Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Reuben Harris"'
Autor:
Christopher B. Driscoll, Matthew R. Schuelke, Timothy Kottke, Jill M. Thompson, Phonphimon Wongthida, Jason M. Tonne, Amanda L. Huff, Amber Miller, Kevin G. Shim, Amy Molan, Cynthia Wetmore, Peter Selby, Adel Samson, Kevin Harrington, Hardev Pandha, Alan Melcher, Jose S. Pulido, Reuben Harris, Laura Evgin, Richard G. Vile
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine settin
Externí odkaz:
https://doaj.org/article/0b522666697f4ba891fb72be5cba002f
Publikováno v:
Cancer Research. 83:P2-17
APOBEC-catalyzed deamination of cytosine bases is the largest enzymatic and second largest overall source of mutation in cancer. One member from the APOBEC family of enzymes, APOBEC3B (A3B) is overexpressed and dysregulated in many different cancer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbf96cb348042132aa66e58cb4ae018a
https://doi.org/10.1158/1538-7445.sabcs22-p2-17-01
https://doi.org/10.1158/1538-7445.sabcs22-p2-17-01
Autor:
Jesse Boumelha, Sophie de Carné Trécesson, Emily K. Law, Pablo Romero-Clavijo, Matthew A. Coelho, Kevin W. Ng, Edurne Mugarza, Christopher Moore, Sareena Rana, Deborah R. Caswell, Miguel Murillo, David C. Hancock, Prokopios P. Argyris, William L. Brown, Cameron Durfee, Lindsay K. Larson, Rachel I. Vogel, Alejandro Suárez-Bonnet, Simon L. Priestnall, Philip East, Sarah J. Ross, George Kassiotis, Miriam Molina-Arcas, Charles Swanton, Reuben Harris, Julian Downward
Publikováno v:
Cancer Res
Mutations in oncogenes such as KRAS and EGFR cause a high proportion of lung cancers. Drugs targeting these proteins cause tumor regression but ultimately fail to elicit cures. As a result, there is an intense interest in how to best combine targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128d1ca05f75d8769b0a636c3c99db68
https://doi.org/10.1158/0008-5472.can-22-0325
https://doi.org/10.1158/0008-5472.can-22-0325
Autor:
Jordan Naumann, Prokopios Argyris, Michael Carpenter, Harshita Gupta, Yanjun Chen, Nuri Alpay Temiz, Yufan Zhou, Cameron Durfee, Joshua Proehl, Brenda Koniar, Silvestro Conticello, David Largaespada, William Brown, Hideki Aihara, Rachel Vogel, Reuben Harris
Although the APOBEC3 family of single-stranded DNA cytosine deaminases are well-known as antiviral factors, these enzymes are rapidly gaining attention as prominent sources of mutation in cancer. APOBEC3 signature single base substitutions, C-to-T an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70506454ee7ab01083752c19d7ebe159
https://doi.org/10.20944/preprints202305.0072.v1
https://doi.org/10.20944/preprints202305.0072.v1
Autor:
Julian Downward, Reuben Harris, Charles Swanton, Miriam Molina-Arcas, George Kassiotis, Sarah J. Ross, Philip East, Simon L. Priestnall, Alejandro Suárez-Bonnet, Rachel I. Vogel, Lindsay K. Larson, Cameron Durfee, William L. Brown, Prokopios P. Argyris, David C. Hancock, Miguel Murillo, Deborah R. Caswell, Sareena Rana, Christopher Moore, Edurne Mugarza, Kevin W. Ng, Matthew A. Coelho, Pablo Romero-Clavijo, Emily K. Law, Sophie de Carné Trécesson, Jesse Boumelha
Supplementary Data from An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fc3e20f035a7d1519858bb7c34e1ae
https://doi.org/10.1158/0008-5472.22432362
https://doi.org/10.1158/0008-5472.22432362
Autor:
Julian Downward, Reuben Harris, Charles Swanton, Miriam Molina-Arcas, George Kassiotis, Sarah J. Ross, Philip East, Simon L. Priestnall, Alejandro Suárez-Bonnet, Rachel I. Vogel, Lindsay K. Larson, Cameron Durfee, William L. Brown, Prokopios P. Argyris, David C. Hancock, Miguel Murillo, Deborah R. Caswell, Sareena Rana, Christopher Moore, Edurne Mugarza, Kevin W. Ng, Matthew A. Coelho, Pablo Romero-Clavijo, Emily K. Law, Sophie de Carné Trécesson, Jesse Boumelha
Supplementary Table from An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5646e5b6edd1bf21906dd5a24045f7ea
https://doi.org/10.1158/0008-5472.22432356.v1
https://doi.org/10.1158/0008-5472.22432356.v1
Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (Mpro) variants and a robust cell-based assay are used to compare the resistance p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::061f9c97c7edf69dc84297a5b8d4df3c
https://doi.org/10.21203/rs.3.rs-2627723/v1
https://doi.org/10.21203/rs.3.rs-2627723/v1
Autor:
Geoffrey Jameson, Stefan Harjes, Harikrishnan Kurup, Amanda Rieffer, Maitsetseg Bayarjargal, Jana Filichetva, Yongdong Su, Tracy Hale, Vyacheslav Filichev, Elena Harjes, Reuben Harris
The normally antiviral enzyme APOBEC3A1-4 is an endogenous mutagen in many different human cancers5-7, where it becomes hijacked to fuel tumor evolvability. APOBEC3A’s single-stranded DNA C-to-U editing activity1-8 results in multiple mutagenic out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c8eb2348a5c920aea7a02042f61c49
https://doi.org/10.21203/rs.3.rs-2598101/v1
https://doi.org/10.21203/rs.3.rs-2598101/v1
Autor:
Antonio Marra, Andrea Gazzo, Pier Selenica, Xin Pei, Avantika Gupta, Fresia Pareja, Giuseppe Curigliano, Reuben Harris, Nadeem Riaz, Jorge S. Reis-Filho, Sarat Chandarlapaty
Publikováno v:
Cancer Research. 82:PD1-06
Background: Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) enzymes drive genomic instability in breast cancer (BC) characterized by specific single base substitution mutation signatures (COSMIC S2 and S13). Computational alg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac9375659b4381a5c5e87e049bb9d819
https://doi.org/10.1158/1538-7445.sabcs21-pd1-06
https://doi.org/10.1158/1538-7445.sabcs21-pd1-06
Autor:
Alicia Alonso de la Vega, Nuri Temiz, Rafail Tasakis, Kalman Somogyi, Eli Reuveni, Uri Ben-David, Albrecht Stenzinger, Tanja Poth, Fotini Papavasiliou, Reuben Harris, Rocio Sotillo
RNA editing has been described to promote heterogeneity leading to the development of multiple disorders including cancer. The cytosine deaminase APOBEC3B is known to fuel tumor evolution through DNA mutagenesis, but whether it may also function as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8f699a8743a4fbe80f6e17ad3a4b05
https://doi.org/10.21203/rs.3.rs-1715047/v1
https://doi.org/10.21203/rs.3.rs-1715047/v1