Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models

Autor: Zakharenko, A.L., Luzina, O.A., Sokolov, D.N., Kaledin, V.I., Nikolin, V.P., Popova, N.A., Patel, J., Zakharova, O.D., Chepanova, A.A., Zafar, A., Reynisson, J., Leung, E., Leung, I.K.H., Volcho, K.P., Salakhutdinov, N.F., Lavrik, O.I.

Publikováno v: In European Journal of Medicinal Chemistry 1 January 2019 161:581-593

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.

Autor: Kelly G; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Kataura T; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK; Department of Neurology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan., Panek J; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Ma G; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Salmonowicz H; ReMedy International Research Agenda Unit, IMol Polish Academy of Sciences, Warsaw 02-247, Poland., Davis A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Kendall H; Wellcome Centre for Mitochondrial Research, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Brookes C; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Ayine-Tora DM; Department of Chemistry, University of Ghana, LG 56, Legon-Accra, Ghana., Banks P; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Nelson G; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Dobby L; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Pitrez PR; FMUC - Faculty of Medicine, Pólo das Ciências da Saúde, Unidade Central Azinhaga de Santa Comba, Coimbra 3000-354, Portugal., Booth L; Translation and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Costello L; Department of Biosciences, Durham University, Durham DH1 3LE, UK., Richardson GD; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Lovat P; Precision Medicine, Translation and Clinical Research Institute, Newcastle University Centre for Cancer, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Przyborski S; Department of Biosciences, Durham University, Durham DH1 3LE, UK., Ferreira L; FMUC - Faculty of Medicine, Pólo das Ciências da Saúde, Unidade Central Azinhaga de Santa Comba, Coimbra 3000-354, Portugal., Greaves L; Wellcome Centre for Mitochondrial Research, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Szczepanowska K; ReMedy International Research Agenda Unit, IMol Polish Academy of Sciences, Warsaw 02-247, Poland., von Zglinicki T; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Miwa S; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK., Brown M; The Procter & Gamble Company, Cincinnati, OH 45040, USA., Flagler M; The Procter & Gamble Company, Cincinnati, OH 45040, USA., Oblong JE; The Procter & Gamble Company, Cincinnati, OH 45040, USA., Bascom CC; The Procter & Gamble Company, Cincinnati, OH 45040, USA., Carroll B; School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK., Reynisson J; School of Pharmacy and Bioengineering, Keele University, Newcastle under Lyme ST5 5BG, UK., Korolchuk VI; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK. Electronic address: viktor.korolchuk@newcastle.ac.uk.

Publikováno v: Developmental cell [Dev Cell] 2024 Aug 05; Vol. 59 (15), pp. 1924-1939.e7. Date of Electronic Publication: 2024 Jun 18.

Correction: Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors.

Autor: Dolan JP; Lennard-Jones Laboratory, School of Chemical & Physical Sciences, Keele University Keele Staffordshire ST5 5BG UK g.j.miller@keele.ac.uk.; Centre for Glycoscience, Keele University Keele Staffordshire ST5 5BG UK., Ahmadipour S; Department of Chemistry & Manchester Institute of Biotechnology, The University of Manchester 131 Princess Street Manchester M1 7DN UK., Wahart AJC; Lennard-Jones Laboratory, School of Chemical & Physical Sciences, Keele University Keele Staffordshire ST5 5BG UK g.j.miller@keele.ac.uk.; Centre for Glycoscience, Keele University Keele Staffordshire ST5 5BG UK., Cheallaigh AN; Lennard-Jones Laboratory, School of Chemical & Physical Sciences, Keele University Keele Staffordshire ST5 5BG UK g.j.miller@keele.ac.uk.; Centre for Glycoscience, Keele University Keele Staffordshire ST5 5BG UK., Sari S; Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry 06100 Ankara Turkey., Eurtivong C; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University 447 Si Ayutthaya Road, Ratchathewi Bangkok 10400 Thailand., Lima MA; Centre for Glycoscience, Keele University Keele Staffordshire ST5 5BG UK.; School of Life Sciences, Keele University Keele Staffordshire ST5 5BG UK., Skidmore MA; Centre for Glycoscience, Keele University Keele Staffordshire ST5 5BG UK.; School of Life Sciences, Keele University Keele Staffordshire ST5 5BG UK., Volcho KP; N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences 630090 Novosibirsk Russia., Reynisson J; Centre for Glycoscience, Keele University Keele Staffordshire ST5 5BG UK.; Hornbeam Building, School of Pharmacy & Bioengineering, Keele University Keele Staffordshire ST5 5BG UK., Field RA; Department of Chemistry & Manchester Institute of Biotechnology, The University of Manchester 131 Princess Street Manchester M1 7DN UK., Miller GJ; Lennard-Jones Laboratory, School of Chemical & Physical Sciences, Keele University Keele Staffordshire ST5 5BG UK g.j.miller@keele.ac.uk.; Centre for Glycoscience, Keele University Keele Staffordshire ST5 5BG UK.

