Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Rex A. Pegram"'
Publikováno v:
Toxicol In Vitro
Metabolic rate parameters estimation using in vitro data is necessary due to numbers of chemicals for which data are needed, trend towards minimizing laboratory animal use, and limited opportunity to collect data in human subjects. We evaluated how w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefca253c8768d56daa2aee3b989bd6e
https://europepmc.org/articles/PMC8607508/
https://europepmc.org/articles/PMC8607508/
Publikováno v:
Toxicology in Vitro. 75:105045
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cbb2499c21177a36584988832ae7956
https://doi.org/10.1016/j.tiv.2020.105045
https://doi.org/10.1016/j.tiv.2020.105045
Publikováno v:
Toxicology Mechanisms and Methods. 26:620-626
A rate for hepatic metabolism (Vmax) determined in vitro must be scaled for in vivo use in a physiologically based pharmacokinetic (PBPK) model. This requires the use of scaling factors such as mg of microsomal protein per gram of liver (MPPGL) and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea9dd6428614e69060e030695c0337d
https://doi.org/10.1080/15376516.2016.1225141
https://doi.org/10.1080/15376516.2016.1225141
Autor:
Charles A. Wilson, Edward L. Croom, Lider S. Leon, Lauren J. Beesley, Chris R. Eklund, Rex A. Pegram, Megan E. Sawyer, Marina V. Evans
Publikováno v:
Toxicology Letters. 245:106-109
Lindane is a neurotoxicant used for the treatment of lice and scabies present on human skin. Due to its pharmaceutical application, an extensive pharmacokinetic database exists in humans. Mathematical diffusion models allow for calculation of lindane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35c84e18e4e9ebf31110ac75532e86e
https://doi.org/10.1016/j.toxlet.2016.01.008
https://doi.org/10.1016/j.toxlet.2016.01.008
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 167(2)
Biotransformation rates extrapolated from in vitro data are used increasingly in human physiologically based pharmacokinetic (PBPK) models. This practice requires use of scaling factors, including microsomal content (mg of microsomal protein/g liver,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5ea8b94852eea5417ef3ffb83e27c3
https://pubmed.ncbi.nlm.nih.gov/30252107
https://pubmed.ncbi.nlm.nih.gov/30252107
Publikováno v:
Journal of Applied Toxicology. 36:1095-1111
As a result of its presence in water as a volatile disinfection byproduct, bromodichloromethane (BDCM), which is mutagenic, poses a potential health risk from exposure via oral, dermal and inhalation routes. We developed a refined human physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e7983a1c380876cecb9607f159783c
https://doi.org/10.1002/jat.3269
https://doi.org/10.1002/jat.3269
Autor:
Stig Regli, Michael S. Elovitz, Jimmy Chen, Rex A. Pegram, T.J. Pepping, Michael J. Messner, Susan D. Richardson, Frank J. Letkiewicz, J. Michael Wright
Publikováno v:
Environmental Science & Technology. 49:13094-13102
Public water systems are increasingly facing higher bromide levels in their source waters from anthropogenic contamination through coal-fired power plants, conventional oil and gas extraction, textile mills, and hydraulic fracturing. Climate change i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46dc6f14da78bf2f011f3e59b59460a5
https://doi.org/10.1021/acs.est.5b03547
https://doi.org/10.1021/acs.est.5b03547
Autor:
Marina V. Evans, William R. Mundy, Timothy J. Shafer, Chris R. Eklund, Andrew F.M. Johnstone, Rex A. Pegram, Cina M. Mack, Edward L. Croom
Publikováno v:
Toxicology and Applied Pharmacology. 283:9-19
Approaches for extrapolating in vitro toxicity testing results for prediction of human in vivo outcomes are needed. The purpose of this case study was to employ in vitro toxicokinetics and PBPK modeling to perform in vitro to in vivo extrapolation (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ca7de5e3a45cbab56797d0cf5bd77a
https://doi.org/10.1016/j.taap.2014.11.006
https://doi.org/10.1016/j.taap.2014.11.006
Autor:
Deborah S. Best, Randy A. Harrison, Susan R. Bielmeier, Jerome M. Goldman, Rex A. Pegram, Ashley S. Murr, Michael G. Narotsky
Publikováno v:
Toxicology in Vitro. 21:919-928
Bromodichloromethane (BDCM), a drinking water disinfection by-product, causes pregnancy loss, i.e. full-litter resorption, in F344 rats when treated during the luteinizing hormone (LH)-dependent period. This effect is associated with reduced maternal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d34dfe5b0e9f1571d0a258b39932516
https://doi.org/10.1016/j.tiv.2007.01.017
https://doi.org/10.1016/j.tiv.2007.01.017
Autor:
Martin Case, Benjamin C. Blount, John L. Valentine, Teresa L. Leavens, Rex A. Pegram, Michael C. Madden, Sarah H. Warren, Nancy M. Hanley, David M. DeMarini, Lalith K. Silva
Publikováno v:
Toxicological Sciences. 99:432-445
Exposure to bromodichloromethane (BDCM), one of the most prevalent disinfection byproducts in drinking water, can occur via ingestion of water and by dermal absorption and inhalation during activities such as bathing and showering. The objectives of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3360f7d3d70881adafc3bc0ce0283145
https://doi.org/10.1093/toxsci/kfm190
https://doi.org/10.1093/toxsci/kfm190