Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Reto Caldelari"'
Autor:
Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G. Doench, Arunasalam Naguleswaran, Denis Joly, Martín González-Fernández, Jonas Zemp, Mélanie Borteele, Vassily Hatzimanikatis, Volker Heussler, Sven Rottenberg, Philipp Olias
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Parasitic diseases, particularly malaria (caused by Plasmodium falciparum) and theileriosis (caused by Theileria spp.), profoundly impact global health and the socioeconomic well-being of lower-income countries. Despite recent advances, iden
Externí odkaz:
https://doaj.org/article/6b4b2ca83d7b4ebaa7f6f50164e555c9
Machine learning for predicting Plasmodium liver stage development in vitro using microscopy imaging
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 24, Iss , Pp 334-342 (2024)
Malaria, a significant global health challenge, is caused by Plasmodium parasites. The Plasmodium liver stage plays a pivotal role in the establishment of the infection. This study focuses on the liver stage development of the model organism Plasmodi
Externí odkaz:
https://doaj.org/article/526a79d2a5b54abe97d90832e78665f4
Autor:
Reto Caldelari, Sunil Dogga, Marc W. Schmid, Blandine Franke-Fayard, Chris J. Janse, Dominique Soldati-Favre, Volker Heussler
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-20 (2019)
Abstract Background The complex life cycle of malaria parasites requires well-orchestrated stage specific gene expression. In the vertebrate host the parasites grow and multiply by schizogony in two different environments: within erythrocytes and wit
Externí odkaz:
https://doaj.org/article/728e1abb33eb456fb3fcb7e9917f8a35
Autor:
Morgane Grand, Mishelle Waqasi, Claudia Demarta-Gatsi, Yu Wei, Roger Peronet, Pierre-Henri Commere, Amandine Puig, Jonathan Axelrod, Reto Caldelari, Volker Heussler, Rogerio Amino, Salaheddine Mecheri
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Deciphering the mechanisms by which Plasmodium parasites develop inside hepatocytes is an important step toward the understanding of malaria pathogenesis. We propose that the nature and the magnitude of the inflammatory response in the liver are key
Externí odkaz:
https://doaj.org/article/7029c9f64afe42b884ed6def30da2bfd
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT A crucial step in the life cycle of Plasmodium parasites is the transition from the liver stage to the blood stage. Hepatocyte-derived merozoites reach the blood vessels of the liver inside host cell-derived vesicles called merosomes. The mo
Externí odkaz:
https://doaj.org/article/7b0e0df5fff54219b923e0f97e6701b9
Autor:
Shaifali Jain, Mohd Asad, Reto Caldelari, Gaurav Datta, Shweta Singh, Sumit Rathore, Rebecca R. Stanway, Volker T. Heussler, Asif Mohmmed
The ATP-dependent ClpQY system is a prokaryotic proteasome-like machinery in the mitochondrion of malaria parasite, Plasmodium. This protease system is identified as a validated target for malaria intervention. Here we have identified drug-like small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86ce636788b121d842a6bb2fdc86e94d
https://doi.org/10.1101/2022.05.12.491652
https://doi.org/10.1101/2022.05.12.491652
Autor:
Annina Bindschedler, Jacqueline Schmuckli-Maurer, Rahel Wacker, Nicolas Kramer, Ruth Rehmann, Reto Caldelari, Volker T. Heussler
Publikováno v:
Cellular Microbiology.
The protozoan parasite Plasmodium, causative agent of malaria, initially invades and develops in hepatocytes where it resides in a parasitophorous vacuole (PV). A single invaded parasite develops into thousands of daughter parasites. Survival of the
Autor:
Volker Heussler, Mariana De Niz, Gesine Kaiser, Won Do Heo, Reto Caldelari, Benoît Zuber, Carolina Agop-Nersesian
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
De Niz, Mariana; Caldelari, Reto; Kaiser, Gesine; Zuber, Benoît; Heo, Won Do; Heussler, Volker T.; Agop-Nersesian, Carolina (2021). Hijacking of the host cell Golgi by Plasmodium berghei liver stage parasites. Journal of cell science, 134(10) Company of Biologists Limited 10.1242/jcs.252213
article-version (VoR) Version of Record
De Niz, Mariana; Caldelari, Reto; Kaiser, Gesine; Zuber, Benoît; Heo, Won Do; Heussler, Volker T.; Agop-Nersesian, Carolina (2021). Hijacking of the host cell Golgi by Plasmodium berghei liver stage parasites. Journal of cell science, 134(10) Company of Biologists Limited 10.1242/jcs.252213
The intracellular lifestyle represents a challenge for the rapidly proliferating liver stage Plasmodium parasite. In order to scavenge host resources, Plasmodium has evolved the ability to target and manipulate host cell organelles. Using dynamic flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62443702230a8cbccdf91d6506ba9dc1
Autor:
Robert L. Summers, Annette Habluetzel, Stefania Lamponi, Sandra Gemma, Rowena E. Martin, Sarah H. Shafik, Stefano Federico, Reto Caldelari, Donatella Taramelli, Luca Pozzetti, Giuseppe Campiani, Sarah D'Alessandro, Stefania Butini, Simone K. Babij, Nicola Relitti, Sofia Tapanelli
Due to the surge in resistance to common therapies, malaria remains a significant concern to human health worldwide. In chloroquine (CQ)-resistant (CQ-R) strains of Plasmodium falciparum, CQ and related drugs are effluxed from the parasite’s digest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8956bb26e1162a62798dcc944865de
http://hdl.handle.net/11365/1141531
http://hdl.handle.net/11365/1141531
Autor:
Beatrice Gorelli, Alessandra Vallone, Sarah D'Alessandro, Koen J. Dechering, Karin J.M. Koolen, Stefania Butini, Simone Brogi, Silvia Parapini, Stefania Lamponi, Reto Caldelari, Margherita Brindisi, Gloria Alfano, Fabio Fusi, Sandra Gemma, Giulia Chemi, Joseph M. Jez, Giuseppe Campiani, Donatella Taramelli, Simona Saponara, Soon Goo Lee
Publikováno v:
European Journal of Medicinal Chemistry. 150:698-718
Therapies addressing multiple stages of Plasmodium falciparum life cycle are highly desirable for implementing malaria elimination strategies. MMV019918 (1, 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine) was selected