Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function

Autor: Bellmann, Lydia, Zelle-Rieser, Claudia, Milne, Paul, Resteu, Anastasia, Tripp, Christoph H., Hermann-Kleiter, Natascha, Zaderer, Viktoria, Wilflingseder, Doris, Hörtnagl, Paul, Theochari, Maria, Schulze, Jessica, Rentzsch, Mareike, Del Frari, Barbara, Collin, Matthew, Rademacher, Christoph, Romani, Nikolaus, Stoitzner, Patrizia

Publikováno v: In Journal of Investigative Dermatology January 2021 141(1):84-94

Scientific Business Abstracts.

Autor: Cooles F; Newcastle University, Newcastle Upon Tyne, UK., Vidal-Pedrola G; Newcastle University, Newcastle Upon Tyne, UK., Naamane N; Newcastle University, Newcastle Upon Tyne, UK., Pratt A; Newcastle University, Newcastle Upon Tyne, UK., Barron-Millar B; Newcastle University, Newcastle Upon Tyne, UK., Anderson A; Newcastle University, Newcastle Upon Tyne, UK., Hilkens C; Newcastle University, Newcastle Upon Tyne, UK., Casement J; Newcastle University, Newcastle Upon Tyne, UK., Bondet V; Pasteur Institue, Paris, France., Duffy D; Pasteur Institue, Paris, France., Zhang F; Harvard University, Boston, MA, USA., Shukla R; Newcastle University, Newcastle Upon Tyne, UK., Isaacs J; Newcastle University, Newcastle Upon Tyne, UK., Little M; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Payne M; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Coupe N; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Fairfax B; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Taylor CA; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Mackay S; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Milotay G; The Fairfax Lab, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Bos S; Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, UK.; Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK., Hunter B; Flow Cytometry Core and Innovation, Methodology and Application Research Theme, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Mcdonald D; Flow Cytometry Core and Innovation, Methodology and Application Research Theme, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Merces G; Image Analysis Unit, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK., Sheldon G; Medical School, Newcastle University, Newcastle Upon Tyne, UK., Pradère P; Department of Respiratory Diseases, Hôpital Marie Lannelongue, Groupe Hospitalier Paris Saint Joseph and Paris Saclay University, Paris, France., Majo J; Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK., Pulle J; Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK., Vanstapel A; Department of Pathology, University Hospitals Leuven, Leuven, Belgium., Vanaudenaerde BM; Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium., Vos R; Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium.; Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium., Filby AJ; Flow Cytometry Core and Innovation, Methodology and Application Research Theme, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Fisher AJ; Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, UK.; Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK., Collier J; Newcastle University, Newcastle upon Tyne, UK.; Montreal Neurological Institute, McGill University, Montreal, Canada., Lambton J; Newcastle University, Newcastle upon Tyne, UK., Suomi F; University of Helsinki, Helsinki, Finland., Prigent M; Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France.; INSERM U1280, Gif-sur-Yvette, France., Guissart C; University of Montpellier and University Hospital, Montpellier, France., Erskine D; Newcastle University, Newcastle upon Tyne, UK., Rozanska A; Newcastle University, Newcastle upon Tyne, UK., Mccorvie T; Newcastle University, Newcastle upon Tyne, UK., Trimouille A; Groupe Hospitalier Pellegrin, CHU Bordeaux, Bordeaux, France., Imam A; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Hobson E; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Mccullagh H; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Frengen E; Oslo University Hospital and University of Oslo, Oslo, Norway., Misceo D; Oslo University Hospital and University of Oslo, Oslo, Norway., Bjerre A; Oslo University Hospital and University of Oslo, Oslo, Norway., Smeland M; University Hospital of North Norway, Tromsø, Norway., Klingenberg C; University Hospital of North Norway, Tromsø, Norway., Alkuraya F; King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia., Mcfarland R; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Alston C; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Yue W; Newcastle University, Newcastle upon Tyne, UK., Legouis R; Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France.; INSERM U1280, Gif-sur-Yvette, France., Koenig M; University of Montpellier and University Hospital, Montpellier, France., Lako M; Newcastle University, Newcastle upon Tyne, UK., Mcwilliams T; University of Helsinki, Helsinki, Finland., Oláhová M; Newcastle University, Newcastle upon Tyne, UK.; Northumbria University, Newcastle upon Tyne, UK., Taylor R; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Newman W; University of Manchester, Manchester, UK., Harkness R; University of Manchester, Manchester, UK., McDermott J; University of Manchester, Manchester, UK., Metcalfe K; Manchester Centre for Genomic Medicine, Manchester, UK., Khan N; Manchester Centre for Genomic Medicine, Manchester, UK., Macken W; UCL Queen Square Institute of Neurology, London, UK., Pitceathly R; UCL Queen Square Institute of Neurology, London, UK., Record C; UCL Queen Square Institute of Neurology, London, UK., Maroofian R; UCL Queen Square Institute of Neurology, London, UK., Sabir A; West Midlands Clinical Genetics Unit, Birmingham, UK., Santra S; West Midlands