Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Autor: Aschenbrenner, A.C. Mouktaroudi, M. Krämer, B. Oestreich, M. Antonakos, N. Nuesch-Germano, M. Gkizeli, K. Bonaguro, L. Reusch, N. Baßler, K. Saridaki, M. Knoll, R. Pecht, T. Kapellos, T.S. Doulou, S. Kröger, C. Herbert, M. Holsten, L. Horne, A. Gemünd, I.D. Rovina, N. Agrawal, S. Dahm, K. van Uelft, M. Drews, A. Lenkeit, L. Bruse, N. Gerretsen, J. Gierlich, J. Becker, M. Händler, K. Kraut, M. Theis, H. Mengiste, S. De Domenico, E. Schulte-Schrepping, J. Seep, L. Raabe, J. Hoffmeister, C. ToVinh, M. Keitel, V. Rieke, G. Talevi, V. Skowasch, D. Aziz, N.A. Pickkers, P. van de Veerdonk, F.L. Netea, M.G. Schultze, J.L. Kox, M. Breteler, M.M.B. Nattermann, J. Koutsoukou, A. Giamarellos-Bourboulis, E.J. Ulas, T. German COVID-19 Omics Initiative (DeCOI)

BACKGROUND: The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::107b592271ccb709768f451d752d0897
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3076244

Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.

Autor: Baßler K; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Fujii W; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Kapellos TS; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Dudkin E; Computational Life Sciences, Life & Medical Sciences (LIMES) Institute, University of Bonn, Neuherberg, Germany., Reusch N; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Horne A; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Reiz B; Comma Soft AG, Bonn, Germany., Luecken MD; Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany., Osei-Sarpong C; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany., Warnat-Herresthal S; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Bonaguro L; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Schulte-Schrepping J; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Wagner A; Department of electrical engineering and computer science, University of California, Berkeley, CA, United States.; Center for computational biology, University of California, Berkeley, CA, United States., Günther P; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany., Pizarro C; Department of Internal Medicine II, University Hospital Bonn, Section of Pneumology, Bonn, Germany., Schreiber T; Department of Internal Medicine II, University Hospital Bonn, Section of Pneumology, Bonn, Germany., Knoll R; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Prevention, Aging & Systems Immunology, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany., Holsten L; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Kröger C; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; Prevention, Aging & Systems Immunology, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany., De Domenico E; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Becker M; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Händler K; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Wohnhaas CT; Computational Biology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany., Baumgartner F; Comma Soft AG, Bonn, Germany., Köhler M; Comma Soft AG, Bonn, Germany., Theis H; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Kraut M; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Wadsworth MH 2nd; Institute for Medical Engineering & Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.; Broad Institute of MIT and Harvard; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States., Hughes TK; Institute of Structural Biology, University Hospital, University of Bonn, Bonn, Germany., Ferreira HJ; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany., Hinkley E; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Kaltheuner IH; Institute of Structural Biology, University Hospital, University of Bonn, Bonn, Germany., Geyer M; Biochemistry & Cell Biology of Lipids, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Thiele C; University Clinics for Radiology, University Hospital Bonn, Bonn, Germany., Shalek AK; Institute for Medical Engineering & Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States.; Broad Institute of MIT and Harvard; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States., Feißt A; University Clinics for Radiology, University Hospital Bonn, Bonn, Germany., Thomas D; University Clinics for Radiology, University Hospital Bonn, Bonn, Germany., Dickten H; Comma Soft AG, Bonn, Germany., Beyer M; Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Baum P; Translational Medicine & Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany., Yosef N; Department of electrical engineering and computer science, University of California, Berkeley, CA, United States.; Center for computational biology, University of California, Berkeley, CA, United States.; Chan-Zuckerberg Biohub, San Francisco, CA, United States.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States., Aschenbrenner AC; Prevention, Aging & Systems Immunology, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States.; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, Netherlands., Ulas T; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Hasenauer J; Computational Life Sciences, Life & Medical Sciences (LIMES) Institute, University of Bonn, Neuherberg, Germany.; Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany., Theis FJ; Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany, Department of Mathematics, Technical University of Munich, Munich, Germany., Skowasch D; Department of Internal Medicine II, University Hospital Bonn, Section of Pneumology, Bonn, Germany., Schultze JL; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn, Bonn, Germany.; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Jul 28; Vol. 13, pp. 917232. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022).

