Výsledky vyhledávání - "Retinal Vessels/drug effects"

ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

Autor: Rothschild, Pierre-Raphaël, Salah, Sawsen, Berdugo, Marianne, Gelize, Emmanuelle, Delaunay, Kimberley, Naud, Marie-Christine, Klein, Christophe, Moulin, Alexandre, Savoldelli, Michèle, Bergin, Ciara, Jeanny, Jean-Claude, Jonet, Laurent, Arsenijevic, Yvan, Behar-Cohen, Francine, Crisanti, Patricia

Publikováno v: Scientific reports, vol. 7, no. 1, pp. 8834
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-07329-y⟩
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-07329-y⟩

In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. Rho-associated kinase (ROCK), an effector of the small GTPase Rho, involved in cytoskeleton dynamic re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2398ee2c24a38534d0cc0a09062c7f44
https://serval.unil.ch/resource/serval:BIB_BE7FCF2F7BE8.P001/REF.pdf

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Glucocorticoids exert direct toxicity on microvasculature: analysis of cell death mechanisms

Autor: Ikram El Zaoui, Alicia Torriglia, Francine Behar-Cohen

Publikováno v: Toxicological Sciences, vol. 143, no. 2, pp. 441-453

Glucocorticoids (GCs) are routinely administered systemically or injected into the eye when treating numerous ocular diseases; however, their toxicity on the retinal microvasculature has not been previously investigated. In this article, the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e9cc38d9fa9880134d7452c309a05a
https://serval.unil.ch/notice/serval:BIB_EBC4BA09C322

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Protective Effects of Antithrombin III on Retinal Ischemia/Reperfusion Injury in Rats: A Histopathologic Study

Autor: Ozden S, Muftuoglu S, Tatlipinar S, Kaymaz F, Yildirim C, Yaylali V, Ozbay D

Publikováno v: European Journal of Ophthalmology. 15:367-373

PURPOSE. To investigate the effect of antithrombin III (AT III) on retinal ischemia/reperfusion (I/R) injury in rats. METHODS. The study was carried out on 10 Wistar albino rats (20 eyes) and four-vessel occlusion method was employed to induce retina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246db6247153221ad609355cda7f8b6b
https://doi.org/10.1177/112067210501500309

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Vascular localization of heparan sulfate proteoglycans in retinas of patients with diabetes mellitus and in VEGF-induced retinopathy using domain-specific antibodies

Autor: A. N. Witmer, Gijs F.J.M. Vrensen, J. van den Born, Reinier O. Schlingemann

Publikováno v: Current Eye Research, 22(3), 190-197
Current eye research, 22(3), 190-197. Taylor and Francis Ltd.

PURPOSE: The Steno hypothesis (Deckert et al. ) states that in diabetes mellitus (DM), changes in vascular heparan sulfate proteoglycan (HSPG) expression are involved in systemic endothelial dysfunction and increased capillary permeability. In diabet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef76f561befff0d59e2e0d92cd602fa0
https://doi.org/10.1076/ceyr.22.3.190.5519

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Genistein, a protein tyrosine kinase inhibitor, ameliorates retinal degeneration after ischemia-reperfusion injury in rat

Autor: A, Hayashi, A W, Weinberger, H C, Kim, E, de Juan

Publikováno v: Investigative Ophthalmology & Visual Science, Vol. 38, No 6 (1997) pp. 1193-1202

The authors sought to determine the effect of genistein, a naturally occurring protein tyrosine kinase inhibitor, in a model of ischemia-reperfusion injury in the rat retina.Ischemia-reperfusion injury was induced by temporary optic nerve ligation. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::449b8eebfa745c979fe2622d7510b313
https://archive-ouverte.unige.ch/unige:99148

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Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy

Autor: Daya R. Varma, Yves Courtois, Karel Geboes, Sonia Brault, Daniella Checchin, Francine Behar-Cohen, Florian Sennlaub, Bupe R. Mwaikambo, Alejandro Vazquez-Tello, Sylvain Chemtob, Ahmed M. Abu El-Asrar, Fernand Gobeil, Martin Beauchamp, Pierre Lachapelle, Huy Ong, F. Valamanesh

Publikováno v: Europe PubMed Central
Circulation, vol. 108, no. 2, pp. 198-204
Circulation
Circulation, American Heart Association, 2003, 108 (2), pp.198-204. ⟨10.1161/01.CIR.0000080735.93327.00⟩

Background— Intravitreal neovascular diseases, as in ischemic retinopathies, are a major cause of blindness. Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase (COX)–2 promotes tumor angiogenesis, we investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c63462fb4e0ebba326cc15f1437dda
http://europepmc.org/abstract/med/12821538

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