Clinical Genetics Unit, Birmingham, UK., Urquhart J; University of Manchester, Manchester, UK., Demain L; University of Manchester, Manchester, UK., Byers H; University of Manchester, Manchester, UK., Beaman G; University of Manchester, Manchester, UK., Yue W; Newcastle University, Newcastle, UK., Taylor R; Newcastle University, Newcastle, UK., Durmusalioglu E; Ege University, Izmir, Turkey., Atik T; Ege University, Izmir, Turkey., Isik E; Ege University, Izmir, Turkey., Cogulu O; Ege University, Izmir, Turkey., Reunert J; University of Münster, Münster, Germany., Marquardt T; University of Münster, Münster, Germany., Ryba L; Charles University, Prague, Czech Republic., Buchert-Lo R; University of Tübingen, Tübingen, Germany., Haack T; University of Tübingen, Tübingen, Germany., Lassuthova P; University of Tübingen, Tübingen, Germany., Polavarapu K; Children's Hospital Eastern Ontario, Ottawa, Canada., Lochmuller H; Children's Hospital Eastern Ontario, Ottawa, Canada., Horvath R; University of Cambridge, Cambridge, UK., Jamieson P; Manchester Centre for Genomic Medicine, Manchester, UK., Reilly M; UCL Queen Square Institute of Neurology, London, UK., O'Keefe R; University of Manchester, Manchester, UK., Boggan R; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Ng YS; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Franklin I; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Alston C; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Blakely E; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Büchner B; Department of Neurology, Friedrich-Baur-Institut, University Hospital of the Ludwig-Maximilians-University (LMU Klinikum), Munich, Germany., Bugiardini E; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK., Colclough K; Exeter Genomics Laboratory, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Feeney C; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Hanna M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK., Hattersley A; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Klopstock T; Department of Neurology, Friedrich-Baur-Institut, University Hospital of the Ludwig-Maximilians-University (LMU Klinikum), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Kornblum C; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Mancuso M; Department of Neurology, Neuromuscular Diseases Section, University Hospital Bonn, Bonn, Germany., Patel K; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Pitceathly R; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK., Pizzamiglio C; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK., Prokisch H; Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy.; Institute of Human Genetics, School of Medicine, Technische Universität München, Munich, Germany., Schäfer J; Institute of Neurogenomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Schaefer A; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Shepherd M; Institute of Neurogenomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Thaele A; Department of Neurology, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Thomas R; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Turnbull D; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK., Gorman G; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Woodward C; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Queen Square Centre for Neuromuscular Diseases, The National Hospital for Neurology and Neurosurgery, London, UK.; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Germany., McFarland R; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Taylor R; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Institute for Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK.; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Cordell H; Neurogenetics Unit, The National Hospital for Neurology and Neurosurgery, London, UK., Pickett S; Centre for Mitochondrial Research, Newcastle University, Newcastle Upon Tyne, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Tsilifis C; Translational And Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Paediatric Immunology & HSCT, Great North Children's Hospital, Newcastle upon Tyne, UK., Pearce M; Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Gennery A; Translational And Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Paediatric Immunology & HSCT, Great North Children's Hospital, Newcastle upon Tyne, UK., Daly A; Newcastle University, Newcastle Upon Tyne, UK., Darlay R, Zatorska M, Worthington S, Anstee Q, Cordell H, Reeves H; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Nizami S; Newcastle University, Newcastle upon Tyne, UK., Mauricio-Muir J; Newcastle University, Newcastle upon Tyne, UK., McCain M; Newcastle University, Newcastle upon Tyne, UK., Singh R; Newcastle University, Newcastle upon Tyne, UK., Wordsworth J; Newcastle University, Newcastle upon Tyne, UK., Kadharusman M; Newcastle University, Newcastle upon Tyne, UK.; University of Indonesia, Jakarta, Indonesia., Watson R; Newcastle University, Newcastle upon Tyne, UK., Masson S; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., McPherson S; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Burt A; Newcastle University, Newcastle upon Tyne, UK., Tiniakos D; Newcastle University, Newcastle upon Tyne, UK.; National & Kapodistrian University of Athens, Athens, Greece., Littler P; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Nsengimana J; Newcastle University, Newcastle upon Tyne, UK., Zhang S; Newcastle University, Newcastle upon Tyne, UK., Mann D; Newcastle University, Newcastle upon Tyne, UK., Jamieson D; Newcastle University, Newcastle upon Tyne, UK., Leslie J; Newcastle University, Newcastle upon Tyne, UK., Shukla