Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Reyaz Ur, Rasool"'
Autor:
Takeshi Katsuda, Jonathan H. Sussman, Kenji Ito, Andrew Katznelson, Salina Yuan, Naomi Takenaka, Jinyang Li, Allyson J. Merrell, Hector Cure, Qinglan Li, Reyaz Ur Rasool, Irfan A. Asangani, Kenneth S. Zaret, Ben Z. Stanger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Tissue damage elicits cell fate switching through a process called metaplasia, but how the starting cell fate is silenced and the new cell fate is activated has not been investigated in animals. In cell culture, pioneer transcription factors
Externí odkaz:
https://doaj.org/article/b2c5a3c430084dd3bae1dbe3580360ff
Autor:
Reyaz ur Rasool, Caitlin M. O’Connor, Chandan Kanta Das, Mohammed Alhusayan, Brijesh Kumar Verma, Sehbanul Islam, Ingrid E. Frohner, Qu Deng, Erick Mitchell-Velasquez, Jaya Sangodkar, Aqila Ahmed, Sarah Linauer, Ingrid Mudrak, Jessica Rainey, Kaitlin P. Zawacki, Tahra K. Suhan, Catherine G. Callahan, Ryan Rebernick, Ramakrishnan Natesan, Javed Siddiqui, Guido Sauter, Dafydd Thomas, Shaomeng Wang, Derek J. Taylor, Ronald Simon, Marcin Cieslik, Arul M. Chinnaiyan, Luca Busino, Egon Ogris, Goutham Narla, Irfan A. Asangani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Loss of the tumor suppressive activity of the protein phosphatase 2A (PP2A) is associated with cancer, but the underlying molecular mechanisms are unclear. PP2A holoenzyme comprises a heterodimeric core, a scaffolding A subunit and a catalyt
Externí odkaz:
https://doaj.org/article/7ea3b219c8a941b89ece9e99f3bc0149
Autor:
Qu Deng, Ramakrishnan Natesan, Florencia Cidre-Aranaz, Shehbeel Arif, Ying Liu, Reyaz ur Rasool, Pei Wang, Erick Mitchell-Velasquez, Chandan Kanta Das, Endrit Vinca, Zvi Cramer, Patrick J. Grohar, Margaret Chou, Chandan Kumar-Sinha, Kristy Weber, T.S. Karin Eisinger-Mathason, Nicolas Grillet, Thomas Grünewald, Irfan A. Asangani
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110971- (2022)
Summary: Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic transcription prog
Externí odkaz:
https://doaj.org/article/28e40682ce2f41f69b105d59455a86a7
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102254- (2021)
Summary: Epidemiological data showing increased severity and mortality of COVID-19 in men suggests a potential role for androgen in SARS-CoV-2 infection. Here, we present evidence for the transcriptional regulation of SARS-CoV-2 host cell receptor AC
Externí odkaz:
https://doaj.org/article/5d33409195584a248853fc15987a68ba
Autor:
Irfan A. Asangani, Donita C. Brady, Matthew L. Freedman, Robert B. Den, Goutham Narla, Nallasivam Palanisamy, Daniel J. Lee, Lauren E. Schwartz, Javed Siddiqui, Mark M. Pomerantz, Sylvan C. Baca, Shannon Carskadon, Jessica M. Posimo, Erick Mitchell-Velasquez, Samuel Sander Effron, Priti Lal, Shweta Aras, Qu Deng, Ramakrishnan Natesan, Reyaz ur Rasool
Supplementary Figures S1-S12, Supplementary Table S1-3, supplementary methods and reference.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428b1ea3328b07aa415fc411cd6fc9e5
https://doi.org/10.1158/2159-8290.22535924
https://doi.org/10.1158/2159-8290.22535924
Autor:
Irfan A. Asangani, Donita C. Brady, Matthew L. Freedman, Robert B. Den, Goutham Narla, Nallasivam Palanisamy, Daniel J. Lee, Lauren E. Schwartz, Javed Siddiqui, Mark M. Pomerantz, Sylvan C. Baca, Shannon Carskadon, Jessica M. Posimo, Erick Mitchell-Velasquez, Samuel Sander Effron, Priti Lal, Shweta Aras, Qu Deng, Ramakrishnan Natesan, Reyaz ur Rasool
Metastatic castration-resistant prostate cancer (CRPC) is a fatal disease, primarily resulting from the transcriptional addiction driven by androgen receptor (AR). First-line CRPC treatments typically target AR signaling, but are rapidly bypassed, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fdbfe9bee4ee9a1af227f8fe379b406
https://doi.org/10.1158/2159-8290.c.6547985.v1
https://doi.org/10.1158/2159-8290.c.6547985.v1
Autor:
Takeshi Katsuda, Jonathan Sussman, Kenji Ito, Andrew Katznelson, Salina Yuan, Jinyang Li, Allyson J. Merrell, Naomi Takenaka, Hector Cure, Qinglan Li, Reyaz Ur Rasool, Irfan A. Asangani, Kenneth S. Zaret, Ben Z. Stanger
Publikováno v:
bioRxiv
Tissue damage elicits cell fate switching through a process called metaplasia, but how the starting cell fate is silenced and the new cell fate is activated has not been investigated in animals. In cell culture, pioneer transcription factors mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238acba009c89fc2901466e41448f5c9
https://europepmc.org/articles/PMC9948957/
https://europepmc.org/articles/PMC9948957/
Autor:
Mir Mohd Faheem, Nathan D. Seligson, Reyaz ur Rasool, Madhulika Bhagat, Syed Mudabir Ahmad, Sumit G. Gandhi, Anindya Goswami
Publikováno v:
Cell Death Discovery, Vol 6, Iss 1, Pp 1-12 (2020)
Cell Death Discovery
Cell Death Discovery
Drug induced resistance is a widespread problem in the clinical management of cancer. Cancer cells, when exposed to cytotoxic drugs, can reprogram their cellular machinery and resist cell death. Evasion of cell death mechanisms, such as apoptosis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e33efd38d06cce5edb6e68d01190704
http://link.springer.com/article/10.1038/s41420-020-0286-z
http://link.springer.com/article/10.1038/s41420-020-0286-z
Publikováno v:
Cancer Discov
Resistance to androgen receptor (AR) blockade in castration resistant prostate cancer (CRPC) is associated with sustained AR signaling, including through alternative splicing of the AR (AR-SV). Inhibitors of transcriptional co-activators that regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798d51e6a3ec585a88d4888720d4cc5d
https://doi.org/10.1158/2159-8290.cd-21-0184
https://doi.org/10.1158/2159-8290.cd-21-0184
Autor:
Qu Deng, Ramakrishnan Natesan, Florencia Cidre-Aranaz, Shehbeel Arif, Ying Liu, Reyaz ur Rasool, Pei Wang, Erick Mitchell-Velasquez, Chandan Kanta Das, Endrit Vinca, Zvi Cramer, Patrick J. Grohar, Margaret Chou, Chandan Kumar-Sinha, Kristy Weber, T.S. Karin Eisinger-Mathason, Nicolas Grillet, Thomas G.P. Grünewald, Irfan A. Asangani
Publikováno v:
Cell reports. 39(11)
Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic transcription program throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d54b815d1ef9e26b11df9d43f527a0
https://pubmed.ncbi.nlm.nih.gov/35705030
https://pubmed.ncbi.nlm.nih.gov/35705030