Publikováno v: RSC chemical biology [RSC Chem Biol] 2024 Jul 08; Vol. 5 (8), pp. 800-801. Date of Electronic Publication: 2024 Jul 08 (Print Publication: 2024).

Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters.

Autor: Milunovic MNM; Institute of Inorganic Chemistry, University of Vienna, Vienna A-1090, Austria., Ohui K; Institute of Inorganic Chemistry, University of Vienna, Vienna A-1090, Austria., Besleaga I; Institute of Inorganic Chemistry, University of Vienna, Vienna A-1090, Austria., Petrasheuskaya TV; Department of Molecular and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7-8, Szeged H-6720, Hungary.; MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged H-6720, Hungary., Dömötör O; Department of Molecular and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7-8, Szeged H-6720, Hungary.; MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged H-6720, Hungary., Enyedy ÉA; Department of Molecular and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7-8, Szeged H-6720, Hungary.; MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged H-6720, Hungary., Darvasiova D; Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava SK-81237, Slovakia., Rapta P; Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava SK-81237, Slovakia., Barbieriková Z; Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava SK-81237, Slovakia., Vegh D; Institute of Organic Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava SK-81237, Slovakia., Tóth S; Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Hungarian Research Network, Magyar Tudósok körútja 2, Budapest H-1117, Hungary., Tóth J; Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Hungarian Research Network, Magyar Tudósok körútja 2, Budapest H-1117, Hungary., Kucsma N; Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Hungarian Research Network, Magyar Tudósok körútja 2, Budapest H-1117, Hungary., Szakács G; Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Hungarian Research Network, Magyar Tudósok körútja 2, Budapest H-1117, Hungary.; Center for Cancer Research, Medical University of Vienna, Vienna A-1090, Austria., Popović-Bijelić A; Faculty of Physical Chemistry, University of Belgrade, Belgrade 11158, Serbia., Zafar A; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand., Reynisson J; School of Pharmacy and Bioengineering, Keele University, Newcastle-under-Lyme, Staffordshire ST5 5BG, United Kingdom., Shutalev AD; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russian Federation., Bai R; Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Diagnosis and Treatment, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, United States., Hamel E; Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Diagnosis and Treatment, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, United States., Arion VB; Institute of Inorganic Chemistry, University of Vienna, Vienna A-1090, Austria.; Inorganic Polymers Department, 'Petru Poni' Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, Iasi 700487, Romania.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jun 13; Vol. 67 (11), pp. 9069-9090. Date of Electronic Publication: 2024 May 21.

A predictive multi-linear regression model for organic micropollutants, based on a laboratory-scale column study simulating the river bank filtration process

Autor: Bertelkamp, C., Verliefde, A.R.D., Reynisson, J., Singhal, N., Cabo, A.J., de Jonge, M., van der Hoek, J.P.

Publikováno v: In Journal of Hazardous Materials 5 March 2016 304:502-511