Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Reuven Wiener"'
Autor:
Alexander Rouvinski, Ahuva Friedman, Saveliy Kirillov, Jordan Hannink Attal, Sujata Kumari, Jamal Fahoum, Reuven Wiener, Sophie Magen, Yevgeni Plotkin, Daniel Chemtob, Herve Bercovier
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The humoral response after the fourth dose of a mRNA vaccine against COVID-19 has not been adequately described in elderly recipients, particularly those not exposed previously to SARS-CoV-2. Serum anti-RBD IgG levels (Abbott SARS-CoV-2 IgG
Externí odkaz:
https://doaj.org/article/69404afee59e494c9a707e00d24eb698
Autor:
Tamar Szoke, Omer Goldberger, Nitsan Albocher-Kedem, Meshi Barsheshet, Nili Dezorella, Anat Nussbaum-Shochat, Reuven Wiener, Maya Schuldiner, Orna Amster-Choder
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113393- (2023)
Summary: TmaR, the only known pole-localizer protein in Escherichia coli, was shown to cluster at the cell poles and control localization and activity of the major sugar regulator in a tyrosine phosphorylation-dependent manner. Here, we show that Tma
Externí odkaz:
https://doaj.org/article/4c37df5d4d0e4875bee1cc7c8f46a774
Autor:
Miri Stolovich-Rain, Sujata Kumari, Ahuva Friedman, Saveliy Kirillov, Yakov Socol, Maria Billan, Ritesh Ranjan Pal, Kathakali Das, Peretz Golding, Esther Oiknine-Djian, Salim Sirhan, Michal Bejerano Sagie, Einav Cohen-Kfir, Naama Gold, Jamal Fahoum, Manoj Kumar, Maya Elgrably-Weiss, Bing Zhou, Miriam Ravins, Yair E. Gatt, Saurabh Bhattacharya, Orly Zelig, Reuven Wiener, Dana G. Wolf, Hila Elinav, Jacob Strahilevitz, Dan Padawer, Leah Baraz, Alexander Rouvinski
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Intramuscularly administered vaccines stimulate robust serum neutralizing antibodies, yet they are often less competent in eliciting sustainable “sterilizing immunity” at the mucosal level. Our study uncovers a strong temporary neutralizing mucos
Externí odkaz:
https://doaj.org/article/72713589dd6d4da3b78f31258a7786b8
Autor:
Manoj Kumar, Prasanth Padala, Jamal Fahoum, Fouad Hassouna, Tomer Tsaban, Guy Zoltsman, Sayanika Banerjee, Einav Cohen-Kfir, Moshe Dessau, Rina Rosenzweig, Michail N. Isupov, Ora Schueler-Furman, Reuven Wiener
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Ufmylation is a well-established ubiquitin-like protein modification, but its mechanism is largely unclear. Here, the authors present a crystal structure of the ufmylation-specific E1-E2 complex, revealing differences to the ubiquitination machinery
Externí odkaz:
https://doaj.org/article/92a7bec4aca04541b5ce9c87607504cd
Autor:
Adi Amar-Schwartz, Vered Ben Hur, Amina Jbara, Yuval Cohen, Georgina D Barnabas, Eliran Arbib, Zahava Siegfried, Bayan Mashahreh, Fouad Hassouna, Asaf Shilo, Mohammad Abu-Odeh, Michael Berger, Reuven Wiener, Rami Aqeilan, Tamar Geiger, Rotem Karni
Publikováno v:
eLife, Vol 11 (2022)
The mTORC1 substrate, S6 Kinase 1 (S6K1), is involved in the regulation of cell growth, ribosome biogenesis, glucose homeostasis, and adipogenesis. Accumulating evidence has suggested a role for mTORC1 signaling in the DNA damage response. This is mo
Externí odkaz:
https://doaj.org/article/415f0119bfe2430898b264371e2f1a67
Autor:
Pallabi Basu, Maya Elgrably-Weiss, Fouad Hassouna, Manoj Kumar, Reuven Wiener, Shoshy Altuvia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
RelA stimulates RyhB small RNA–target mRNA interaction by promoting assembly of Hfq monomers into hexamers. Here the authors show that RelA-mediated Hfq hexamerization requires an initial binding of RNA to Hfq monomers.
Externí odkaz:
https://doaj.org/article/e9c5197e01e44b3fab2266c9e1eaaceb
Publikováno v:
Cells, Vol 11, Iss 24, p 4109 (2022)
Ubiquitination is a critical type of post-translational modification in eukaryotic cells. It is involved in regulating nearly all cellular processes in the cytosol and nucleus. Mitochondria, known as the metabolism heart of the cell, are organelles t
Externí odkaz:
https://doaj.org/article/f4ad56d50a114c19b9fb45e9690a79b8
Autor:
Amjad Shhadeh, Johanna Galaski, Tamar Alon-Maimon, Jamal Fahoum, Reuven Wiener, Daniel J. Slade, Ofer Mandelboim, Gilad Bachrach
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Recent studies on the oral, anaerobic, gram-negative bacterium Fusobacterium nucleatum revealed its presence and involvement in colorectal, esophageal and breast cancer. We previously demonstrated that F. nucleatum binds and activates the human inhib
Externí odkaz:
https://doaj.org/article/ddc1f5e0805744c8aca90ddabdda3e78
Autor:
Prasanth Padala, Walaa Oweis, Bayan Mashahreh, Nadine Soudah, Einav Cohen-Kfir, Emily A. Todd, Christopher E. Berndsen, Reuven Wiener
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The modification of proteins by ubiquitin-fold modifier 1 (UFM1) is implicated in many human diseases. Prior to conjugation, UFM1 undergoes activation by its cognate activating enzyme, UBA5. UBA5 is a non-canonical E1 activating enzyme that
Externí odkaz:
https://doaj.org/article/ac087b7b55684d7abb3c727afb7179d7
Autor:
Walaa Oweis, Prasanth Padala, Fouad Hassouna, Einav Cohen-Kfir, Dalton R. Gibbs, Emily A. Todd, Christopher E. Berndsen, Reuven Wiener
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3113-3120 (2016)
Modification of proteins by ubiquitin or ubiquitin-like proteins (UBLs) is a critical cellular process implicated in a variety of cellular states and outcomes. A prerequisite for target protein modification by a UBL is the activation of the latter by
Externí odkaz:
https://doaj.org/article/366b31b886ba4b12a050a6bc4a4bcd7b