Population pharmacokinetics and exposure-response analyses of safety (ARIA-E and isolated ARIA-H) of lecanemab in subjects with early Alzheimer's disease.

Autor: Majid O; Eisai Ltd., Hatfield, UK., Cao Y; Eisai Inc., Nutley, New Jersey, USA., Willis BA; Eisai Inc., Nutley, New Jersey, USA., Hayato S; Eisai Co., Ltd., Tokyo, Japan., Takenaka O; Eisai Co., Ltd., Tokyo, Japan., Lalovic B; Eisai Inc., Nutley, New Jersey, USA., Sreerama Reddy SH; Eisai Inc., Nutley, New Jersey, USA., Penner N; Eisai Inc., Nutley, New Jersey, USA., Reyderman L; Eisai Inc., Nutley, New Jersey, USA., Yasuda S; Eisai Co., Ltd., Tokyo, Japan., Hussein Z; Eisai Ltd., Hatfield, UK.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Dec; Vol. 13 (12), pp. 2111-2123. Date of Electronic Publication: 2024 Aug 29.

Plasma pTau217 predicts continuous brain amyloid levels in preclinical and early Alzheimer's disease.

Autor: Devanarayan V; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA.; Department of Mathematics, Statistics and Computer Science, University of Illinois Chicago, Chicago, Illinois, USA., Doherty T; Eisai Ltd., Clinical Evidence Generation, Hatfield, UK., Charil A; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA., Sachdev P; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA., Ye Y; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA., Murali LK; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA., Llano DA; Carle Illinois College of Medicine, Urbana, Illinois, USA.; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute for Advanced Science and Technology, Urbana, Illinois, USA., Zhou J; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA., Reyderman L; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA., Hampel H; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA., Kramer LD; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA., Dhadda S; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA., Irizarry MC; Eisai Inc., Clinical Evidence Generation, Nutley, New Jersey, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Aug; Vol. 20 (8), pp. 5617-5628. Date of Electronic Publication: 2024 Jun 28.

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Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease.

Autor: Horie K; Department of Neurology, Washington University School of Medicine, Saint Louis, MO.; Eisai Inc., Nutley, NJ.; The Tracy Family SILQ Center, Washington University School of Medicine, St. Louis, MO., Li Y; Department of Neurology, Washington University School of Medicine, Saint Louis, MO., Barthélemy NR; Department of Neurology, Washington University School of Medicine, Saint Louis, MO.; The Tracy Family SILQ Center, Washington University School of Medicine, St. Louis, MO., Gordon B; Department of Radiology, Washington University School of Medicine, St. Louis, MO., Hassenstab J; Department of Neurology, Washington University School of Medicine, Saint Louis, MO., Benzinger TLS; Department of Radiology, Washington University School of Medicine, St. Louis, MO., Fagan AM; Department of Neurology, Washington University School of Medicine, Saint Louis, MO., Morris JC; Department of Neurology, Washington University School of Medicine, Saint Louis, MO., Karch CM; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO., Xiong C; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO., Allegri R; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Instituto de Investigaciones Neurológicas Raúl Correa, Buenos Aires, Argentina., Mendez PC; Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Instituto de Investigaciones Neurológicas Raúl Correa, Buenos Aires, Argentina., Ikeuchi T; Niigata University, Niigata, Japan., Kasuga K; Niigata University, Niigata, Japan., Noble J; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, G.H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY., Farlow M; Department of Neurology, Indiana University, Indianapolis, IN., Chhatwal J; Massachusetts General Hospital, Harvard Medical School Boston, Boston, MA., Day G; Department of Neurology, Mayo Clinic in Florida, Jacksonville, FL., Schofield PR; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Masters CL; The Florey Institute and the University of Melbourne, Parkville, Victoria, Australia., Levin J; German Center for Neurodegenerative Diseases (DZNE) Munich, Munchen, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, Ludwig-Maximilians Universität München, Munich, Germany., Jucker M; German Center for Neurodegenerative Diseases (DZNE) Tübingen, and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Lee JH; Department of Neurology, Asan Medical Center, Seoul, Korea., Roh JH; Departments of Biomedical Sciences, Physiology, and Neurology, Korea University College of Medicine, Seoul, Korea., Sato C; Department of Neurology, Washington University School of Medicine, Saint Louis, MO.; The Tracy Family SILQ Center, Washington University School of Medicine, St. Louis, MO., Sachdev P; Eisai Inc., Nutley, NJ., Koyama A; Eisai Inc., Nutley, NJ., Reyderman L; Eisai Inc., Nutley, NJ., Bateman RJ; Department of Neurology, Washington University School of Medicine, Saint Louis, MO.; The Tracy Family SILQ Center, Washington University School of Medicine, St. Louis, MO., McDade E; Department of Neurology, Washington University School of Medicine, Saint Louis, MO.

Publikováno v: Annals of neurology [Ann Neurol] 2023 Jun; Vol. 93 (6), pp. 1158-1172. Date of Electronic Publication: 2023 Mar 16.

A combined physiologically-based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease.

Autor: Geerts H; Certara QSP-UK, Canterbury, UK., Walker M; Certara QSP-UK, Canterbury, UK., Rose R; Certara QSP-UK, Canterbury, UK., Bergeler S; Certara QSP-UK, Canterbury, UK., van der Graaf PH; Certara QSP-UK, Canterbury, UK., Schuck E; Schrodinger Inc., New York City, New York, USA., Koyama A; Eisai Inc., Nutley, New Jersey, USA., Yasuda S; Eisai Inc., Nutley, New Jersey, USA., Hussein Z; Eisai Ltd., Hatfield, UK., Reyderman L; Eisai Inc., Nutley, New Jersey, USA., Swanson C; Eisai Inc., Nutley, New Jersey, USA., Cabal A; Eisai Inc., Nutley, New Jersey, USA.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Apr; Vol. 12 (4), pp. 444-461. Date of Electronic Publication: 2023 Jan 20.