Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Reut Shalgi"'
Autor:
Katelyn M Sweeney, Sapanna Chantarawong, Edward M Barbieri, Greg Cajka, Matthew Liu, Lynn Spruce, Hossein Fazelinia, Bede Portz, Katie Copley, Tomer Lapidot, Lauren Duhamel, Phoebe Greenwald, Naseeb Saida, Reut Shalgi, James Shorter, Ophir Shalem
Publikováno v:
PLoS Genetics, Vol 20, Iss 2, p e1011138 (2024)
The presence of large protein inclusions is a hallmark of neurodegeneration, and yet the precise molecular factors that contribute to their formation remain poorly understood. Screens using aggregation-prone proteins have commonly relied on downstrea
Externí odkaz:
https://doaj.org/article/ff563c2f2e794dd693786fc7a6613821
Autor:
Kinneret Rozales, Amal Younis, Naseeb Saida, Anatoly Meller, Hodaya Goldman, Lior Kellerman, Ronit Heinrich, Shai Berlin, Reut Shalgi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here, using quantitative screens in human cells, the authors reveal distinct effects of naturally-occurring DNAJ chaperone isoforms on pathological aggregation of the Huntington’s disease-associated HTT-polyQ and the ALS-related mutant FUS.
Externí odkaz:
https://doaj.org/article/6977f04c4c43467a8304b47091e32030
Autor:
Reem Jada, Liron Zag, Veronika Borisov, Nina S. Levy, Shai Netser, Renad Jabarin, Shlomo Wagner, Kinneret Schragenheim-Rozales, Reut Shalgi, Andrew P. Levy
Publikováno v:
International Journal of Hyperthermia, Vol 38, Iss 1, Pp 1495-1501 (2021)
Objectives Mutations in the human IQSEC2 gene are associated with drug-resistant epilepsy and severe behavioral dysfunction. We have focused on understanding one human IQSEC2 missense mutation (A350V) for which we have created a corresponding A350V I
Externí odkaz:
https://doaj.org/article/84ce4ee8e3184e6091fc234735250169
Publikováno v:
iScience, Vol 19, Iss , Pp 204-213 (2019)
Summary: The endoplasmic reticulum (ER) stress response, also known as the unfolded protein response (UPR), is a complex cellular response to ER protein misfolding that involves transcriptional regulatory branches and a PERK-mediated translational re
Externí odkaz:
https://doaj.org/article/00abfc5390584ab19734ab8c213ffc88
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-7 (2018)
Abstract Background Recent studies have described a widespread induction of transcriptional readthrough as a consequence of various stress conditions in mammalian cells. This novel phenomenon, initially identified from analysis of RNA-seq data, sugge
Externí odkaz:
https://doaj.org/article/095d3024c6f545b9909e0d55b7bfe327
Publikováno v:
Human Genomics, Vol 12, Iss 1, Pp 1-4 (2018)
Abstract Naturally occurring stress-induced transcriptional readthrough is a recently discovered phenomenon, in which stress conditions lead to dramatic induction of long transcripts as a result of transcription termination failure. In 2015, we repor
Externí odkaz:
https://doaj.org/article/893231a7235f4b509ab8ce679bfa7c5c
Autor:
Eli J. Rogers, Reem Jada, Kinneret Schragenheim-Rozales, Megha Sah, Marisol Cortes, Matthew Florence, Nina S. Levy, Rachel Moss, Randall S. Walikonis, Raz Palty, Reut Shalgi, Daniela Lichtman, Alexandra Kavushansky, Nashaat Z. Gerges, Itamar Kahn, George K. E. Umanah, Andrew P. Levy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular pathophysiology of this mutation with the goal of developing targets for drug intervention. We
Externí odkaz:
https://doaj.org/article/14ef286995ec4aa7b07fafd45f233f65
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1362-1370 (2014)
During heat shock and other proteotoxic stresses, cells regulate multiple steps in gene expression in order to globally repress protein synthesis and selectively upregulate stress response proteins. Splicing of several mRNAs is known to be inhibited
Externí odkaz:
https://doaj.org/article/0eea6cd1968445ec8e84700b60e4a162
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 7, p e131 (2007)
microRNAs (miRs) are small RNAs that regulate gene expression at the posttranscriptional level. It is anticipated that, in combination with transcription factors (TFs), they span a regulatory network that controls thousands of mammalian genes. Here w
Externí odkaz:
https://doaj.org/article/4bf60764b98b4637b02ac1f5d2cfb7f6
Autor:
Kinneret Schragenheim-Rozales, Nina S. Levy, Shai Netser, Reut Shalgi, Renad Jabarin, Reem Jada, Veronika Borisov, Liron Zag, Shlomo Wagner, Andrew P. Levy
Publikováno v:
International Journal of Hyperthermia, Vol 38, Iss 1, Pp 1495-1501 (2021)
Objectives Mutations in the human IQSEC2 gene are associated with drug-resistant epilepsy and severe behavioral dysfunction. We have focused on understanding one human IQSEC2 missense mutation (A350V) for which we have created a corresponding A350V I