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Akademický článek

Spotlight on dinutuximab in the treatment of high-risk neuroblastoma: development and place in therapy

Autor: Keyel ME, Reynolds CP

Publikováno v: Biologics: Targets & Therapy, Vol Volume 13, Pp 1-12 (2018)

Michelle E Keyel,1,2 C Patrick Reynolds1–4 1Cancer Center, 2Department of Pediatrics, 3Department of Internal Medicine, 4Department of Cell Biology & Biochemistry, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA A

Externí odkaz: https://doaj.org/article/54f44a9d7f4444ea894f7bcee0cad1d9

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ALT Neuroblastoma Chemoresistance due to ATM Activation by Telomere Dysfunction is Reversible with the ATM Inhibitor AZD0156

Autor: Wan Hsi Chen, Monish Ram Makena, Aaron Smith, Venkatesh Pilla Reddy, Reynolds Cp, Eslinger C, Balakrishna Koneru, Burrow Ta, Joanne Wilson, Steve T. Durant, Elaine Cadogan, Ashly Hindle, Thinh H. Nguyen, Ahsan Farooqi

Cancers overcome replicative immortality by activating either telomerase or an alternative lengthening of telomeres (ALT) mechanism. ALT occurs in ∼ 25% of high-risk neuroblastomas and relapse or progression in ALT neuroblastoma patients during or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24a34a0a253bc93140e72349257e5963
https://doi.org/10.1101/2021.04.06.438692

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Probable fatal drug interaction between intravenous fenretinide, ceftriaxone, and acetaminophen: A case report from a New Approaches to Neuroblastoma (NANT) Phase i study

Autor: Matthay, Katherine, Kang, MH, Villablanca, JG, Glade, JL, Matthay, KK, Groshen, S, Sposto, R, Czarnecki, S, Ames, MM, Reynolds, CP, Marachelian, A

Publikováno v: Matthay, Katherine; Kang, MH; Villablanca, JG; Glade, JL; Matthay, KK; Groshen, S; et al.(2014). Probable fatal drug interaction between intravenous fenretinide, ceftriaxone, and acetaminophen: A case report from a New Approaches to Neuroblastoma (NANT) Phase i study. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0jx2f57w

Background: Patients with relapsed/refractory stage 4 high-risk neuroblastoma were enrolled on a phase I study (NANT2004-03) of intravenous fenretinide emulsion. Pharmacokinetic samples were collected during and after the infusion, and the levels wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8f9754407f2cd0f94f7f034418d9ba8d
http://www.escholarship.org/uc/item/0jx2f57w

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Fine-needle aspiration cytology and the diagnosis of neoplasms in the pediatric age group

Autor: Ben J. Glasgow, Reynolds Cp, Nora Ostrzega, Lester J. Layfield

Publikováno v: Diagnostic Cytopathology. 7:451-461

Sixty-six aspirates obtained from 63 pediatric patients clinically suspected of having small cell malignancies were studied by a variety of techniques to determine the accuracy and utility of fine-needle aspiration (FNA) in the diagnosis of small rou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f30bf2628cdc4565db5585f549a2add
https://doi.org/10.1002/dc.2840070504

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DIMSCAN: A Microcomputer Fluorescence-Based Cytotoxicity Assay for Preclinical Testing of Combination Chemotherapy

Autor: Reynolds Cp, Nino Keshelava, Krejsa J, Frgala T, Kalous O

DIMSCAN is a semiautomatic fluorescence-based digital image microscopy system that quantifies relative total (using a DNA stain) or viable (using fluorescein diacetate [FDA]) cell numbers in tissue culture multiwell plates ranging from 6 to 384 wells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1ee3217a1b8ff81e3013c58fb622f41
https://doi.org/10.1385/1-59259-869-2:139

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N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes

Autor: Peter H. O'Donnell, Reynolds Cp, Guo Wx, Barry J. Maurer

Publikováno v: Leukemia. 16(5)

The retinoid, N-(4-hydroxyphenyl)retinamide (4-HPR), mediates p53-independent cytotoxicity and can increase reactive oxygen species and ceramide in solid tumor cell lines. We determined changes in ceramide and cytotoxicity upon treatment with 4-HPR (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691187cc3d18ab4f766cdcf2bac6c927
https://pubmed.ncbi.nlm.nih.gov/11986953

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Differentiating agents in pediatric malignancies: retinoids in neuroblastoma

Autor: Reynolds Cp

Publikováno v: Current oncology reports. 2(6)

Retinoids are derivatives of vitamin A that include all- trans-retinoic acid (ATRA), 13-cis-retinoic acid, (13-cis-RA), and fenretinide (4-HPR). High levels of either ATRA or 13-cis-RA can cause arrest of cell growth and morphologic differentiation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adf28d251e952d3e34a68369ce33003
https://pubmed.ncbi.nlm.nih.gov/11122886

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