Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study.

Autor: Zhanghua Chen, Mark A Pereira, Mark Seielstad, Woon-Puay Koh, E Shyong Tai, Yik-Ying Teo, Jianjun Liu, Chris Hsu, Renwei Wang, Andrew O Odegaard, Bharat Thyagarajan, Revati Koratkar, Jian-Min Yuan, Myron D Gross, Daniel O Stram

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87762 (2014)

Genome-wide association studies (GWAS) have identified genetic factors in type 2 diabetes (T2D), mostly among individuals of European ancestry. We tested whether previously identified T2D-associated single nucleotide polymorphisms (SNPs) replicate an

Externí odkaz: https://doaj.org/article/e650ba294ada4a2682ee1c425b5c012c

Diversity in secreted PLA2-IIA activity among inbred mouse strains that are resistant or susceptible to ApcMin/+ tumorigenesis

Autor: Linda D. Siracusa, Revati Koratkar, Karen A. Silverman, Arthur M. Buchberg, Rhonda Walters, Melina Macphee-Pellini, Vincent E. Sollars, Steven A. Farber, Marina Markova, Juan P. Palazzo

Publikováno v: Oncogene. 24:6450-6458

The secreted phospholipase A2 type IIA (Pla2g2a) gene was previously identified as a modifier of intestinal adenoma multiplicity in Apc Min/+ mice. To determine if intestinal secreted phospholipase A2 (sPLA2) activity was also attenuated in susceptib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0c36156494e042ec0fbbf6e196e803
https://doi.org/10.1038/sj.onc.1208791

The Cohesin SMC3 Is a Target the for β-Catenin/TCF4 Transactivation Pathway

Autor: Giancarlo Ghiselli, Revati Koratkar, Christine E. Munnery, Nefeteria Coffee, Linda D. Siracusa

Publikováno v: Journal of Biological Chemistry. 278:20259-20267

The structural maintenance of chromosome protein SMC3 is a component of the cohesin complex that mediates sister chromatid cohesion and segregation in prokaryotes and eukaryotes. It is also present extracellularly in the form of a chondroitin sulfate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb7a65937e9071634b080215dc6f192
https://doi.org/10.1074/jbc.m209511200

Identification of the Modifier of Min 2 (Mom2) Locus, a New Mutation That Influences Apc-Induced Intestinal Neoplasia

Autor: Linda D. Siracusa, Karen A. Silverman, Revati Koratkar, Arthur M. Buchberg

Publikováno v: Genome Research. 12:88-97

Min (Multiple intestinalneoplasia) mice carry a dominant mutation in the adenomatous polyposis coli (Apc) gene and develop multiple adenomas throughout their intestinal tract (Moser et al. 1990; Su et al. 1992). Polyp multiplicity in Min mice is grea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021b801b1cb660f9b3817804b55fded6
https://doi.org/10.1101/gr.206002

Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study

Autor: Daniel O. Stram, Jianjun Liu, Chris Hsu, Yik Ying Teo, Myron D. Gross, Woon-Puay Koh, Mark Seielstad, Renwei Wang, Bharat Thyagarajan, Revati Koratkar, Mark A. Pereira, E. Shyong Tai, Zhanghua Chen, Andrew O. Odegaard, Jian-Min Yuan

Publikováno v: PLoS ONE
Chen, Z; Pereira, MA; Seielstad, M; Koh, WP; Tai, ES; Teo, YY; et al.(2014). Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: The Singapore Chinese health study. PLoS ONE, 9(2). doi: 10.1371/journal.pone.0087762. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8dr6m6p7
PloS one, vol 9, iss 2
PLoS ONE, Vol 9, Iss 2, p e87762 (2014)

Author(s): Chen, Zhanghua; Pereira, Mark A; Seielstad, Mark; Koh, Woon-Puay; Tai, E Shyong; Teo, Yik-Ying; Liu, Jianjun; Hsu, Chris; Wang, Renwei; Odegaard, Andrew O; Thyagarajan, Bharat; Koratkar, Revati; Yuan, Jian-Min; Gross, Myron D; Stram, Danie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74bf30d569df7793b1a8bd1b94317b3
https://pubmed.ncbi.nlm.nih.gov/24520337