Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rexan Rodrigo"'
Autor:
Nirmani Yasara, Nethmi Wickramarathne, Chamila Mettananda, Ishari Silva, Nizri Hameed, Kumari Attanayaka, Rexan Rodrigo, Nirmani Wickramasinghe, Lakshman Perera, Aresha Manamperi, Anuja Premawardhena, Sachith Mettananda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness in β-thalassaemia is unproven. We conducted a randomised, double-blind, placebo-controlled clinical trial to evalu
Externí odkaz:
https://doaj.org/article/4cc1a47132c94b1ba3eb73830eb877e0
Autor:
Thamal Darshana, Dayananda Bandara, Upul Nawarathne, Udaya de Silva, Yasinta Costa, Kalavitigoda Pushpakumara, Sumithra Pathirage, Seuwandi Basnayake, Chamila Epa, Pradeepa Dilrukshi, Maheshaka Wijayawardena, Angela A. Anthony, Rexan Rodrigo, Aresha Manamperi, Frances Smith, Angela Allen, Stephan Menzel, David Rees, Anuja Premawardhena
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-9 (2020)
Abstract Background Though case reports and limited case series of Sickle cell disease in Sri Lanka have been reported previously, no attempt has been made hitherto to undertake a comprehensive genotypic-phenotypic analysis of this “rare” group o
Externí odkaz:
https://doaj.org/article/235f38c87dfa4b928d192bd1a390279a
Autor:
Angela Allen, Shiromi Perera, Luxman Perera, Rexan Rodrigo, Sachith Mettananda, Agnes Matope, Ishari Silva, Nizri Hameed, Christopher A. Fisher, Nancy Olivieri, David J. Weatherall, Stephen Allen, Anuja Premawardhena
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Introduction: The high frequencies of carriers of severe haemoglobinopathies and of iron deficiency in Southeast Asia require reliable and affordable tests to improve on current screening procedures.Objectives: We evaluate a “one stop” approach u
Externí odkaz:
https://doaj.org/article/2d30e2530cdb4a3cb214af3e58fd6ca2
Autor:
Sachith Mettananda, Marius Suranjan, Roshale Fernando, Tiran Dias, Chamila Mettananda, Rexan Rodrigo, Lakshman Perera, Richard Gibbons, Anuja Premawardhena, Douglas Higgs
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206928 (2018)
IntroductionAnaemia in women during pregnancy and child bearing age is one of the most common global health problems. Reasons are numerous, but in many cases only minimal attempts are made to elucidate the underlying causes. In this study we aim to i
Externí odkaz:
https://doaj.org/article/616a5a9352fc4135b6890981a0e3f17d
Autor:
Angela Allen, Stephen Allen, Rexan Rodrigo, Lakshman Perera, Wei Shao, Chao Li, Duolao Wang, Nancy Olivieri, David J Weatherall, Anuja Premawardhena
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188110 (2017)
BackgroundIron deficiency, the most common micronutrient disorder and cause of anaemia globally, impairs growth, cognition, behaviour and resistance to infection.Methods/resultsAs part of a national survey of inherited haemoglobin variants in 7526 st
Externí odkaz:
https://doaj.org/article/dfbee8e342db4847b84901e258defdff
Autor:
Thamal Darshana, Sachith Mettananda, Lesley Heirene, David C. Rees, Anuja Premawardhena, Rexan Rodrigo, Stephen Allen, Fiona Moggach, Anthony Jackson Crawford, Lakshman Perera, S. Perera, Chris Fisher, Angela Allen, Nancy F. Olivieri
Publikováno v:
Free Radical Biology and Medicine. 166:337-347
In the β-thalassemias, oxidative stress, resulting from chronic hemolysis, globin chain imbalance, iron overload and depleted antioxidant defences, likely contributes to cell death, organ damage, anemia, hypoxia and inflammation. We assessed variati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b033cb8d0887723df3fc6b455ce7b8e
https://doi.org/10.1016/j.freeradbiomed.2021.02.028
https://doi.org/10.1016/j.freeradbiomed.2021.02.028
Autor:
Dayananda Bandara, Kalavitigoda Pushpakumara, Frances Smith, Udaya de Silva, Stephan Menzel, A. Manamperi, Pradeepa Dilrukshi, Maheshaka Wijayawardena, Anuja Premawardhena, Thamal Darshana, Rexan Rodrigo, Sumithra Pathirage, Angela A. Anthony, Upul Nawarathne, Seuwandi Basnayake, David C. Rees, Chamila Epa, Angela Allen, Yasinta Costa
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-9 (2020)
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases
Background Though case reports and limited case series of Sickle cell disease in Sri Lanka have been reported previously, no attempt has been made hitherto to undertake a comprehensive genotypic-phenotypic analysis of this “rare” group of patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8eb7006a0e07decfc0757f62f07646
http://link.springer.com/article/10.1186/s13023-020-01458-w
http://link.springer.com/article/10.1186/s13023-020-01458-w
Autor:
Nirmani Yasara, Nethmi Wickramarathne, Chamila Mettananda, Ishari Silva, Nizri Hameed, Kumari Attanayaka, Rexan Rodrigo, Nirmani Wickramasinghe, Lakshman Perera, Aresha Manamperi, Anuja Premawardhena, Sachith Mettananda
Publikováno v:
Scientific reports. 12(1)
Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness in β-thalassaemia is unproven. We conducted a randomised, double-blind, placebo-controlled clinical trial to evaluate the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bc27d3f93eaf04933770c88b8dd5a7
https://pubmed.ncbi.nlm.nih.gov/35177777
https://pubmed.ncbi.nlm.nih.gov/35177777
Autor:
Anuja Premawardhena, Lakshman Perera, B K T P Dayanath, Roshale Fernando, Marius Suranjan, Sanjaya Paranamana, Yasintha Costa, Rexan Rodrigo, Prasanna Fernando, Sachith Mettananda, Thakshila Vipulaguna, Mallika Fernando
Publikováno v:
Pediatric hematology and oncology. 37(4)
Microcytic anemia in children is commonly attributed to iron deficiency without attempting to find the cause. Inadequate investigations to exclude hemoglobinopathies lead to missed opportunities for identification of thalassemia carriers. Here we aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad3102c49d52d13017a5b9da0b4f118
https://pubmed.ncbi.nlm.nih.gov/32072846
https://pubmed.ncbi.nlm.nih.gov/32072846
Autor:
Angela Allen, Anuja Premawardhena, Rexan Rodrigo, Chris Fisher, Aresha Manampreri, David J. Weatherall, Stephen Allen, Luxman Perera
Publikováno v:
Blood Cells, Molecules, and Diseases. 71:11-15
Iron deficiency complicates the use of red cell indices to screen for carriers of haemoglobin variants in many populations. In a cross sectional survey of 7526 secondary school students from 25 districts of Sri Lanka, 1963 (26.0%) students had low re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67b72dbfb47005569b6d0f375290918
https://doi.org/10.1016/j.bcmd.2018.01.003
https://doi.org/10.1016/j.bcmd.2018.01.003