Výsledky vyhledávání - "Reut Friedrich"

From spike to graph—A complete automated single-spike analysis

Autor: Reut Friedrich, Uri Ashery

Publikováno v: Journal of Neuroscience Methods. 193:271-280

Amperometry is a commonly used technique for detecting the kinetics of single-vesicle exocytosis with excellent temporal and spatial resolution. However, different methods of analyzing the amperometric signals can produce conflicting conclusions. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bc21d9cf6a50edf010a5a37b9da31f
https://doi.org/10.1016/j.jneumeth.2010.09.004

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Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cells

Autor: Rachel Nachman, Jens Rettig, Uri Ashery, Ilana Lotan, Dodo Chikvashvili, Reut Friedrich, Lori Feinshreiber, Anton Sheinin, Ofer Yizhar, Dafna Singer-Lahat, Ulf Matti

Publikováno v: Journal of Cell Science. 123:1940-1947

Regulation of exocytosis by voltage-gated K+ channels has classically been viewed as inhibition mediated by K+ fluxes. We recently identified a new role for Kv2.1 in facilitating vesicle release from neuroendocrine cells, which is independent of K+ f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a55e836a83222db6c098d2dcc22b8bb
https://doi.org/10.1242/jcs.063719

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DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties

Autor: Alexander J. Groffen, Matthijs Verhage, Uri Ashery, Elisabeth C. Brian, Reut Friedrich

Publikováno v: Journal of Neurochemistry. 97:818-833

Elevation of the intracellular calcium concentration ([Ca2+]i) to levels below 1 µm alters synaptic transmission and induces short-term plasticity. To identify calcium sensors involved in this signalling, we investigated soluble C2 domain-containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82fc6052cda0e289dd5c5f0d7fa717f8
https://doi.org/10.1111/j.1471-4159.2006.03755.x

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DOC2B, C2 domains, and calcium: A tale of intricate interactions

Autor: Uri Ashery, Adva Yeheskel, Reut Friedrich

Publikováno v: Molecular neurobiology. 41(1)

Ca(+2)-dependent exocytosis involves vesicle docking, priming, fusion, and recycling. This process is performed and regulated by a vast number of synaptic proteins and depends on proper protein-protein and protein-lipid interactions. Double C2 domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d1ad14fd55e0638018853ee6866e68
https://pubmed.ncbi.nlm.nih.gov/20052564

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DOC2B acts as a calcium switch and enhances vesicle fusion

Autor: Emma Connell, Uri Ashery, Orit Gutman, Yoav I. Henis, Reut Friedrich, Alexander J. Groffen, J. R. T. van Weering, Bazbek Davletov

Publikováno v: Friedrich, R, Groffen, A J A, Connell, E, van Weering, J R T, Gotman, O, Henis, Y I, Davletov, B & Ashery, U 2008, ' DOC2B acts as a calcium switch and enhances vesicle fusion ', The Journal of Neuroscience, vol. 28, pp. 6794-6806 . https://doi.org/10.1523/JNEUROSCI.0538-08.2008
Friedrich, R, Groffen, A J A, Connell, E, van Weering, J R T, Gotman, O, Henis, Y I, Davletov, B & Ashery, U 2008, ' DOC2B acts as a calcium switch and enhances vesicle fusion ', Journal of Neuroscience, vol. 28, pp. 6794-6806 . https://doi.org/10.1523/JNEUROSCI.0538-08.2008
Journal of Neuroscience, 28, 6794-6806. Society for Neuroscience
The Journal of Neuroscience, 28, 6794-6806. Society for Neuroscience

Calcium-dependent exocytosis is regulated by a vast number of proteins. DOC2B is a synaptic protein that translocates to the plasma membrane (PM) after small elevations in intracellular calcium concentration. The aim of this study was to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09733616d23d413f94b1f8692dfe5e23
https://research.vu.nl/en/publications/3418371a-fd54-4082-bd4d-73c48a8e0079

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K(+) Channel Facilitation of Exocytosis by Dynamic Interaction with Syntaxin

Autor: Uri Ashery, Ilana Lotan, Reut Friedrich, Dodo Chikvashvili, Dafna Singer-Lahat, Dafna Greitzer, Lori Feinshreiber, Anton Sheinin, Sharon Tsuk, Edwin S. Levitan, Morris Benveniste

Kv channels inhibit release indirectly by hyperpolarizing membrane potential, but the significance of Kv channel interaction with the secretory apparatus is not known. The Kv2.1 channel is commonly expressed in the soma and dendrites of neurons, wher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6840d044ed3fc8d0873dee503e0f0f
https://europepmc.org/articles/PMC6673747/

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DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties

Autor: Alexander J A, Groffen, Reut, Friedrich, Elisabeth C, Brian, Uri, Ashery, Matthijs, Verhage

Publikováno v: Journal of neurochemistry. 97(3)

Elevation of the intracellular calcium concentration ([Ca2+]i) to levels below 1 microm alters synaptic transmission and induces short-term plasticity. To identify calcium sensors involved in this signalling, we investigated soluble C2 domain-contain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5091857aa75a72bb2703ddcd6c20ef00
https://pubmed.ncbi.nlm.nih.gov/16515538

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