Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Reuben L Smith"'
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Akademický článek
Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity.
Autor: Reuben L Smith, Josephine M E Tan, Martijs J Jonker, Aldo Jongejan, Thomas Buissink, Steve Veldhuijzen, Antoine H C van Kampen, Stanley Brul, Hans van der Spek
Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187424 (2017)
Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their toxicity has not been fully understood. Mitochondrial dysfunction after chronic exposure to spec
Externí odkaz: https://doaj.org/article/36804a76b9a047ff8edcbcd90b040ad2
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2
Metabolomics and lipidomics in Caenorhabditis elegans using a single-sample preparation
Autor: Michel van Weeghel, Frédéric M. Vaz, Mia L. Pras-Raves, Martin A. T. Vervaart, Jan E. Kammenga, Angela C. M. Luyf, Reuben L. Smith, Bauke V. Schomakers, Arwen W. Gao, Mark G. Sterken, Antoine H C van Kampen, Riekelt H. Houtkooper, Marte Molenaars, Hyung L. Elfrink, Georges E. Janssens
Publikováno v: Disease models & mechanisms, 14(4):dmm.047746. Company of Biologists Ltd
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms 14 (2021) 4
Disease Models & Mechanisms, 14(4)
Comprehensive metabolomic and lipidomic mass spectrometry methods are in increasing demand; for instance, in research related to nutrition and aging. The nematode Caenorhabditis elegans is a key model organism in these fields, owing to the large repo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be939dab8bd914eaeca1e4a5e09203b6
https://pure.amc.nl/en/publications/metabolomics-and-lipidomics-in-caenorhabditis-elegans-using-a-singlesample-preparation(60377654-87fa-4b5b-beef-51a6a6105f03).html
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3
Reduced ech-6 Expression Attenuates Fat-induced Premature Aging in C. elegans
Autor: Louis R. Lapierre, Arwen W. Gao, Daan M. Panneman, Frédéric M. Vaz, Aldo Jongejan, Yasmine J. Liu, Georges E. Janssens, Alyson W. MacInnes, Michel van Weeghel, Melissa J. Silvestrini, Reuben L. Smith, Riekelt H. Houtkooper
SUMMARYDeregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14949a0bf393a91ecb138a82c15539f3
https://doi.org/10.1101/2020.11.02.364760
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6
Reduced ech-6 Expression Attenuates Fat-Induced Premature Aging in C. Elegans
Autor: Georges E. Janssens, Louis R. Lapierre, Melissa J. Silvestrini, Reuben L. Smith, Aldo Jongejan, Arwen W. Gao, Michel van Weeghel, Alyson W. MacInnes, Daan M. Panneman, Yasmine J. Liu, Riekelt H. Houtkooper, Frédéric M. Vaz
Publikováno v: SSRN Electronic Journal.
Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0d5bd712940d5c521607b0f8c2aae8a
https://doi.org/10.2139/ssrn.3728947
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7
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Autor: Rob C. I. Wüst, Maarten R. Soeters, Riekelt H. Houtkooper, Reuben L. Smith
Publikováno v: Smith, R L, Soeters, M R, Wüst, R C I & Houtkooper, R H 2018, ' Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease ', Endocrine Reviews, vol. 39, no. 4, pp. 489-517 . https://doi.org/10.1210/er.2017-00211
Endocrine Reviews
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and utilization, dependent on availability and requirement, is known as metabolic flexibility. In this review, we discuss the breadth and depth of metabolic flexi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e961efe50db37f50bc3f5b1813d6b0
https://hdl.handle.net/1871.1/1504ce9b-ccc3-488c-a275-e8e605c40327
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8
Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans
Autor: Jelmi uit de Bos, Reuben L. Smith, Mark G. Sterken, Riekelt H. Houtkooper, Jan E. Kammenga, Arwen W. Gao
Publikováno v: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1864(9B), 2697-2706. Elsevier
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Biochimica et Biophysica Acta. Molecular Basis of Disease 1864 (2018) 9A
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1864(9A), 2697-2706
The biological mechanisms of aging have been studied in depth and prominent findings in this field promote the development of new therapies for age-associated disorders. Various model organisms are used for research on aging; among these, the nematod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbeebf3a6c096bcd24e2b87812ac327
https://pure.amc.nl/en/publications/forward-and-reverse-genetics-approaches-to-uncover-metabolic-aging-pathways-in-caenorhabditis-elegans(06fd99c7-897e-4463-8b4b-86d731181d13).html
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9
Identification of key pathways and metabolic fingerprints of longevity in C. elegans
Autor: Arwen W. Gao, Michel van Weeghel, Rashmi Kamble, Georges E. Janssens, Reuben L. Smith, Riekelt H. Houtkooper
Publikováno v: Experimental gerontology, 113, 128-140. Elsevier Inc.
Experimental Gerontology
Impaired insulin/IGF-1 signaling (IIS) and caloric restriction (CR) prolong lifespan in the nematode C. elegans. However, a cross comparison of these longevity pathways using a multi-omics integration approach is lacking. In this study, we aimed to i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f5a47dce67a09da7c3cde06aa8260c
https://pure.amc.nl/en/publications/identification-of-key-pathways-and-metabolic-fingerprints-of-longevity-in-c-elegans(88024c74-6229-48f5-abcd-2f6bca46d9a0).html
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10
Identification of key pathways and metabolic fingerprints of longevity in C. elegans
Autor: Michel van Weeghel, Reuben L. Smith, Arwen W. Gao, Rashmi Kamble, Riekelt H. Houtkooper
Impaired insulin/IGF-1 signaling (IIS) pathway and caloric restriction (CR) are two well-established interventions to prolong lifespan in worm C. elegans. However, a cross comparison of these longevity pathways using a multi-omics integration approac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b841b3372830aa1d938d2068cd53748d
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