Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Reuben L Smith"'
Autor:
Yasmine J. Liu, Arwen W. Gao, Reuben L. Smith, Georges E. Janssens, Daan M. Panneman, Aldo Jongejan, Michel van Weeghel, Frédéric M. Vaz, Melissa J. Silvestrini, Louis R. Lapierre, Alyson W. MacInnes, Riekelt H. Houtkooper
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induce
Externí odkaz:
https://doaj.org/article/d938ea76b080454c99df73b92155dc9b
Autor:
Arwen W. Gao, Iliana A. Chatzispyrou, Rashmi Kamble, Yasmine J. Liu, Katharina Herzog, Reuben L. Smith, Henk van Lenthe, Martin A. T. Vervaart, Arno van Cruchten, Angela C. Luyf, Antoine van Kampen, Mia L. Pras-Raves, Frédéric M. Vaz, Riekelt H. Houtkooper
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Abnormal nutrient metabolism is a hallmark of aging, and the underlying genetic and nutritional framework is rapidly being uncovered, particularly using C. elegans as a model. However, the direct metabolic consequences of perturbations in li
Externí odkaz:
https://doaj.org/article/f244d9a20b94447d85bf084d64d7035a
Autor:
Reuben L Smith, Josephine M E Tan, Martijs J Jonker, Aldo Jongejan, Thomas Buissink, Steve Veldhuijzen, Antoine H C van Kampen, Stanley Brul, Hans van der Spek
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187424 (2017)
Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their toxicity has not been fully understood. Mitochondrial dysfunction after chronic exposure to spec
Externí odkaz:
https://doaj.org/article/36804a76b9a047ff8edcbcd90b040ad2
Autor:
Michel van Weeghel, Frédéric M. Vaz, Mia L. Pras-Raves, Martin A. T. Vervaart, Jan E. Kammenga, Angela C. M. Luyf, Reuben L. Smith, Bauke V. Schomakers, Arwen W. Gao, Mark G. Sterken, Antoine H C van Kampen, Riekelt H. Houtkooper, Marte Molenaars, Hyung L. Elfrink, Georges E. Janssens
Publikováno v:
Disease models & mechanisms, 14(4):dmm.047746. Company of Biologists Ltd
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms 14 (2021) 4
Disease Models & Mechanisms, 14(4)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms 14 (2021) 4
Disease Models & Mechanisms, 14(4)
Comprehensive metabolomic and lipidomic mass spectrometry methods are in increasing demand; for instance, in research related to nutrition and aging. The nematode Caenorhabditis elegans is a key model organism in these fields, owing to the large repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be939dab8bd914eaeca1e4a5e09203b6
https://pure.amc.nl/en/publications/metabolomics-and-lipidomics-in-caenorhabditis-elegans-using-a-singlesample-preparation(60377654-87fa-4b5b-beef-51a6a6105f03).html
https://pure.amc.nl/en/publications/metabolomics-and-lipidomics-in-caenorhabditis-elegans-using-a-singlesample-preparation(60377654-87fa-4b5b-beef-51a6a6105f03).html
Autor:
Louis R. Lapierre, Arwen W. Gao, Daan M. Panneman, Frédéric M. Vaz, Aldo Jongejan, Yasmine J. Liu, Georges E. Janssens, Alyson W. MacInnes, Michel van Weeghel, Melissa J. Silvestrini, Reuben L. Smith, Riekelt H. Houtkooper
SUMMARYDeregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14949a0bf393a91ecb138a82c15539f3
https://doi.org/10.1101/2020.11.02.364760
https://doi.org/10.1101/2020.11.02.364760
Autor:
Riekelt H. Houtkooper, Michel van Weeghel, Frédéric M. Vaz, Georges E. Janssens, Antoine H. C. van Kampen, Jan E. Kammenga, Mark G. Sterken, Reuben L. Smith, Angela C. Luyf, Mia L. Pras-Raves, Martin A.T. Vervaart, Arwen W. Gao, Hyung L. Elfrink, Bauke V. Schomakers, Marte Molenaars
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26746502a6dab6d3785e57a2416c1aba
https://doi.org/10.15252/rc.2022792469
https://doi.org/10.15252/rc.2022792469
Autor:
Georges E. Janssens, Angela C. M. Luyf, Martin A. T. Vervaart, Hyung L. Elfrink, Bauke V. Schomakers, Marte Molenaars, Jan E. Kammenga, Arwen W. Gao, Michel van Weeghel, Reuben L. Smith, Frédéric M. Vaz, Mia L. Pras-Raves, Mark G. Sterken, Antoine H C van Kampen, Riekelt H. Houtkooper
Comprehensive metabolomic and lipidomic mass spectrometry methods are in increasing demand, for instance in research related to nutrition and aging. The nematode C. elegans is a key model organism in these fields, due to the large repository of avail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f0c0d6b93ec06294d362f172392cd9c
https://doi.org/10.1101/2020.07.06.190017
https://doi.org/10.1101/2020.07.06.190017
Autor:
Georges E. Janssens, Louis R. Lapierre, Melissa J. Silvestrini, Reuben L. Smith, Aldo Jongejan, Arwen W. Gao, Michel van Weeghel, Alyson W. MacInnes, Daan M. Panneman, Yasmine J. Liu, Riekelt H. Houtkooper, Frédéric M. Vaz
Publikováno v:
SSRN Electronic Journal.
Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0d5bd712940d5c521607b0f8c2aae8a
https://doi.org/10.2139/ssrn.3728947
https://doi.org/10.2139/ssrn.3728947
Publikováno v:
Smith, R L, Soeters, M R, Wüst, R C I & Houtkooper, R H 2018, ' Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease ', Endocrine Reviews, vol. 39, no. 4, pp. 489-517 . https://doi.org/10.1210/er.2017-00211
Endocrine Reviews
Endocrine Reviews
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and utilization, dependent on availability and requirement, is known as metabolic flexibility. In this review, we discuss the breadth and depth of metabolic flexi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e961efe50db37f50bc3f5b1813d6b0
https://hdl.handle.net/1871.1/1504ce9b-ccc3-488c-a275-e8e605c40327
https://hdl.handle.net/1871.1/1504ce9b-ccc3-488c-a275-e8e605c40327
Autor:
Jelmi uit de Bos, Reuben L. Smith, Mark G. Sterken, Riekelt H. Houtkooper, Jan E. Kammenga, Arwen W. Gao
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1864(9B), 2697-2706. Elsevier
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Biochimica et Biophysica Acta. Molecular Basis of Disease 1864 (2018) 9A
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1864(9A), 2697-2706
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Biochimica et Biophysica Acta. Molecular Basis of Disease 1864 (2018) 9A
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1864(9A), 2697-2706
The biological mechanisms of aging have been studied in depth and prominent findings in this field promote the development of new therapies for age-associated disorders. Various model organisms are used for research on aging; among these, the nematod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbeebf3a6c096bcd24e2b87812ac327
https://pure.amc.nl/en/publications/forward-and-reverse-genetics-approaches-to-uncover-metabolic-aging-pathways-in-caenorhabditis-elegans(06fd99c7-897e-4463-8b4b-86d731181d13).html
https://pure.amc.nl/en/publications/forward-and-reverse-genetics-approaches-to-uncover-metabolic-aging-pathways-in-caenorhabditis-elegans(06fd99c7-897e-4463-8b4b-86d731181d13).html