Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Rey-Ting Guo"'
Autor:
Chengsen Cui, Lu-Jia Yang, Zi-Wei Liu, Xian Shu, Wei-Wei Zhang, Yuan Gao, Yu-Xuan Wang, Te Wang, Chun-Chi Chen, Rey-Ting Guo, Shu-Shan Gao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The inversion of substrate size specificity is an evolutionary roadblock for proteins. The Duf4243 dioxygenases GedK and BTG13 are known to catalyze the aromatic cleavage of bulky tricyclic hydroquinone. In this study, we discover a Duf4243
Externí odkaz:
https://doaj.org/article/ffbb5d0c0d66463cba3c33acf19444f2
Publikováno v:
Advanced Agrochem, Vol 3, Iss 2, Pp 126-132 (2024)
Poly (butylene adipate-co-terephthalate), PBAT, is one of the most popular plastics nowadays and is becoming a large burden to the environment when PBAT waste is accumulated. Biodegradation of PBAT is an environmentally friendly method to treat PBAT
Externí odkaz:
https://doaj.org/article/e2a53a8013764521aa05d360f610e636
Publikováno v:
Acta Materia Medica, Vol 3, Iss 1, Pp 57-71 (2024)
Endocrine therapy that blocks estrogen receptor signaling has been effective for decades as a primary treatment choice for breast cancer patients expressing the estrogen receptor. However, the issue of drug resistance poses a significant clinical cha
Externí odkaz:
https://doaj.org/article/a720e144bdbd48b290ccb3685f9b95a3
Autor:
Yubo Wang, Jian Min, Xiangping Deng, Tian Feng, Hebing Hu, Xinyi Guo, Yan Cheng, Baohua Xie, Yu Yang, Chun-Chi Chen, Rey-Ting Guo, Chune Dong, Hai-Bing Zhou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 4963-4982 (2023)
Endocrine-resistance remains a major challenge in estrogen receptor α positive (ERα+) breast cancer (BC) treatment and constitutively active somatic mutations in ERα are a common mechanism. There is an urgent need to develop novel drugs with new m
Externí odkaz:
https://doaj.org/article/f84e6d8203d24831bb9c9b09d3cda2b2
Autor:
Hao Li, Jian-Wen Huang, Longhai Dai, Haibin Zheng, Si Dai, Qishan Zhang, Licheng Yao, Yunyun Yang, Yu Yang, Jian Min, Rey-Ting Guo, Chun-Chi Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract The biosynthesis of neurotoxin aetokthonotoxin (AETX) that features a unique structure of pentabrominated biindole nitrile involves a first-of-its-kind nitrile synthase termed AetD, an enzyme that shares very low sequence identity to known s
Externí odkaz:
https://doaj.org/article/f7d5b80f288c4ed4b179b1eeec5e85ef
Autor:
Zhong Li, Lilan Zhang, Kangwei Xu, Yuanyuan Jiang, Jieke Du, Xingwang Zhang, Ling-Hong Meng, Qile Wu, Lei Du, Xiaoju Li, Yuechan Hu, Zhenzhen Xie, Xukai Jiang, Ya-Jie Tang, Ruibo Wu, Rey-Ting Guo, Shengying Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Diterpene synthase VenA is responsible for assembling venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also demonstrates substrate promiscuity by accepting geranyl pyrophosphate and farnesyl p
Externí odkaz:
https://doaj.org/article/edd63d160b41477f8f37ff2ed99ab384
Autor:
Xian Li, Beilei Shi, Jian-Wen Huang, Ziyin Zeng, Yu Yang, Lilan Zhang, Jian Min, Chun-Chi Chen, Rey-Ting Guo
Publikováno v:
Bioresources and Bioprocessing, Vol 10, Iss 1, Pp 1-11 (2023)
Abstract Using enzymes to hydrolyze and recycle poly(ethylene terephthalate) (PET) is an attractive eco-friendly approach to manage the ever-increasing PET wastes, while one major challenge to realize the commercial application of enzyme-based PET de
Externí odkaz:
https://doaj.org/article/864c977c37264bf199739ae3bf3488a2
Autor:
Yu Yang, Jian Min, Ting Xue, Pengcheng Jiang, Xin Liu, Rouming Peng, Jian-Wen Huang, Yingying Qu, Xian Li, Ning Ma, Fang-Chang Tsai, Longhai Dai, Qi Zhang, Yingle Liu, Chun-Chi Chen, Rey-Ting Guo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Bio-degradation of poly(butylene adipate-co-terephthalate) is an attractive tactic but requires an effective hydrolytic enzyme. Here, the authors demonstrate that cutinases are highly potent PBAT-decomposing enzymes and their mechanism is proposed ba
Externí odkaz:
https://doaj.org/article/366e1d99d08046f9b6e8aa5de7f891b6
Autor:
Zhongwei Mao, Hongying Xiao, Panpan Shen, Yu Yang, Jing Xue, Yunyun Yang, Yanguo Shang, Lilan Zhang, Xin Li, Yuying Zhang, Yanan Du, Chun-Chi Chen, Rey-Ting Guo, Yonghui Zhang
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract KRAS mutation occurs in nearly 30% of human cancers, yet the most prevalent and oncogenic KRAS(G12D) variant still lacks inhibitors. Herein, we designed a series of potent inhibitors that can form a salt bridge with KRAS’s Asp12 residue. O
Externí odkaz:
https://doaj.org/article/b89d9fc49b0d496ab0b69418cf6827ab
Autor:
Lilan Zhang, Zhenzhen Xie, Ziwei Liu, Shuyu Zhou, Lixin Ma, Weidong Liu, Jian-Wen Huang, Tzu-Ping Ko, Xiuqin Li, Yuechan Hu, Jian Min, Xuejing Yu, Rey-Ting Guo, Chun-Chi Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Self-sufficient cytochrome P450 monooxygenases, which contain all redox partners in a single polypeptide chain, are of interest for biotechnological applications. Here, the authors present the crystal structure of full-length Thermobispora bispora CY
Externí odkaz:
https://doaj.org/article/25583d0860a44241a350fa6add954485