Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Reto, Horst"'
Autor:
James Schiemer, Andrew Maxwell, Reto Horst, Shenping Liu, Daniel P. Uccello, Kris Borzilleri, Nisha Rajamohan, Matthew F. Brown, Matthew F. Calabrese
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Bridging covalent ligand discovery with chimeric degrader design has emerged as a mechanism to target proteins that lack enzymatic activity or are intractable. Here, the authors use biochemical and cellular tools to deconvolute the role of covalent m
Externí odkaz:
https://doaj.org/article/8332ec11fd3e488aa9daf64205146e29
Autor:
Roberto R. Gil, Chris Limberakis, Kathleen A. Farley, Ricardo Lira, Justin Bellenger, Ye Che, Martin R. M. Koos, Leandro F. Gil‐Silva, Reto Horst
Publikováno v:
Angewandte Chemie International Edition. 60:26314-26319
Determination of the solution conformation of both small organic molecules and peptides in water remains a substantial hurdle in using NMR solution conformations to guide drug design due to the lack of easy to use alignment media. Herein we report th
Autor:
Xidong Feng, Ye Che, Adam M. Gilbert, Reto Horst, Kris A. Borzilleri, Matthew Merrill Hayward, Carolyn A. Leverett, James Schiemer, Yilin Meng, Justin I. Montgomery, Matthew F. Calabrese, Mark C. Noe, Daniel P. Uccello, Stephen P. Brown, Matthew Frank Brown, Yingrong Xu
Publikováno v:
Nature Chemical Biology. 17:152-160
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growi
Autor:
Matthew T. Eddy, Ming-Yue Lee, Zhan-Guo Gao, Kate L. White, Tatiana Didenko, Reto Horst, Martin Audet, Pawel Stanczak, Kyle M. McClary, Gye Won Han, Kenneth A. Jacobson, Raymond C. Stevens, Kurt Wüthrich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ebce4ba94d100175bdc7211c7a2232
https://doi.org/10.1142/9789811235795_0023
https://doi.org/10.1142/9789811235795_0023
Autor:
Reto Horst, Kurt Wüthrich
Publikováno v:
Bio-Protocol, Vol 5, Iss 14 (2015)
Reconstitution of integral membrane proteins (IMP) in aqueous solutions of detergent micelles has been extensively used in structural biology, using either X-ray crystallography or NMR in solution. Further progress could be achieved by establishing a
Externí odkaz:
https://doaj.org/article/14b478cc9bd44985aa9ac42ba4c48568
Publikováno v:
Journal of biomolecular NMR. 74(10-11)
Nuclear magnetic resonance (NMR) spectroscopy has evolved into a powerful tool within drug discovery over the last two decades. While traditionally being used by medicinal chemists for small molecule structure elucidation, it can also be a valuable t
Autor:
James, Schiemer, Reto, Horst, Yilin, Meng, Justin I, Montgomery, Yingrong, Xu, Xidong, Feng, Kris, Borzilleri, Daniel P, Uccello, Carolyn, Leverett, Stephen, Brown, Ye, Che, Matthew F, Brown, Matthew M, Hayward, Adam M, Gilbert, Mark C, Noe, Matthew F, Calabrese
Publikováno v:
Nature chemical biology. 17(2)
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growi
Autor:
Amy Brault, Leslie Anthony Dakin, Fabien Vincent, Reto Horst, James F. Smith, John I. Trujillo, Darren Dumlao, Laura J. Byrnes, Daniel C. Schmitt, Suman Shanker, Justin Hall, Ann Aulabaugh, Jimson Wong, Matt Griffor, Hong Wang, Erik C. Ralph
Publikováno v:
Protein Science. 26:2367-2380
Cyclic GMP-AMP synthase (cGAS) is activated by ds-DNA binding to produce the secondary messenger 2ʹ,3ʹ-cGAMP. cGAS is an important control point in the innate immune response; dysregulation of the cGAS pathway is linked to autoimmune diseases while
Autor:
Zhan-Guo Gao, Kyle M. McClary, Kurt Wüthrich, Tatiana Didenko, Gye Won Han, Pawel Stanczak, Raymond C. Stevens, Kenneth A. Jacobson, Martin Audet, Matthew T. Eddy, Ming-Yue Lee, Reto Horst
Publikováno v:
SSRN Electronic Journal.
Structural plasticity enabling signal transfer over 30 A from the extracellular drug binding site of the adenosine A2A receptor (A2AAR) to the intracellular surface was characterized using NMR spectroscopy in solution. Based on Trp and Gly assignment
Autor:
Jay Pandit, Jake Hobbs, Agnieszka Konopacka, Toni Taylor, Edward B. Stevens, Shenping Liu, Sigourney Bell, Gareth T. Young, Lily T. Y. Cho, John D. Knafels, Rubben Torella, David C. Pryde, Reto Horst, Aristos J. Alexandrou, Jane M. Withka, Alexandre J.C. Loucif
Publikováno v:
Structure (London, England : 1993). 26(4)
Summary Small conductance potassium (SK) ion channels define neuronal firing rates by conducting the after-hyperpolarization current. They are key targets in developing therapies where neuronal firing rates are dysfunctional, such as in epilepsy, Par