NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats.

Autor: Bravo D; Laboratorio de Neurobiología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170022, Chile.; Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Santiago 9170022, Chile., Zepeda-Morales K; Laboratorio de Neurobiología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170022, Chile., Maturana CJ; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA., Retamal JS; Laboratorio de Neurobiología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170022, Chile.; Bluestone Center, New York University, New York, NY 10010, USA., Hernández A; Laboratorio de Neurobiología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170022, Chile., Pelissier T; Laboratorio de Neurobiología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170022, Chile., Barra R; Centro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9170022, Chile., Sáez-Briones P; Laboratorio de Neurofarmacología y Comportamiento, Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago 9170022, Chile., Burgos H; Escuela de Psicología, Facultad de Medicina y Ciencias de la Salud, Universidad Mayor, Santiago 7570008, Chile., Constandil L; Laboratorio de Neurobiología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9170022, Chile.; Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Santiago 9170022, Chile.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 16; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 16.

Mice expressing fluorescent PAR 2 reveal that endocytosis mediates colonic inflammation and pain.

Autor: Latorre R; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010., Hegron A; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010., Peach CJ; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010., Teng S; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010., Tonello R; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010., Retamal JS; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010., Klein-Cloud R; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010., Bok D; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010., Jensen DD; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010., Gottesman-Katz L; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010., Rientjes J; Gene Modification Platform, Monash University, Clayton, VIC 3168, Australia., Veldhuis NA; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Poole DP; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Schmidt BL; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010., Pothoulakis CH; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Rankin C; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Xie Y; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Koon HW; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Bunnett NW; Department of Molecular Pathobiology, Neuroscience Institute, New York University, New York, NY 10010; nwb2@nyu.edu.; Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10010.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Feb 08; Vol. 119 (6).

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.

Autor: Mai QN; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Shenoy P; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Quach T; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Retamal JS; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Gondin AB; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Yeatman HR; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Aurelio L; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Conner JW; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Poole DP; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Canals M; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, The University of Nottingham Medical School, Nottingham, UK; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, the Midlands, UK., Nowell CJ; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Graham B; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Davis TP; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia., Briddon SJ; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, The University of Nottingham Medical School, Nottingham, UK; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, the Midlands, UK., Hill SJ; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, The University of Nottingham Medical School, Nottingham, UK; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, the Midlands, UK., Porter CJH; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Bunnett NW; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, Australia; Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA. Electronic address: nwb2@nyu.edu., Halls ML; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address: michelle.halls@monash.edu., Veldhuis NA; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address: nicholas.veldhuis@monash.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100345. Date of Electronic Publication: 2021 Jan 28.

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain.

Autor: Ramírez-García PD; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Retamal JS; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Shenoy P; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Imlach W; Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Sykes M; Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Truong N; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Constandil L; Laboratory of Neurobiology, Center for the Development of Nanoscience and Nanotechnology (CEDENNA), University of Santiago de Chile, Santiago, Chile., Pelissier T; Laboratory of Neurobiology, Center for the Development of Nanoscience and Nanotechnology (CEDENNA), University of Santiago de Chile, Santiago, Chile., Nowell CJ; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Khor SY; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Layani LM; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Lumb C; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Poole DP; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Lieu T; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Stewart GD; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Mai QN; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Jensen DD; Departments of Surgery and Pharmacology, Columbia University Vagelos College of Physicians and Surgeons, Columbia University in the City of New York, New York , NY, USA., Latorre R; Departments of Surgery and Pharmacology, Columbia University Vagelos College of Physicians and Surgeons, Columbia University in the City of New York, New York , NY, USA., Scheff NN; Bluestone Centre for Clinical Research, New York University College of Dentistry, New York, NY, USA., Schmidt BL; Bluestone Centre for Clinical Research, New York University College of Dentistry, New York, NY, USA., Quinn JF; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Whittaker MR; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Veldhuis NA; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. nicholas.veldhuis@monash.edu.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia. nicholas.veldhuis@monash.edu., Davis TP; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. thomas.p.davis@monash.edu.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia. thomas.p.davis@monash.edu.; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia. thomas.p.davis@monash.edu., Bunnett NW; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. nwb2@nyu.edu.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia. nwb2@nyu.edu.; Departments of Surgery and Pharmacology, Columbia University Vagelos College of Physicians and Surgeons, Columbia University in the City of New York, New York , NY, USA. nwb2@nyu.edu.; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia. nwb2@nyu.edu.

Publikováno v: Nature nanotechnology [Nat Nanotechnol] 2019 Dec; Vol. 14 (12), pp. 1150-1159. Date of Electronic Publication: 2019 Nov 04.