Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Reymundo Villa"'
Autor:
Manoj K. Kashyap, Deepak Kumar, Reymundo Villa, James J. La Clair, Chris Benner, Roman Sasik, Harrison Jones, Emanuela M. Ghia, Laura Z. Rassenti, Thomas J. Kipps, Michael D. Burkart, Januario E. Castro
Publikováno v:
Haematologica, Vol 100, Iss 7 (2015)
RNA splicing plays a fundamental role in human biology. Its relevance in cancer is rapidly emerging as demonstrated by spliceosome mutations that determine the prognosis of patients with hematologic malignancies. We report studies using FD-895 and pl
Externí odkaz:
https://doaj.org/article/d2cf4769f51e47a1a7c8713f79b75b8c
Autor:
Deepak Kumar, Manoj K. Kashyap, Zhe Yu, Ide Spaanderman, Reymundo Villa, Thomas J. Kipps, James J. La Clair, Michael D. Burkart, Januario E. Castro
Publikováno v:
Aging, vol 14, iss 5
Alterations in RNA splicing are associated with different malignancies, including leukemia, lymphoma, and solid tumors. The RNA splicing modulators such as FD-895 and pladienolide B have been investigated in different malignancies to target/modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3d5daa66056890ebf5ab8e44f764d3
https://escholarship.org/uc/item/94s3229m
https://escholarship.org/uc/item/94s3229m
Autor:
Reymundo Villa, Deepak Kumar, Thomas J. Kipps, Manoj Kumar Kashyap, Januario E. Castro, Zhe Yu, Michael D. Burkart, Ide Spaanderman, James J. La Clair
BackgroundAlterations in RNA splicing are associated with different malignancies including leukemia, lymphoma, and solid tumors. The RNA splicing modulators such as FD-895 and pladienolide B have been investigated in different malignancies to target/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04770653d1cec97e901a6d736b0e52b
https://doi.org/10.21203/rs.3.rs-768225/v1
https://doi.org/10.21203/rs.3.rs-768225/v1
Autor:
Thomas J. Kipps, Manoj Kumar Kashyap, Laura Z. Rassenti, Reymundo Villa, Christopher Benner, Michael D. Burkart, Deepak Kumar, James J. La Clair, Harrison Jones, Emanuela M. Ghia, Roman Sasik, Januario E. Castro
Publikováno v:
Haematologica. 100:945-954
RNA splicing plays a fundamental role in human biology. Its relevance in cancer is rapidly emerging as demonstrated by spliceosome mutations that determine the prognosis of patients with hematologic malignancies. We report studies using FD-895 and pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c734a64c1a49e39e909290729b93fd
https://doi.org/10.3324/haematol.2014.122069
https://doi.org/10.3324/haematol.2014.122069
Autor:
Kenneth R. Carter, J. Campbell Scott, Greg M. Wallraff, Sally Ann Swanson, Jian P. Chen, Weijie Zhang, Luisa D. Bozano, Reymundo Villa, Jesse R. Salem
Publikováno v:
Chemistry of Materials. 15:2305-2312
We have synthesized a series of diphenylamine-substituted coumarin, (dicyanomethylene)pyran, and benzophenoxazone dyes and report on their optical and electroluminescent properties, thermal and photooxidative stabilities, and potential as red and gre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27446f212b3c986666593bf4091f212a
https://doi.org/10.1021/cm021056q
https://doi.org/10.1021/cm021056q
Autor:
Manoj Kumar Kashyap, Michael D. Burkart, Reymundo Villa, Deepak Kumar, Thomas J. Kipps, James J. La Clair, Januario E. Castro
Publikováno v:
Journal of medicinal chemistry. 56(17)
Targeting the spliceosome with small molecule inhibitors provides a new avenue to target cancer by intercepting alternate splicing pathways. Although our understanding of alternate mRNA splicing remains poorly understood, it provides an escape pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ce3f06f6324f16d28f8887d0982115
https://pubmed.ncbi.nlm.nih.gov/23919277
https://pubmed.ncbi.nlm.nih.gov/23919277
Autor:
Eli Chapman, Reymundo Villa, Michael D. Burkart, MinJin Kang, Ioanna Ntai, Neil L. Kelleher, James J. La Clair, Michael Rothmann
Publikováno v:
Journal of the American Chemical Society. 135(16)
Pantetheine, and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA), an essential cofactor utilized in ~4% of primary metabolism and central to fatty acid, polyketide, and non-ribosomal pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cd0ed4a1875515f7f6c1b8ce06dc0f
https://pubmed.ncbi.nlm.nih.gov/23550886
https://pubmed.ncbi.nlm.nih.gov/23550886
Autor:
Larisa Balaian, Michael D. Burkart, Anna A. Kulidjian, James J. La Clair, Nathaniel Delos Santos, Reymundo Villa, Sheldon R. Morris, Maria A. Zipeto, Catriona Jamieson, Edward D. Ball, Heather Leu, Anil Sadarangani, Angela C. Court, Leslie Crews, Rainer Storb
Publikováno v:
Cancer Research. 76:915-915
Introduction: Human bone marrow aging is typified by decreased cellularity, stem cell exhaustion and myeloid lineage bias that may set the stage for development of myeloid malignancies. Secondary AML (sAML) is a malignancy that has been associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e9a9e00dfd0a63d373a6a62d97836f
https://doi.org/10.1158/1538-7445.am2016-915
https://doi.org/10.1158/1538-7445.am2016-915
Autor:
Edward D. Ball, Reymundo Villa, Anil Sadarangani, Maria A. Zipeto, Leslie Crews, Anna A. Kulidjian, Michael D. Burkart, Angela C. Court, Nathaniel Delos Santos, Heather Leu, James J. La Clair, Sheldon R. Morris, Larissa Balaian, Catriona Jamieson, Rainer Storb
Publikováno v:
Blood. 126:567-567
Introduction Disease relapse is the leading cause of death in secondary AML (sAML), which evolves from antecedent hematologic disorders like myelodysplastic syndrome (MDS) or myeloproliferative neoplasms (MPNs) or following exposure to chemotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::144a1b180a0fdebc6383269fc0a90133
https://doi.org/10.1182/blood.v126.23.567.567
https://doi.org/10.1182/blood.v126.23.567.567
Autor:
Thomas J. Kipps, Reymundo Villa, Michael D. Burkat, Manoj Kumar Kashyap, Ide Spaanderman, Deepak Kumar, Laura Z. Rassenti, Januario E. Castro, James J. La Clair
Publikováno v:
Blood. 122:2884-2884
Abnormalities in RNA splicing have been implicated in tumorigenesis and cancer progression. Recent studies have defined RNA splicing as in attractive target for development of effective anticancer therapy. However, significant hurdles need to be solv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee7fbe3473f4e5ed2063175e8324a7d
https://doi.org/10.1182/blood.v122.21.2884.2884
https://doi.org/10.1182/blood.v122.21.2884.2884