Cannabinoid receptor 2 is necessary to induce toll-like receptor-mediated microglial activation.

Autor: Reusch N; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), Bonn, Germany., Ravichandran KA; Institute for Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany., Olabiyi BF; Institute for Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany., Komorowska-Müller JA; Institute for Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany.; International Max Planck Research School for Brain and Behavior, University of Bonn, Bonn, Germany., Hansen JN; Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany., Ulas T; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), Bonn, Germany.; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases (DZNE), University of Bonn, Bonn, Germany., Beyer M; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases (DZNE), University of Bonn, Bonn, Germany.; Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Zimmer A; Institute for Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany., Schmöle AC; Institute for Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany.

Publikováno v: Glia [Glia] 2022 Jan; Vol. 70 (1), pp. 71-88. Date of Electronic Publication: 2021 Sep 09.

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.

Autor: Krämer B; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Knoll R; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Bonaguro L; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., ToVinh M; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Raabe J; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Astaburuaga-García R; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt- Universität zu Berlin, Institute of Pathology, Berlin, Germany; IRI Life Sciences & Institute of Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, Germany., Schulte-Schrepping J; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Kaiser KM; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Rieke GJ; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Bischoff J; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Monin MB; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Hoffmeister C; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Schlabe S; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany; German Center for Infection Research (DZIF), Germany., De Domenico E; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany., Reusch N; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Händler K; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany., Reynolds G; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Blüthgen N; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt- Universität zu Berlin, Institute of Pathology, Berlin, Germany; IRI Life Sciences & Institute of Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, Germany., Hack G; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Finnemann C; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Nischalke HD; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Strassburg CP; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Stephenson E; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Su Y; Institute for Systems Biology, Seattle, WA 98109, USA., Gardner L; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Yuan D; Institute for Systems Biology, Seattle, WA 98109, USA., Chen D; Institute for Systems Biology, Seattle, WA 98109, USA., Goldman J; Institute for Systems Biology, Seattle, WA 98109, USA; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA; Division of Allergy & Infectious Diseases, University of Washington, Seattle, WA 98109, USA., Rosenstiel P; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany., Schmidt SV; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Latz E; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Hrusovsky K; Quanterix Corporation, Billerica, MA, USA., Ball AJ; Quanterix Corporation, Billerica, MA, USA., Johnson JM; Quanterix Corporation, Billerica, MA, USA., Koenig PA; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany; Core Facility Nanobodies, Medical Faculty, University of Bonn, Bonn, Germany., Schmidt FI; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany; Core Facility Nanobodies, Medical Faculty, University of Bonn, Bonn, Germany., Haniffa M; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK; NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Department of Dermatology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Heath JR; Institute for Systems Biology, Seattle, WA 98109, USA; Board of Directors of Isoplexis, Branford, CT 06405, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Board of Directors of PACT Pharma, South San Francisco, CA 94080, USA., Kümmerer BM; German Center for Infection Research (DZIF), Germany; Institute of Virology, Medical Faculty, University of Bonn, Bonn, Germany., Keitel V; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Jensen B; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Stubbemann P; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany., Kurth F; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany., Sander LE; Department of Infectious Diseases and Respiratory Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany., Sawitzki B; Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany., Aschenbrenner AC; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Schultze JL; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), PRECISE Platform for Genomics and Epigenomics at DZNE, and University of Bonn, Bonn, Germany., Nattermann J; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany; German Center for Infection Research (DZIF), Germany. Electronic address: jacob.nattermann@ukbonn.de.

Publikováno v: Immunity [Immunity] 2021 Nov 09; Vol. 54 (11), pp. 2650-2669.e14. Date of Electronic Publication: 2021 Sep 04.

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