Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Revital Levy"'
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-32 (2023)
Abstract Background Common diseases manifest differentially between patients, but the genetic origin of this variation remains unclear. To explore possible involvement of gene transcriptional-variation, we produce a DNA methylation-oriented, driver-g
Externí odkaz:
https://doaj.org/article/ef509bc1eb494990b9f0e8f6fed3f9a6
Autor:
Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka, Raymond Kaempfer
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-16 (2023)
Abstract Background The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interaction of costimulato
Externí odkaz:
https://doaj.org/article/72abed205b8b4743a7793760acc8aa32
Autor:
Martina Kunkl, Carola Amormino, Silvana Caristi, Valentina Tedeschi, Maria Teresa Fiorillo, Revital Levy, Andrey Popugailo, Raymond Kaempfer, Loretta Tuosto
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The inflammatory activity of staphylococcal enterotoxin B (SEB) relies on its capacity to trigger polyclonal T-cell activation by binding both T-cell receptor (TCR) and costimulatory receptor CD28 on T cells and MHC class II and B7 molecules on antig
Externí odkaz:
https://doaj.org/article/e9839b2de1114e4c8aeff04c20fb8389
Publikováno v:
Toxins, Vol 5, Iss 9, Pp 1531-1542 (2013)
Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune respo
Externí odkaz:
https://doaj.org/article/54d5b2359ca14b6fad505df992d8f20a
Autor:
Dvir Aran, Monther Abu-Remaileh, Revital Levy, Nurit Meron, Gidon Toperoff, Yifat Edrei, Yehudit Bergman, Asaf Hellman
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005840 (2016)
Cancers often display gene expression profiles resembling those of undifferentiated cells. The mechanisms controlling these expression programs have yet to be identified. Exploring transcriptional enhancers throughout hematopoietic cell development a
Externí odkaz:
https://doaj.org/article/ae109088c83b4545a64ee35e843c0339
Autor:
Gila Arad, Revital Levy, Iris Nasie, Dalia Hillman, Ziv Rotfogel, Uri Barash, Emmanuelle Supper, Tomer Shpilka, Adi Minis, Raymond Kaempfer
Publikováno v:
PLoS Biology, Vol 13, Iss 8, p e1002237 (2015)
Externí odkaz:
https://doaj.org/article/a3404a90428d4020b2cf09124f5e6d82
Autor:
Gila Arad, Revital Levy, Iris Nasie, Dalia Hillman, Ziv Rotfogel, Uri Barash, Emmanuelle Supper, Tomer Shpilka, Adi Minis, Raymond Kaempfer
Publikováno v:
PLoS Biology, Vol 9, Iss 9, p e1001149 (2011)
Bacterial superantigens, a diverse family of toxins, induce an inflammatory cytokine storm that can lead to lethal shock. CD28 is a homodimer expressed on T cells that functions as the principal costimulatory ligand in the immune response through an
Externí odkaz:
https://doaj.org/article/2c5298f26ef74f0fa8ebd46414d22eec
Cancers arise when particular disease-driving genes adopt abnormal functions, but analyses of coding and regulatory sequences leave many of these abnormalities unexplained. We developed a strategy to explore alternations in the regulatory effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9f3fca59bd758ce9f7a4b3345ab4e02
https://doi.org/10.1101/2021.03.02.433521
https://doi.org/10.1101/2021.03.02.433521
Autor:
Uzorchukwu Michael Ogu, Nur Hidayah Jamar, Douglas Law, Ziv Rotfogel, Hind Chakchak, D. T. Sakhare, Aziz Chaouch, Mahanem Mat Noor, Deepti Joshi, Ahmad Azfaralariff, Shazrul Fazry, Izabel Luzia Miranda, Sujit Kumar Shah, Man Singh, Hamid Zineddine, B. D. Kalyankar, Sameer A. Karpe, Amarachi Maduka, Marisa Alves Nogueira Diaz, Siti Aisyah Sanusi, Charity Ebere Anarado, Benjamin Chimezie Izuagbachukwu, Chinyelu Ijeamaka Egwuatu, Chigozie John Onyinye Anarado, Herryawan Ryadi Eziwar Dyari, Geeta Verma, Nik Marzuki Sidik, Gaspar Diaz-Muñoz, S. Sophie Beulah, Iris Nasie, Sujeet Kumar Chatterjee, Babul Airianah Othman, Valentine Ifenna Onwukeme, Yi Chieh Lim, Ajaya Bhattarai, Muhammad Akram Mohd Noordin, Madhup Chandra, Revital Levy, Suélen K. Sartori, Azwan Mat Lazim, K. Muthukumaran, Gila Arad, K.M. Sachin, Raymond Kaempfer, Yew Hoong Cheah, Dalia Hillman, S. P. Vartale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d31d2ad07a67f056f26a3a252bc6c2d
https://doi.org/10.9734/bpi/cpcs/v1
https://doi.org/10.9734/bpi/cpcs/v1
Autor:
Raymond, Kaempfer, Andrey, Popugailo, Revital, Levy, Gila, Arad, Dalia, Hillman, Ziv, Rotfogel
Publikováno v:
Receptorsclinical investigation. 4(1)
Formation of the costimulatory axis between the B7-2 and CD28 coreceptors is critical for T-cell activation. Superantigens, Gram-positive bacterial virulence factors, cause toxic shock and sepsis by hyperinducing inflammatory cytokines. We report a n