Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

Autor: Robin M. Delaine-Smith, Eleni Maniati, Beatrice Malacrida, Sam Nichols, Reza Roozitalab, Roanne R. Jones, Laura S.M. Lecker, Oliver M.T. Pearce, Martin M. Knight, Frances R. Balkwill

Publikováno v: iScience, Vol 24, Iss 6, Pp 102674- (2021)

Summary: In a multi-level “deconstruction” of omental metastases, we previously identified a prognostic matrisome gene expression signature in high-grade serous ovarian cancer (HGSOC) and twelve other malignancies. Here, our aim was to understand

Externí odkaz: https://doaj.org/article/6068ad32821044adbec1edf7e797e977

Tumour microenvironment 3D-modelling: simplicity to complexity and back again

Autor: Reza Roozitalab, Richard Grose, Edward P. Carter, Shayin V. Gibson

Publikováno v: Carter, E P, Roozitalab, R, Gibson, S V & Grose, R P 2021, ' Tumour microenvironment 3D-modelling : simplicity to complexity and back again ', Trends in cancer, vol. 7, no. 11, pp. 1033-1046 . https://doi.org/10.1016/j.trecan.2021.06.009

Tumours are surrounded by a host of noncancerous cells that fulfil both supportive and suppressive roles within the tumour microenvironment (TME). The drive to understand the biology behind each of these components has led to a rapid expansion in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50d602c58494a5c533a531dbaacbb3d
https://doi.org/10.1016/j.trecan.2021.06.009

An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues

Autor: Nancy T Li, Nila C Wu, Ruonan Cao, Jose L Cadavid, Simon Latour, Xiaoya Lu, Yutong Zhu, Mirjana Mijalkovic, Reza Roozitalab, Alison P McGuigan

Complex 3D bioengineered tumour models provide the opportunity to better capture the heterogeneity of patient tumours. Patient-derived organoids are emerging as a useful tool to study tumour heterogeneity and variation in patient responses. Organoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::124424b184a081db7e6e7b5988ff503b
https://doi.org/10.1101/2022.08.14.503643

Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

Autor: Reza Roozitalab, Roanne R. Jones, Oliver M. T. Pearce, Beatrice Malacrida, Sam Nichols, Laura S.M. Lecker, Frances R. Balkwill, Robin M. Delaine-Smith, Eleni Maniati, Martin M. Knight

Publikováno v: iScience, Vol 24, Iss 6, Pp 102674-(2021)
iScience

Summary In a multi-level “deconstruction” of omental metastases, we previously identified a prognostic matrisome gene expression signature in high-grade serous ovarian cancer (HGSOC) and twelve other malignancies. Here, our aim was to understand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077fcbd9aa2de37df67d3c0c5ef5772f
https://doi.org/10.1101/2021.02.01.428374