Výsledky vyhledávání

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

Autor: Andrew Clear, Rewas Fatah, Claude Chelala, Jennifer Watt, John G. Gribben, Abasi Ene–Obong, Hemant M. Kocher, Jun Wang, John Riches, John Marshall, Jo-Anne Chin Aleong, Alan G. Ramsay

Publikováno v: Gastroenterology. 145:1121-1132

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic microenvironment that contains many different immune cells. Activated pancreatic stellate cells (PSCs) contribute to the desmoplasia. We investigated whether distinc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423ee7bfff4b5c37ee756d0b607ba7ed
https://doi.org/10.1053/j.gastro.2013.07.025

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Generation of neoantigenic epitopes after posttranslational modification of type II collagen by factors present within the inflamed joint

Autor: Rewas Fatah, David Perrett, Ahuva Nissim, Paul G. Winyard, Gabriel S. Panayi, Yuti Chernajovsky, Valerie Corrigall

Publikováno v: Arthritis & Rheumatism. 52:3829-3838

Objective Collagen-induced arthritis is a commonly accepted model of rheumatoid arthritis (RA). However, it has been difficult to substantiate the involvement of autoimmunity to type II collagen (CII) in the pathogenesis of RA. The aim of this invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cf6d3a427f30c18ce1fef032bc3f05
https://doi.org/10.1002/art.21479

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Effects of APC De-targeting and GAr modification on the duration of luciferase expression from plasmid DNA delivered to skeletal muscle

Autor: Drew Hannaman, Rewas Fatah, David Gould, Ying Wu, Maria C. Subang, Yuti Chernajovsky, Jason Rice, Claire F. Evans

Publikováno v: Current Gene Therapy

Immune responses to expressed foreign transgenes continue to hamper progress of gene therapy development. Translated foreign proteins with intracellular location are generally less accessible to the immune system, nevertheless they can be presented t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc12f74ad59e2de32513c9d0b4d5da71
https://pubmed.ncbi.nlm.nih.gov/25545919

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Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β

Publikováno v: Expert opinion on drug delivery. 11(1)

Targeting cytokines to sites of disease has clear advantages because it increases their therapeutic index. We designed fusion proteins of the latent-associated peptide (LAP) derived from TGF-β with various cytokines via a matrix metalloproteinase (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6129e5be2be84478d176a51bc100d62f
https://pubmed.ncbi.nlm.nih.gov/24073618

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T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production

Autor: Fabienne McClanahan, Sameena Iqbal, John Riches, Jeff K. Davies, Rewas Fatah, Samir G. Agrawal, Alan G. Ramsay, John G. Gribben

Publikováno v: Blood. 121(9)

T-cell exhaustion, originally described in chronic viral infections, was recently reported in solid and hematologic cancers. It is not defined whether exhaustion contributes to T-cell dysfunction observed in chronic lymphocytic leukemia (CLL). We inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e33a87d1cb9134965ded60df7806a62
https://pubmed.ncbi.nlm.nih.gov/23449612

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Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer

Autor: John G. Gribben, Alan G. Ramsay, Rewas Fatah, Andrew Clear

Publikováno v: Blood. 120(7)

Cancer immune evasion is an emerging hallmark of disease progression. We have demonstrated previously that impaired actin polymerization at the T-cell immunologic synapse is a global immune dysfunction in chronic lymphocytic leukemia (CLL). Direct co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3823a434050c27af31538db0a7510545
https://pubmed.ncbi.nlm.nih.gov/22547582

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Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy

Autor: T. Andrew Lister, John G. Gribben, Finlay MacDougall, Janet Matthews, Andrew Clear, Maria Calaminici, Abigail M. Lee, Gavin Kelly, Alan G. Ramsay, Rewas Fatah

An important hallmark of cancer progression is the ability of tumor cells to evade immune recognition. Understanding the relationship between neoplastic cells and the immune microenvironment should facilitate the design of improved immunotherapies. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6633360e43df2e2f80cf21a36840ee14
https://europepmc.org/articles/PMC2780306/

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Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts

Autor: T. Andrew Lister, Alan G. Ramsay, Richard Mitter, Faridah Miraki-Moud, Abigail M. Lee, Rewas Fatah, John G. Gribben, David Taussig, Rifca Le Dieu

Publikováno v: Blood. 114(18)

Understanding how the immune system in patients with cancer interacts with malignant cells is critical for the development of successful immunotherapeutic strategies. We studied peripheral blood from newly diagnosed patients with acute myeloid leukem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8482a227d5ff3c0fbc14617c0b35e73
https://pubmed.ncbi.nlm.nih.gov/19710498

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Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors

Autor: Rewas Fatah, Taher E. Taher, Rizgar A. Mageed, David Gould, Fulvio D'Acquisto, C Tulone

Publikováno v: Gene therapy. 15(13)

B-lymphocytes play a key role in the pathogenesis of many immune-mediated diseases, such as autoimmune and atopic diseases. Therefore, targeting B-lymphocytes provides a rationale for refining strategies to treat such diseases for long-term clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863a83cc4a7387f9f5a558fedd6e25c1
https://pubmed.ncbi.nlm.nih.gov/18356817

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The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells

Autor: Thorsten Hagemann, Rewas Fatah, Ayse Ayhan, David Gould, Richard G. Thompson, Hagen Kulbe, Julia L. Wilson, Frances R. Balkwill, Stephen D. Robinson

Publikováno v: Cancer research. 67(2)

Constitutive expression of the inflammatory cytokine tumor necrosis factor-α (TNF-α) is characteristic of malignant ovarian surface epithelium. We investigated the hypothesis that this autocrine action of TNF-α generates and sustains a network of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4349ee2c3b3311af2b3532da66fa3474
https://pubmed.ncbi.nlm.nih.gov/17234767

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