Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Reta S. Gibbons"'
Autor:
George S. Deepe, Reta S. Gibbons
Publikováno v:
The Journal of Infectious Diseases. 200:142-151
Host defenses against Histoplasma capsulatum require the action of several cytokines. Here, we explored the influence of interleukin (IL)-17 and IL-23 on immunity to H. capsulatum infection in mice. In lungs, synthesis of IL-17 was up-regulated durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b097afaadefefda34d2bc06b683b065
https://doi.org/10.1086/599333
https://doi.org/10.1086/599333
Publikováno v:
The Journal of Immunology. 176:4361-4368
Pulmonary inflammation, abnormalities in alveolar type II cell and macrophage morphology, and pulmonary fibrosis are features of Hermansky-Pudlak Syndrome (HPS). We used the naturally occurring “pearl” HPS2 mouse model to investigate the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c811cf432e702c44abf58171a0e5068
https://doi.org/10.4049/jimmunol.176.7.4361
https://doi.org/10.4049/jimmunol.176.7.4361
Autor:
Reta S. Gibbons, George S. Deepe
Publikováno v:
The Journal of Infectious Diseases. 193:322-330
We examined whether neutralization of tumor necrosis factor (TNF)-alpha after intranasal exposure of mice to Histoplasma capsulatum was necessary for control of primary or secondary infection. All mice given monoclonal antibody to TNF-alpha on the da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554b5c60b676f3f82519d5b00c0590c9
https://doi.org/10.1086/498981
https://doi.org/10.1086/498981
Autor:
Satvir S. Tevethia, Lance F. Barton, George S. Deepe, John J. Monaco, Yunjung Cho, Todd D. Schell, Reta S. Gibbons, Herbert A. Runnels
Publikováno v:
The Journal of Immunology. 172:3948-3954
Protein complexes of the 28-kDa proteasome activator (PA28) family activate the proteasome and may alter proteasome cleavage specificity. Initial investigations have demonstrated a role for the IFN-γ-inducible PA28α/β complex in Ag processing. Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c922b72140405b61c382eb1f4bb20baa
https://doi.org/10.4049/jimmunol.172.6.3948
https://doi.org/10.4049/jimmunol.172.6.3948
Autor:
Reta S. Gibbons, Alexander Kuzmenko, George S. Deepe, Susan R. Ward, Huixing Wu, Francis X. McCormack
Publikováno v:
Journal of Biological Chemistry. 278:36250-36256
Histoplasma capsulatum (Hc) is a facultative intracellular fungal pathogen that causes acute and chronic pneumonia. In this study, we investigated the role of the pulmonary collectins, surfactant proteins (SP) A and D, in the clearance of Hc yeast fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec4f3ada3d7442db61ad8cd43bf19d1
https://doi.org/10.1074/jbc.m303086200
https://doi.org/10.1074/jbc.m303086200
Autor:
Reta S. Gibbons, George S. Deepe
Publikováno v:
The Journal of Infectious Diseases. 186:815-822
Cells expressing the T cell receptor beta-chain variable region (Vbeta) 6 constitute the majority of T cells responding to the protective domain (F3) of heat-shock protein 60 from Histoplasma capsulatum. This subset of cells exhibits a T helper type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39055bb012e4057755224f5f18dc8a7
https://doi.org/10.1086/342602
https://doi.org/10.1086/342602
Autor:
Reta S. Gibbons, George S. Deepe
Publikováno v:
Infection and Immunity. 70:3759-3767
Vaccination with heat shock protein 60 (Hsp60) fromHistoplasma capsulatuminduces a protective immune response in mice. We explored the cellular and molecular requirements for the efficacy of recombinant Hsp60 in mice. Depletion of CD4+, but not CD8+,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a655241fdb437a64e71346981bd8d965
https://doi.org/10.1128/iai.70.7.3759-3767.2002
https://doi.org/10.1128/iai.70.7.3759-3767.2002
Publikováno v:
Infection and Immunity. 67:624-629
The Histoplasma capsulatum URA5 gene, which has recently been cloned and disrupted by allelic replacement, encodes orotidine-5′-monophosphate pyrophosphorylase. Inactivation of URA5 by either targeted or UV mutagenesis results in disruption of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200ae01cd730dd655f3bcfa15da61c1a
https://doi.org/10.1128/iai.67.2.624-629.1999
https://doi.org/10.1128/iai.67.2.624-629.1999
Numerous in vitro studies have demonstrated that Histoplasma capsulatum is engulfed by the diverse populations of phagocytic cells including monocytes/macrophages (Mφ), immature dendritic cells (DC), and neutrophils. The in vivo distribution of H. c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d9b4e74cc3d2c015cc556947832dea
https://europepmc.org/articles/PMC2516902/
https://europepmc.org/articles/PMC2516902/
Autor:
Reta S. Gibbons, George S. Deepe
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 180(2)
In both humans and mice, treatment with TNF-α antagonists is associated with serious infectious complications including disseminated histoplasmosis. The mechanisms by which inhibition of endogenous TNF-α alter protective immunity remain obscure. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187a6ca4fcf488876f7cfa510e802497
https://pubmed.ncbi.nlm.nih.gov/18178849
https://pubmed.ncbi.nlm.nih.gov/18178849