Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Reynalda Dejesus"'
Autor:
Xin Gu, Brande Thomas-Fowlkes, Dorothy Levorse, Harry R. Chobanian, Timothy Cutarelli, Alexander Pasternak, Adam B. Weinglass, Ian W. Davies, Martin Koehler, Michael Margulis, Fa-Xiang Ding, Joel B. Yudkovitz, Jinlong Jiang, Haifeng Tang, Lee-Yuh Pai, Barbara Pio, Shuzhi Dong, Mengwei Hu, Kathleen A. Sullivan, Jack Gibson, Thomas Bateman, Koppara Samuel, Xiaoyan Zhou, Caryn Hampton, Reynalda deJesus, Kevin Houle, Emma R. Parmee
Publikováno v:
Journal of medicinal chemistry. 64(11)
A renal outer medullary potassium channel (ROMK, Kir1.1) is a putative drug target for a novel class of diuretics with potential for treating hypertension and heart failure. Our first disclosed clinical ROMK compound, 2 (MK-7145), demonstrated robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c25db7e0321a07221c83e7a37add1c
https://pubmed.ncbi.nlm.nih.gov/34038119
https://pubmed.ncbi.nlm.nih.gov/34038119
Autor:
Terry Roemer, James R. Tata, Charles G. Garlisi, Mihirbaran Mandal, Christina B. Madsen-Duggan, Ginny D. Ho, Todd Mayhood, Jin Wu, Marc A. Labroli, John P. Caldwell, Alexei V. Buevich, Emma R. Parmee, Hao Wang, Jing Su, Paul Tawa, Sandra Koseoglu, Xiujuan Wen, Sang Ho Lee, Kallol Basu, Payal R. Sheth, Shu-Wei Yang, David G. McLaren, Haifeng Tang, Zheng Tan, Reynalda deJesus, Jenny Liu, Erika Walsh, Sookhee Ha, Christopher M. Tan, Li Xiao, Diane Rindgen, Amy M. Flattery, Debra Mcguinness, Christine Yang, Charles Gill, Paul L. Walsh, Lianzhu Liang
Publikováno v:
Journal of Medicinal Chemistry. 60:3851-3865
We describe our optimization efforts to improve the physicochemical properties, solubility, and off-target profile of 1, an inhibitor of TarO, an early stage enzyme in the biosynthetic pathway for wall teichoic acid (WTA) synthesis. Compound 1 displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751e1e6ee34ab10f04e560b0ced7bc22
https://doi.org/10.1021/acs.jmedchem.7b00113
https://doi.org/10.1021/acs.jmedchem.7b00113
Autor:
Olga Berejnaia, Hao Wang, Christine Yang, Marc A. Labroli, David G. McLaren, Michael Kavana, Jing Su, Reynalda deJesus, Payal R. Sheth, David Hesk, Jianying Xiao, Christopher M. Tan, Charles Gill
Publikováno v:
Analytical Biochemistry. 518:9-15
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has created an urgent need for new therapeutic agents capable of combating this threat. We have previously reported on the discovery of novel inhibitors targeting enzymes involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a32ed93466423759a5eafd65479aba4
https://doi.org/10.1016/j.ab.2016.10.027
https://doi.org/10.1016/j.ab.2016.10.027
Autor:
Alexander Pasternak, Paul Mazur, Michael R. Tota, Stephen D. Goble, Lihu Yang, Donna L. Hreniuk, Andrew D. Howard, Reynalda deJesus, Sander G. Mills, Christine C. Chung, Scott D. Feighner
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(21)
This Letter describes optimization of ghrelin receptor antagonists and inverse agonists starting from a screening hit.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfcd1b4cde935121608bb1f09ea58b2
https://pubmed.ncbi.nlm.nih.gov/19767208
https://pubmed.ncbi.nlm.nih.gov/19767208
Autor:
David Louis Feldman, Randy L. Webb, Warren Lee, Ashok Hospattankar, Michael Jeune, Alan D. Neubert, Natalie A. Bilci, Natalya Alexander, Andrew M. Yuan, Therese C Mogelesky, Aida E. Navarrete, Gary Michael Ksander, Joyce C. Gibson, Eric Carlson, Haamid M. Sharif, Eli M. Wallace, Jong Wasvery, Reynalda Dejesus, Paivi Jaana Kukkola, Edna Cahill, Michael A. Moskal, Cynthia A. Fink, Steele Ronald Edward, Zouhair F. Stephan, Kevin Poirier
Publikováno v:
Journal of medicinal chemistry. 44(26)
The synthesis and biological activities of biarylamide-substituted diaminoindanes as microsomal triglyceride transfer protein (MTP) inhibitors are described. One of the more potent compounds, 8aR, inhibited both the secretion of apoB from Hep G2 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0586d5545b1198cefd0a15bfddbac44
https://pubmed.ncbi.nlm.nih.gov/11741485
https://pubmed.ncbi.nlm.nih.gov/11741485
Autor:
Carol Berry, Yumi Sakane, Angelo J. Trapani, Clive G. Diefenbacher, Andrew M. Yuan, Gary Michael Ksander, Raj D. Ghai, Reynalda deJesus
Publikováno v:
Journal of medicinal chemistry. 38(10)
The synthesis of three series of dicarboxylic acid dipeptide neutral endopeptidase 24.11 (NEP) inhibitors is described. In particular, the amino butyramide 21a exhibited potent NEP inhibitory activity (IC50 = 5.0 nM) in vitro and in vivo. Blood level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfde49b64635626fda420705aa8ab574
https://pubmed.ncbi.nlm.nih.gov/7752193
https://pubmed.ncbi.nlm.nih.gov/7752193
Publikováno v:
Canadian Journal of Physiology & Pharmacology. May2002, Vol. 80 Issue 5, pi. 4p.
Autor:
Ksander, Gary M., Shetty, Suraj S., DelGrande, Dominick, Balwierczak, Joseph L., Bruseo, Charles W., Savage, Paula, deJesus, Reynalda, Yuan, Andrew, Webb, Randy L., Jeng, Arco Y.
Publikováno v:
Canadian Journal of Physiology & Pharmacology. May2002, Vol. 80 Issue 5, p464. 6p.
Publikováno v:
Canadian Journal of Physiology & Pharmacology. Apr2002, Vol. 80 Issue 4, pi. 4p.