Zika virus capsid protein closed structure modulates binding to host lipid systems.

Autor: Martins AS; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Carvalho FA; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Nascimento AR; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Silva NM; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Rebelo TV; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Faustino AF; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Enguita FJ; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Huber RG; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Santos NC; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Martins IC; Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2024 Sep; Vol. 33 (9), pp. e5142.

Membrane platform protein PulF of the Klebsiella type II secretion system forms a trimeric ion channel essential for endopilus assembly and protein secretion.

Autor: Guilvout I; Institut Pasteur, Université Paris Cité, CNRS UMR 3528, Biochemistry of Macromolecular Interactions Unit, Paris, France., Samsudin F; Bioinformatics Institute (A-STAR), Singapore, Singapore., Huber RG; Bioinformatics Institute (A-STAR), Singapore, Singapore., Bond PJ; Bioinformatics Institute (A-STAR), Singapore, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, Singapore., Bardiaux B; Institut Pasteur, Université Paris Cité, CNRS UMR 3528, Structural Bioinformatics Unit, Paris, France.; Institut Pasteur, Université Paris Cité, CNRS UMR 3528, Bacterial Transmembrane Systems Unit, Paris, France., Francetic O; Institut Pasteur, Université Paris Cité, CNRS UMR 3528, Biochemistry of Macromolecular Interactions Unit, Paris, France.

Publikováno v: MBio [mBio] 2024 Jan 16; Vol. 15 (1), pp. e0142323. Date of Electronic Publication: 2023 Dec 08.

Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes.

Autor: Chin WX; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore., Kong HY; NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Zhu IXY; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore., Teo ZY; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore., Faruk R; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore., Lee RCH; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore., Ho SX; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore., Aw ZQ; NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Yi B; NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Hou XJ; Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore., Tan AKY; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore., Yogarajah T; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore., Huber RG; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore., Cai Y; Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore., Wan Y; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore., Chu JJH; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore.; NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.

Publikováno v: PLoS pathogens [PLoS Pathog] 2023 Oct 26; Vol. 19 (10), pp. e1011753. Date of Electronic Publication: 2023 Oct 26 (Print Publication: 2023).

Tracking and blocking interdependencies of cellular BRAF-MEK oncokinase activities.

Autor: Fleischmann J; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, Innsbruck 6020, Austria., Schwaighofer S; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, Innsbruck 6020, Austria.; Tyrolean Cancer Research Institute (TKFI), Innrain 66, Innsbruck 6020, Austria., De Falco L; Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Singapore., Enzler F; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, Innsbruck 6020, Austria., Feichtner A; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, Innsbruck 6020, Austria., Kugler V; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, Innsbruck 6020, Austria., Tschaikner P; Tyrolean Cancer Research Institute (TKFI), Innrain 66, Innsbruck 6020, Austria.; Institute of Molecular Biology, University of Innsbruck, Technikerstrasse 25, Innsbruck 6020, Austria., Huber RG; Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Singapore., Stefan E; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, Innsbruck 6020, Austria.; Tyrolean Cancer Research Institute (TKFI), Innrain 66, Innsbruck 6020, Austria.; Institute of Molecular Biology, University of Innsbruck, Technikerstrasse 25, Innsbruck 6020, Austria.

Publikováno v: PNAS nexus [PNAS Nexus] 2023 Jun 05; Vol. 2 (6), pp. pgad185. Date of Electronic Publication: 2023 Jun 05 (Print Publication: 2023).

Identification of potential pathways and biomarkers linked to progression in ALS.

Autor: Huber RG; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Matrix #07-01, 30 Biopolis Street, Singapore, 138671, Singapore., Pandey S; Department of Neurology, McKnight Brain Institute, and Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, 32611, USA., Chhangani D; Department of Neurology, McKnight Brain Institute, and Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, 32611, USA., Rincon-Limas DE; Department of Neurology, McKnight Brain Institute, and Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, 32611, USA., Staff NP; Department of Neurology, Mayo Clinic, Rochester, Minnesota, 55905, USA., Yeo CJJ; Agency for Science, Technology and Research (A*STAR), IMCB, 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore.; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA.; Lee Kong Chian School of Medicine, Imperial College London and NTU Singapore, Singapore, 308232, Singapore.; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, AB243FX, Scotland, UK.; National Neuroscience Institute, TTSH Campus, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.; Duke NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

Publikováno v: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2023 Feb; Vol. 10 (2), pp. 150-165. Date of Electronic Publication: 2022 Dec 19.