Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Rex S. Clements"'
Autor:
Rex S. Clements, Elizabeth Hud, Fuad N. Ziyadeh, Margo P. Cohen, Nicole Masson, Dong Cheol Han
Publikováno v:
Nephron Experimental Nephrology. 8:135-143
Albumin modified by Amadori glucose adducts stimulates the expression of extracellular matrix proteins by glomerular mesangial and endothelial cells, and has been mechanistically linked to the pathogenesis of diabetic nephropathy. To test the hypothe
Autor:
Margo P. Cohen, Rex S. Clements
Publikováno v:
Diabetes Technology & Therapeutics. 1:57-70
The recognition that nonenzymatic glycation, wherein free sugar condenses with certain reactive protein amino groups, is increased in hyperglycemic states has led to improved means for assessing diabetic control through the measurement of concentrati
Publikováno v:
Journal of Diabetes and its Complications. 12:28-33
Hyperglycemia plays a primary causal role in the early vascular damage leading to diabetic retinopathy, but the intermediate biochemical mechanisms involved are not known. Because albumin modified by Amadori glucose adducts has been implicated in the
Autor:
Rex S. Clements, Douglas A. Greene, Joseph C. Arezzo, Edward W. Munster, David A. Gelber, Harry Shamoon, Daniel Porte, Adina Zeidler, Vera Bril, Michael A. Pfeifer, Michael J. Peterson, Charles Laudadio, Vasti L. Broadstone
Publikováno v:
Journal of Diabetes and its Complications. 9:170-176
Quantitative sensory testing (QST) is commonly used in the assessment of diabetic neuropathy. However, little data are available on the reliability of tactile and thermal testing devices. Reproducibility of QST measures between centers has not been p
Publikováno v:
Diabetologia. 39(3)
We recently reported that when diabetic db/db mice, which develop glomerular pathology resembling that in human diabetes mellitus, are treated with monoclonal antibodies (A717) that neutralize the effects of excess glycated albumin, there is an ameli
Publikováno v:
Biochemical and biophysical research communications. 218(1)
Increased protein glycation has been mechanistically linked to accelerated vascular pathobiology in diabetes. Because glycated albumin induces biosynthetic abnormalities in cultured aortic endothelial cells that resemble those associated with macrova
Autor:
Rex S. Clements
Publikováno v:
Journal of Diabetes and its Complications. 7:90-91
Publikováno v:
Diabetes Care. 15:723-724
Publikováno v:
Archives of Internal Medicine. 151:2265
The accuracy of patients and health care professionals in drawing up the components of a split-mix insulin regimen and of premixed insulin at three dosages (30 units, 10 units, and 5 units) was assessed with both 30-U and 100-U syringes. Both patient
Publikováno v:
The Journal of Pediatrics. 117:340