Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Rex Kerr"'
Autor:
Antoine Emile Roux, Han Yuan, Katie Podshivalova, David Hendrickson, Rex Kerr, Cynthia Kenyon, David Kelley
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112902- (2023)
Summary: Aging is characterized by a global decline in physiological function. However, by constructing a complete single-cell gene expression atlas, we find that Caenorhabditis elegans aging is not random in nature but instead is characterized by co
Externí odkaz:
https://doaj.org/article/86eb033c73b645c1947c6a7629f7bb5d
Autor:
Antoine E. Roux, Han Yuan, Katie Podshivalova, David Hendrickson, Rex Kerr, Cynthia Kenyon, David R. Kelley
Here we describe a single-cell atlas of aging for the nematode Caenorhabditis elegans. This unique resource describes the expression across adulthood of over 20,000 genes among 211 groups of cells that correspond to virtually every cell type in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc262fdd7c0a8f17a871901dca0de44d
https://doi.org/10.1101/2022.06.15.496201
https://doi.org/10.1101/2022.06.15.496201
Autor:
Chee Wai Lee, Michael Currie, André Ex Brown, Eviatar Yemini, Avelino Javer, Ellen A. A. Nollen, Rex Kerr, Jim Hokanson, Quee-Lim Ch'ng, Chris Li, Laura J Grundy, Celine N. Martineau, William R Schafer, Kezhi Li
Publikováno v:
Nature Methods, 15(9), 645-646. Nature Publishing Group
Animal behavior is increasingly being recorded in systematic imaging studies that generate large data sets. To maximize the usefulness of these data there is a need for improved resources for analyzing and sharing behavior data that will encourage re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93e27f24305e6ba830a76f52a27e4c6
Autor:
Marta Zlatic, Joshua T. Vogelstein, Carey E. Priebe, Youngser Park, James W. Truman, Tomoko Ohyama, Rex Kerr
Publikováno v:
Science. 344:386-392
Optogenetic Insights Mapping functional neural circuits for many behaviors has been almost impossible, so Vogelstein et al. (p. 386 , published online 27 March; see the Perspective by O'Leary and Marder ) developed a broadly applicable optogenetic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec2fdb241d4e014125ef09100587591
https://doi.org/10.1126/science.1250298
https://doi.org/10.1126/science.1250298
Autor:
Stefan R. Pulver, Tsai Wen Chen, Amy Baohan, Yi Sun, Sabine L. Renninger, Karel Svoboda, Rex Kerr, Trevor J. Wardill, Eric R. Schreiter, Michael B. Orger, Douglas S. Kim, Loren L. Looger, Vivek Jayaraman
Publikováno v:
Nature. 499:295-300
Fluorescent calcium sensors are widely used to image neural activity. Using structure-based mutagenesis and neuron-based screening, we developed a family of ultrasensitive protein calcium sensors (GCaMP6) that outperformed other sensors in cultured n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93e23df750302fb47bb15420ff17dfb0
https://doi.org/10.1038/nature12354
https://doi.org/10.1038/nature12354
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 441-450 (2017)
Summary: The goal of aging research is to extend healthy, active life. For decades, C. elegans daf-2 insulin/insulin-like growth factor 1 (IGF-1) receptor mutants have served as a model for extended lifespan and youthfulness. However, a recent report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e82a1a0e068ed7ba1239f2342aa671
https://pubmed.ncbi.nlm.nih.gov/28423308
https://pubmed.ncbi.nlm.nih.gov/28423308
Autor:
Eiji Shigetomi, Sevinç Mutlu, Andrew Gordus, Florian Engert, Loren L. Looger, John J. Macklin, Eric R. Schreiter, Aman Aggarwal, Nicole Carreras Calderón, Bruce E. Kimmel, Samuel S.-H. Wang, Douglas S. Kim, Herwig Baier, Leon Lagnado, Sebastian Kracun, Karel Svoboda, Baljit S. Khakh, Xiaonan Richard Sun, Trevor J. Wardill, Ruben Portugues, Lin Tian, Cornelia I. Bargmann, Vivek Jayaraman, Federico Esposti, Bart G. Borghuis, Jonathan S. Marvin, Alessandro Filosa, Tsai Wen Chen, Ryousuke Takagi, Michael B. Orger, Jasper Akerboom, Rex Kerr
Publikováno v:
The Journal of Neuroscience. 32:13819-13840
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased the performance of GECIs. The state-of-the art single-wavelength GECI, GCaMP3, has been dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f129ce07ec26e102a535bad97cbf711
https://doi.org/10.1523/jneurosci.2601-12.2012
https://doi.org/10.1523/jneurosci.2601-12.2012
Publikováno v:
Nature methods
The Multi-Worm Tracker permits real-time, high-throughput, quantitative analysis of behavior in Caenorhabditis elegans. It should enable screens for genes implicated in complex worm behaviors. Also in this issue, Albrecht and Bargmann apply microflui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081ff19536729aa0ae7d096e3e221062
https://doi.org/10.1038/nmeth.1625
https://doi.org/10.1038/nmeth.1625
Autor:
William R Schafer, Robyn Branicky, Jana F. Liewald, Rex Kerr, Alexander Gottschalk, Victoria J. Butler, Eviatar Yemini, Dmitri B. Chklovskii
Publikováno v:
Journal of the Royal Society Interface
Although undulatory swimming is observed in many organisms, the neuromuscular basis for undulatory movement patterns is not well understood. To better understand the basis for the generation of these movement patterns, we studied muscle activity in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f190d1fc0e01c7b78c2cd7550c371008
http://europepmc.org/articles/PMC4277086
http://europepmc.org/articles/PMC4277086
Autor:
Christian Frøkjær-Jensen, Katie S. Kindt, Katya V. Melnik-Martinez, Monica Driscol, Hiroshi Suzuki, Beate Gerstbreih, Rex Kerr, William R Schafer
Publikováno v:
Journal of Neurobiology. 66:1125-1139
Voltage-gated calcium channels (VGCCs) serve as a critical link between electrical signaling and diverse cellular processes in neurons. We have exploited recent advances in genetically encoded calcium sensors and in culture techniques to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98713a9769087691791d59291b54f263
https://doi.org/10.1002/neu.20261
https://doi.org/10.1002/neu.20261