Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Retsu Mitsui"'
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 473:1925-1938
Here we investigate mechanisms underlying spontaneous phasic contractions (SPCs) and sympathetic control of contractility in the rat epididymis, a long tubular duct involved in transportation and maturation of sperm. Longitudinal contractions of shor
Publikováno v:
Pflugers Archiv : European journal of physiology. 474(10)
Parathyroid hormone-related protein (PTHrP) released from detrusor smooth muscle (DSM) as the bladder fills acts as an endogenous DSM relaxant to facilitate bladder storage function. Here, the effects of exogenous PTHrP on transient pressure rises (T
Autor:
Christian Steinhäuser, Hidekazu Tanaka, Stefan Passlick, Hikaru Hashitani, Retsu Mitsui, Kenji F. Tanaka, Mitsuhiro Oishi, Ronald Jabs
Publikováno v:
British Journal of Pharmacology. 178:1073-1094
BACKGROUND AND PURPOSE While the bladder vasculature is considered as a target of PDE5 inhibitors to improve bladder storage dysfunctions, its characteristics are largely unknown. Thus, the functional and morphological properties of arteries/arteriol
Publikováno v:
Neurourology and Urodynamics. 39:1667-1678
Aims As PDGFRα (+) cells appear not to suppress the excitability of detrusor smooth muscle by generating SK3-dependent hyperpolarising as proposed in the gastrointestinal tract, we further explored the functional roles of PDGFRα (+) cells in regula
Autor:
Retsu Mitsui, Hikaru Hashitani
Publikováno v:
Journal of Smooth Muscle Research. 56:1-18
Spontaneous rhythmic constrictions known as vasomotion are developed in several microvascular beds in vivo. Vasomotion in arterioles is considered to facilitate blood flow, while venular vasomotion would facilitate tissue metabolite drainage. Mechani
Publikováno v:
European journal of pharmacology. 920
The renal pelvis develops spontaneous phasic contractions (SPCs) that underlie pyeloureteric peristalsis. Increased urine flow into the renal pelvis mechanically stimulates the contractile machinery within the renal pelvis to facilitate the propagati
Publikováno v:
Cell and tissue research. 386(3)
Neurally released nitric oxide (NO) functions as an inhibitory neurotransmitter of urethral but not detrusor smooth muscles while relaxing bladder vasculature and muscularis mucosae (MM). Here, the distribution of nitrergic nerves was examined in the
Publikováno v:
Neurogastroenterology & Motility. 33
Background Constipation is commonly seen in patients with Parkinson's disease associated with a loss of dopaminergic neurons in both central and enteric nervous systems. However, the roles of enteric dopaminergic neurons in developing constipation re
Autor:
Hikaru Hashitani, Retsu Mitsui, Fumio Kinoshita, Ken Lee, Aoi Uchiyama, Shunichi Kajioka, Shunta Hayakawa, Masatoshi Eto
Publikováno v:
Cell and Tissue Research. 379:373-387
Contractile behaviour of the urinary bladder and its sympathetic inhibition during storage phases are not well understood. Here, we explore muscularis mucosae (MM) as a predominant mucosal contractile element and the capability of sympathetic nerves
Autor:
Retsu Mitsui, Hikaru Hashitani
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 471:1025-1040
Mural cells in precapillary arterioles (PCAs) generate spontaneous Ca2+ transients primarily arising from the periodic release of Ca2+ from sarcoendoplasmic reticulum (SR/ER). The Ca2+ release induces Ca2+-activated chloride channel (CaCC)-dependent