Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Reynald, Hocquemiller"'
Autor:
Christophe Gleye, Christian Bories, Pierre Champy, Philippe M. Loiseau, T. A. Okpekon, S Yolou, Reynald Hocquemiller, M Millot, Alain Laurens
Publikováno v:
Natural Product Research. 23:909-915
Bioactivity-guided fractionations of chloromethylenic extract of the roots of U. afzelii (Annonaceae), using Leishmania donovani and Trypanosoma brucei brucei bioassay, resulted in the isolation of the two known compounds, emorydone (1) and demethoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58ba324c2a574f3b4c4f6b6dc6b90b4
https://doi.org/10.1080/14786410802497240
https://doi.org/10.1080/14786410802497240
Autor:
Santos A. Susin, Séverine Derbré, Myriam Taverna, Céline Boursier, Reynald Hocquemiller, Joëlle Vinh, Erwan Poupon, Sophie Gil, Valérie Nicolas, Emmanuelle Demey-Thomas
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2008, epub ahead of print. ⟨10.1016/j.bmcl.2008.09.091⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2008, epub ahead of print. ⟨10.1016/j.bmcl.2008.09.091⟩
Bioorganic and Medicinal Chemistry Letters, 2008, epub ahead of print. ⟨10.1016/j.bmcl.2008.09.091⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2008, epub ahead of print. ⟨10.1016/j.bmcl.2008.09.091⟩
International audience; Acetogenins of the Annonaceae are strong inhibitors of mitochondrial complex I but discrepancies in the structure/activity relationships pled the search for other targets within the whole cell proteome. Combining hemisynthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa50830ea69b74eb141346752a4b450e
https://doi.org/10.1016/j.bmcl.2008.09.091
https://doi.org/10.1016/j.bmcl.2008.09.091
Autor:
Christian Bories, Julie Desrivot, Reynald Hocquemiller, Philippe M. Loiseau, Bruno Figadère, Christine Herrenknecht, Alain Fournet, Najla Garbi, Eric Prina, Gilles Ponchel
Publikováno v:
Biomedicine & Pharmacotherapy. 61:441-450
Quinolines substituted on their carbon 2 have in vivo antileishmanial activity but some of them could not be detected in plasma when assayed for pharmacokinetic studies, suggesting a sequestration of the drugs by components of the blood compartment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31847ef6c33c53b3a941d6fbc8f13214
https://doi.org/10.1016/j.biopha.2007.03.004
https://doi.org/10.1016/j.biopha.2007.03.004
Publikováno v:
Natural Product Research. 21:698-703
The aerial parts of Boronia ternata var. elongata from western Australia has yielded three new 2-acyl-4(1H)-quinolinone alkaloids, characterised as 2-n-pentyl-4(1H)-quinolinone, 1-methyl-2-n-pentyl-4(1H)-quinolinone and 1-methyl-2-(1 xi-methyl)-propy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef19b26eda73fa2db246e685c8f0e94
https://doi.org/10.1080/14786410600898672
https://doi.org/10.1080/14786410600898672
Publikováno v:
Tetrahedron Letters. 47:5905-5908
Stereoselective synthesis of C13–C29 fragment of caribenolide I, a potent antitumour macrolide isolated from a marine dinoflagellate Amphidinium sp. is described. The key step relies on a highly diastereoselective C-glycosylation, using a bulky chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::889f65e8ec7bc8f628454a4d0af94cc6
https://doi.org/10.1016/j.tetlet.2006.06.060
https://doi.org/10.1016/j.tetlet.2006.06.060
Autor:
Ulrich Brandt, Diego Cortes, Reynald Hocquemiller, Erwan Poupon, Guy Lewin, Vanessa Romero, Eva Peris, Romain Duval
Publikováno v:
Tetrahedron. 62:6248-6257
A small library of squamocin analogues has been prepared and screened biologically (cytotoxicity, inhibition of mitochondrial complex I and complex III). To centre diversity on a crucial part of the molecule (i.e., the α,β-unsaturated lactone), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c0f0afff4d0b324fc29ba6d90ccf38
https://doi.org/10.1016/j.tet.2006.04.066
https://doi.org/10.1016/j.tet.2006.04.066
Publikováno v:
Tetrahedron Letters. 47:4175-4180
Stereoselective synthesis of C1–C11 fragment of caribenolide I, a potent antitumour macrolide isolated from a marine dinoflagellate Amphidinium sp. is described. The key steps rely on asymmetric aldol reactions, to control the absolute configuratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d11790e84480e36e99002f337277f3
https://doi.org/10.1016/j.tetlet.2006.04.071
https://doi.org/10.1016/j.tetlet.2006.04.071
Autor:
Matar Seck, Blandine Séon-Méniel, Jean-Christophe Jullian, Bruno Figadère, Xavier Franck, Reynald Hocquemiller
Publikováno v:
Letters in Organic Chemistry. 3:390-395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29a44f3b93379de3cab6566f2f967224
https://doi.org/10.2174/157017806776611818
https://doi.org/10.2174/157017806776611818
Publikováno v:
Tetrahedron. 62:5248-5253
A single biomimetic cascade sequence featuring intermolecular followed by intramolecular cyclizations allowed the biomimetic synthesis of nitraramine and the formation of an interesting original cage-like structure from simple C5 lysine-derived metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6525ce0e137c6168dd94da76eee7c0a9
https://doi.org/10.1016/j.tet.2005.12.069
https://doi.org/10.1016/j.tet.2005.12.069
Autor:
Xavier Franck, Xu Hui, Bruno Figadère, Philippe M. Loiseau, Reynald Hocquemiller, Julie Desrivot, Christian Bories
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:815-820
A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0327ef491071447ed215ac40259aa4ef
https://doi.org/10.1016/j.bmcl.2005.11.025
https://doi.org/10.1016/j.bmcl.2005.11.025