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Akademický článek

Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Autor: Terunao Takahara, Yuna Amemiya, Risa Sugiyama, Masatoshi Maki, Hideki Shibata

Publikováno v: Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-16 (2020)

Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy. The activity of mTORC1 is dynamically r

Externí odkaz: https://doaj.org/article/3cd1d0a840ca40cbaef928ad37f3d333

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Akademický článek

Amino Acid-Mediated Intracellular Ca2+ Rise Modulates mTORC1 by Regulating the TSC2-Rheb Axis through Ca2+/Calmodulin

Autor: Yuna Amemiya, Nao Nakamura, Nao Ikeda, Risa Sugiyama, Chiaki Ishii, Masatoshi Maki, Hideki Shibata, Terunao Takahara

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13, p 6897 (2021)

Mechanistic target of rapamycin complex 1 (mTORC1) is a master growth regulator by controlling protein synthesis and autophagy in response to environmental cues. Amino acids, especially leucine and arginine, are known to be important activators of mT

Externí odkaz: https://doaj.org/article/e21d571a140e4fdfaa4fa7a5ae4efc25

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Akademický článek

Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons

Autor: Hendrik Schöneborn, Fabian Raudzus, Mathieu Coppey, Sebastian Neumann, Rolf Heumann

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 12, p 4052 (2018)

Cellular activation of RAS GTPases into the GTP-binding “ON„ state is a key switch for regulating brain functions. Molecular protein structural elements of rat sarcoma (RAS) and RAS homolog protein enriched in brain (RHEB) GTPases involved in thi

Externí odkaz: https://doaj.org/article/770bd30c99ae4d1596ed6730d571264a

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Amino Acid-Mediated Intracellular Ca2+ Rise Modulates mTORC1 by Regulating the TSC2-Rheb Axis through Ca2+/Calmodulin

Autor: Nao Nakamura, Nao Ikeda, Hideki Shibata, Yuna Amemiya, Chiaki Ishii, Risa Sugiyama, Masatoshi Maki, Terunao Takahara

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6897, p 6897 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00045ab5a785c582e342ff4f7c2d50de
https://www.mdpi.com/1422-0067/22/13/6897

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Akademický článek

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Akademický článek

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Recent progress in the study of the Rheb family GTPases

Autor: S. Zahra Bathaie, Valerie Fong, Jeffrey J. Heard, Fuyuhiko Tamanoi

Publikováno v: Cellular signalling, vol 26, iss 9

In this review we highlight recent progress in the study of Rheb family GTPases. Structural studies using X-ray crystallography and NMR have given us insight into unique features of this GTPase. Combined with mutagenesis studies, these works have exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e2a120276603a968a6f4cbaddc1a59
https://escholarship.org/uc/item/0jc3g2h4