Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rey P Dimas"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Genetic sensors can be created by mix and matching DNA-binding modules with ligand-binding modules. Here the authors use a computational model to overcome module incompatibilities and restore function by rescuing key interactions.
Externí odkaz:
https://doaj.org/article/cec9375bf6eb42b9bab94705b00a26b9
Autor:
Dustin P. Patterson, Xian-Li Jiang, Joseph S. Glavy, Clement T Y Chan, Benjamin R Jordan, Rey P Dimas, Catherine Martini, Faruck Morcos
Publikováno v:
Nucleic Acids Research
The development of synthetic biological systems requires modular biomolecular components to flexibly alter response pathways. In previous studies, we have established a module-swapping design principle to engineer allosteric response and DNA recognit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbc39bd31d6a0096d51316a71101c03
http://europepmc.org/articles/PMC6895282
http://europepmc.org/articles/PMC6895282
Publikováno v:
Nucleic Acids Research
Engineering allosteric transcriptional repressors containing an environmental sensing module (ESM) and a DNA recognition module (DRM) has the potential to unlock a combinatorial set of rationally designed biological responses. We demonstrated that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160121a48564a9fb1fba0def7dc6cc71
http://europepmc.org/articles/PMC6547410
http://europepmc.org/articles/PMC6547410