Zobrazeno 1 - 10
of 432
pro vyhledávání: '"Reverse phase protein array"'
Autor:
Matthew B. Friese, Taranjit S. Gujral, Arvind Palanisamy, Brittany Hemmer, Deborah J. Culley, Gregory Crosby
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionThe development and maintenance of neural circuits is highly sensitive to neural activity. General anesthetics have profound effects on neural activity and, as such, there is concern that these agents may alter cellular integrity and inte
Externí odkaz:
https://doaj.org/article/1ec1488a3491450195bd534c1525c94b
Autor:
John C. Dawson, Alison Munro, Kenneth Macleod, Morwenna Muir, Paul Timpson, Robert J. Williams, Margaret Frame, Valerie G. Brunton, Neil O. Carragher
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1072-1090 (2022)
A more comprehensive understanding of how cells respond to drug intervention, the likely immediate signalling responses and how resistance may develop within different microenvironments will help inform treatment regimes. The nonreceptor tyrosine kin
Externí odkaz:
https://doaj.org/article/fab8f61f00ef4132b7b597f9dca6a022
Akademický článek
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Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsuccessful, suggesting
Externí odkaz:
https://doaj.org/article/a9fd937ff1a74cbaa05f6586c5d7dfb3
Publikováno v:
BMC Medical Genomics, Vol 12, Iss S5, Pp 1-14 (2019)
Abstract Background The analysis of integrated multi-omics data enables the identification of disease-related biomarkers that cannot be identified from a single omics profile. Although protein-level data reflects the cellular status of cancer tissue
Externí odkaz:
https://doaj.org/article/dd9b636971274e458e271cb44c128bcf
Autor:
Md. Mahiuddin Ahmed, Andrew J. Carrel, Yasmin Cruz Del Angel, Jessica Carlsen, Ajay X. Thomas, Marco I. González, Katheleen J. Gardiner, Amy Brooks-Kayal
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Epilepsy is characterized by recurrent, spontaneous seizures and is a major contributor to the global burden of neurological disease. Although epilepsy can result from a variety of brain insults, in many cases the cause is unknown and, in a significa
Externí odkaz:
https://doaj.org/article/2dd34466bf12465bb4794d3c67504428
Akademický článek
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Akademický článek
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Autor:
Min Jin Ha, Sayantan Banerjee, Rehan Akbani, Han Liang, Gordon B. Mills, Kim-Anh Do, Veerabhadran Baladandayuthapani
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Personalized (patient-specific) approaches have recently emerged with a precision medicine paradigm that acknowledges the fact that molecular pathway structures and activity might be considerably different within and across tumors. The funct
Externí odkaz:
https://doaj.org/article/43e7c4bc16ff4b8082b5fe42d8213ff3
Autor:
Simona di Martino, Gabriele De Luca, Ludovica Grassi, Giulia Federici, Romina Alfonsi, Michele Signore, Antonio Addario, Laura De Salvo, Federica Francescangeli, Massimo Sanchez, Valentina Tirelli, Giovanni Muto, Isabella Sperduti, Steno Sentinelli, Manuela Costantini, Luca Pasquini, Michele Milella, Mustapha Haoui, Giuseppe Simone, Michele Gallucci, Ruggero De Maria, Désirée Bonci
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-18 (2018)
Abstract Background Clear cell RCC (ccRCC) accounts for approximately 75% of the renal cancer cases. Surgery treatment seems to be the best efficacious approach for the majority of patients. However, a consistent fraction (30%) of cases progress afte
Externí odkaz:
https://doaj.org/article/341e781e588f47e2b9b33edfae052a32