Developmental changes in electrophysiological characteristics of human-induced pluripotent stem cell–derived cardiomyocytes

Autor: Ofer Binah, Inna Grijnevitch, Revital Schick, Amir Weissman, Meital Ben-Ari, Michael R. Rosen, Ronen Ben Jehuda, Irina Reiter, Omri Barak, Amit Raveh, Shulamit Naor, Naama Zeevi-Levin

Publikováno v: Heart Rhythm. 13:2379-2387

Background Previous studies proposed that throughout differentiation of human induced Pluripotent Stem Cell–derived cardiomyocytes (iPSC-CMs), only 3 types of action potentials (APs) exist: nodal-, atrial-, and ventricular-like. Objectives To inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396cf690cf2d616c7f337544e8060e6a
https://doi.org/10.1016/j.hrthm.2016.08.045

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy v1

Autor: Revital Schick

Aims: Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. Despite extensive research, the pathologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bcefb5967c4f55c48817746cd59edca
https://doi.org/10.17504/protocols.io.tvien4e

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

Autor: Yuval Shemer, Lubna Willi, Michael Arad, Michael Gramlich, Ofer Binah, Mihaela Gherghiceanu, Alessandra Moretti, Dov Freimark, Ronen Ben Jehuda, Rita Shulman, Meital Ben-Ari, Luna Simona Pane, Binyamin Eisen, Tova Hallas, Gianluca Santamaria, Revital Schick, Agnes Szantai, Lucy N. Mekies, Ilaria My, Marta Murgia

Publikováno v: PLoS One
PLOS ONE
PLoS ONE
PLOS ONE 13(10), e0205719 (2018). doi:10.1371/journal.pone.0205719
PLoS ONE, Vol 13, Iss 10, p e0205719 (2018)

Aims Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. Despite extensive research, the pathologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3123d25edbfb721332acd04884d6e3c7
https://hdl.handle.net/21.11116/0000-0002-F13F-821.11116/0000-0002-F140-521.11116/0000-0002-F13D-A

Investigating the cardiac pathology of SCO2-mediated hypertrophic cardiomyopathy using patients induced pluripotent stem cell-derived cardiomyocytes

Autor: Binyamin Eisen, Yeshayahu Katz, Tova Hallas, Revital Schick, Avraham Lorber, Eugene Vlodavsky, Irina Reiter, Katrin Õunap, Yuval Shemer, Richard J. Rodenburg, Lucy N. Mekies, Shulamit Naor, Hanna Mandel, Ofer Binah, Mihaela Gherghiceanu, Sivan Eliyahu, Ronen Ben Jehuda

Publikováno v: Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine, 22, 913-925
Journal of Cellular and Molecular Medicine, 22, 2, pp. 913-925

Mutations in SCO2 are among the most common causes of COX deficiency, resulting in reduced mitochondrial oxidative ATP production capacity, often leading to hypertrophic cardiomyopathy (HCM). To date, none of the recent pertaining reports provide dee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6eb37b1aedaec124d315ad81e6917d
https://pubmed.ncbi.nlm.nih.gov/29193756

Human Embryonic and Induced Pluripotent Stem Cell–Derived Cardiomyocytes Exhibit Beat Rate Variability and Power-Law Behavior

Autor: Amir Weissman, Gideon Meiry, Lili Barad, Atara Novak, Joseph Itskovitz-Eldor, Revital Schick, Avraham Lorber, Michael R. Rosen, Ofer Binah, Stanislav Goldberg, Yael Mandel

Publikováno v: Circulation. 125:883-893

Background— The sinoatrial node is the main impulse-generating tissue in the heart. Atrioventricular conduction block and arrhythmias caused by sinoatrial node dysfunction are clinically important and generally treated with electronic pacemakers. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5aa3c5434ff87165f1d9e0a3ba9407
https://doi.org/10.1161/circulationaha.111.045146