A saturation hypothesis to explain both enhanced and impaired learning with enhanced plasticity

Autor: TD Barbara Nguyen-Vu, Grace Q Zhao, Subhaneil Lahiri, Rhea R Kimpo, Hanmi Lee, Surya Ganguli, Carla J Shatz, Jennifer L Raymond

Publikováno v: eLife, Vol 6 (2017)

Across many studies, animals with enhanced synaptic plasticity exhibit either enhanced or impaired learning, raising a conceptual puzzle: how enhanced plasticity can yield opposite learning outcomes? Here, we show that the recent history of experienc

Externí odkaz: https://doaj.org/article/0e2fd4986302466e8fec0a76349b0c39

Classroom sound can be used to classify teaching practices in college science courses

Autor: Steven B. Waters, Rachel Small, Amy S. Edwards, Wilfred F. Denetclaw, Segal M. Boaz, Yee-Hung M Chan, Sara K. Krause, Jeffrey N. Schinske, Gloriana Trujillo, Loretta A Kelley, Diana W. Wright, Susan F. Akana, Lance Lund, Mike Wong, Greg S. Spicer, Kristine M. Okimura, Pleuni S. Pennings, Natalia Caporale, Paul Z. Hankamp, Zahur-Saleh Subedar, L. Jeanette Green, Dana T. Byrd, Linda J. McPheron, Kathleen E. Duncan, Holly E Harris, Karen D. Crow, Joseph R. Perez, J R Blair, Stephen B Ingalls, Shannon B. Seidel, Katharyn E. Boyer, Bryan K. Clarkson, Amy Chovnick, Joseph J. Gorga, Peter Ingmire, Diana S Chu, Lori E. Krueger, Terrye L Light, Paul H. Nagami, Brinda Govindan, Lisa M. Schultheis, Andrea Swei, Lily Chen, Robert Patterson, Jonathan D. Knight, Scott William Roy, Joseph M Romeo, Shangheng Sit, Jonathon H. Stillman, Leticia Márquez-Magaña, Sara E. Cooper, Colin D Harrison, Hilary P Benton, Gloria Nusse, Mark Kamakea, J. Rebecca Jacobs, Sally G. Pasion, Carmen R. Domingo, Laura W. Burrus, Rhea R. Kimpo, Zheng-Hui He, Kimberly D. Tanner, Vanessa C Miller-Sims, José R. de la Torre, Susanne Lietz, Jennifer M. Wade, Travis E. Bejines, Tatiane Russo-Tait, Gigi N. Acker, Julia K. Willsie, Steven L. Weinstein, Christopher A. Moffatt, Melinda T. Owens, Lakshmikanta Sengupta, Brad Balukjian, Karen L. Erickson, Jason B. Bram, Edward J. Carpenter, Megumi Fuse, Briana K. McCarthy, Pamela C. Muick, Blake Riggs, Catherine Creech

Active-learning pedagogies have been repeatedly demonstrated to produce superior learning gains with large effect sizes compared with lecture-based pedagogies. Shifting large numbers of college science, technology, engineering, and mathematics (STEM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2706094a54ecd23a959d42dab1423068
https://europepmc.org/articles/PMC5373389/

Author response: A saturation hypothesis to explain both enhanced and impaired learning with enhanced plasticity

Autor: Carla J. Shatz, TD Barbara Nguyen-Vu, Grace Zhao, Surya Ganguli, Subhaneil Lahiri, Rhea R. Kimpo, Jennifer L. Raymond, Hanmi Lee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df1fba4f4efcf88ed47131adf67af02b
https://doi.org/10.7554/elife.20147.028

Impaired Motor Learning in the Vestibulo-Ocular Reflex in Mice with Multiple Climbing Fiber Input to Cerebellar Purkinje Cells

Autor: Jennifer L. Raymond, Rhea R. Kimpo

Publikováno v: The Journal of Neuroscience. 27:5672-5682

A unique feature of the cerebellar architecture is that Purkinje cells in the cerebellar cortex each receive input from a single climbing fiber. In mice deficient in the γ isoform of protein kinase C (PKCγ−/−mice), this normal architecture is d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d01caf0f10112cd0291961c193bc9c0
https://doi.org/10.1523/jneurosci.0801-07.2007

Distinct Patterns of Stimulus Generalization of Increases and Decreases in VOR Gain

Autor: Rhea R. Kimpo, Jennifer L. Raymond, Michael C. Ke, Akira Katoh, Edward S. Boyden

Publikováno v: Journal of Neurophysiology. 94:3092-3100

Motor learning must be capable of increasing or decreasing the amplitude of movements to meet the demands of the environment. One way to implement such opposite learned changes would be to store them with bidirectional plasticity mechanisms (i.e., lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d3e3c7a2329d15c660182918ba826b
https://doi.org/10.1152/jn.00048.2005