54b46b5a18dd4b
Autor:
Francis M Kobia, Kristina Preusse, Quanhui Dai, Nicholas Weaver, Matthew R Hass, Praneet Chaturvedi, Sarah J Stein, Warren S Pear, Zhenyu Yuan, Rhett A Kovall, Yi Kuang, Natanel Eafergen, David Sprinzak, Brian Gebelein, Eric W Brunskill, Raphael Kopan
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for
Externí odkaz:
https://doaj.org/article/56bb8176d92c404f8da9d4b31d6102f3
Autor:
Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak, Brian Gebelein
Publikováno v:
eLife, Vol 9 (2020)
Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found that inserting
Externí odkaz:
https://doaj.org/article/d503de51d4de46d4b3e298e0644a7d3d
Autor:
Brittany Cain, Jordan Webb, Zhenyu Yuan, David Cheung, Hee-Woong Lim, Rhett A Kovall, Matthew T Weirauch, Brian Gebelein
Publikováno v:
Nucleic Acids Research.
Homeodomain proteins constitute one of the largest families of metazoan transcription factors. Genetic studies have demonstrated that homeodomain proteins regulate many developmental processes. Yet, biochemical data reveal that most bind highly simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce82d39bfe0c5b9355c6900f8921d8a
https://doi.org/10.1093/nar/gkad318
https://doi.org/10.1093/nar/gkad318
Autor:
Zhenyu Yuan, Heiko Praxenthaler, Nassif Tabaja, Rubben Torella, Anette Preiss, Dieter Maier, Rhett A Kovall
Publikováno v:
PLoS Biology, Vol 14, Iss 7, p e1002509 (2016)
Notch is a conserved signaling pathway that specifies cell fates in metazoans. Receptor-ligand interactions induce changes in gene expression, which is regulated by the transcription factor CBF1/Su(H)/Lag-1 (CSL). CSL interacts with coregulators to r
Externí odkaz:
https://doaj.org/article/6d4b97dd248d4e17887d370eb00fe4aa