R; Northumbria University, Newcastle upon Tyne, UK., Wilson C; Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Betts J; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; University of Sheffield, Sheffield, UK.; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Croall I; University of Sheffield, Sheffield, UK., Hoggard N; University of Sheffield, Sheffield, UK.; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Bennett J; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.; Rheumatology, Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Naamane N; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Hollingsworth KG; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Pratt AG; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.; Rheumatology, Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Egail M; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Feeney C; Wellcome Centre for Mitochondrial Research, Newcastle University Translational and Clinical Research Institute, Newcastle University, UK., Di Leo V; Wellcome Centre for Mitochondrial Research, Newcastle University Translational and Clinical Research Institute, Newcastle University, UK., Taylor RW; Wellcome Centre for Mitochondrial Research, Newcastle University Translational and Clinical Research Institute, Newcastle University, UK.; Highly Specialised Mitochondrial Laboratory, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Dodds R; NIHR Newcastle Biomedical Research Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Anderson AE; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Sayer AA; NIHR Newcastle Biomedical Research Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., Isaacs JD; Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.; Rheumatology, Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, UK., McCracken C; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Condurache DG; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Szabo L; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Elghazaly H; Department of Medicine, Imperial College London and Imperial College NHS Trust, London, UK., Walter F; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Meade A; Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Chakraverty R; Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Harvey N; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK., Manisty C; Institute of Cardiovascular Science, University College London, London, UK., Petersen S; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Neubauer S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Raisi-Estabragh Z; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK., Allen L; Diabetes Research Group, Cardiff University, Cardiff, UK., Taylor P; Diabetes Research Group, Cardiff University, Cardiff, UK., Carlsson A; Lund University, Lund, Sweden., Hagopian W; Pacific Northwest Research Institute, Seattle, USA., Hedlund E; Lund University, Lund, Sweden., Hill A; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK., Jones A; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.; Medical School, University of Exeter, Exeter, UK., Ludvigsson J; Linköping University, Linköping, Sweden., Onengut-Gumuscu S; Center for Public Health Genomics, University of Virginia, Charlottesville, USA., Redondo M; Texas Children's Hospital, Baylor College of Medicine, USA., Rich S; Center for Public Health Genomics, University of Virginia, Charlottesville, USA., Gillespie K; Diabetes and Metabolism Unit, University of Bristol, Bristol, UK., Dayan C; Diabetes Research Group, Cardiff University, Cardiff, UK., Oram R; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.; Medical School, University of Exeter, Exeter, UK., Resteu A; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Wonders K; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Schattenberg J; Department of Internal Medicine II, Saarland University Medical Center, Homburg, Germany., Straub B; Metabolic Liver Research Program, Department of Medicine, University Hospital Mainz, Mainz, Germany., Ekstedt M; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Berzigotti A; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Geier A; Department of Hepatology, University of Würzburg, Würzburg, Germany., Francque S; Department of Gastroenterology Hepatology, Antwerp University Hospital, Antwerp, Belgium.; Translational Sciences in Inflammation and Immunology, Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium., Driessen A; Department of Pathology, Antwerp University Hospital, Antwerp University, Antwerp, Belgium., Boursier J; Service d'Hépato-Gastroentérologie, Centre Hospitalier Universitaire d'Angers, Angers, France.; Laboratoire HIFIH UPRES EA3859, Université d'Angers, Angers, France., Yki-Jarvinen H; University of Helsinki, Helsinki University Hospital, and Minerva Foundation Institute for Medical Research, Helsinki, Finland., Arola J; University of Helsinki, Helsinki University Hospital, and Minerva Foundation Institute for Medical Research, Helsinki, Finland., Aithal G; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK., Holleboom A; Department of Vascular Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands., Verheij J; Department of Vascular Medicine, Amsterdam University Medical Centres, Amsterdam, The Netherlands., Yunis C; Pfizer Global Product Development, New York, USA., Trylesinski A; Advanz Pharmaceuticals, London, UK., Papatheodoridis G; Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens School of Health Sciences, General Hospital of Athens 'Laiko', Athens, Greece., Petta S; Sezione di Gastroenterologia, Dipartimento Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza 'G. D'Alessandro', Università di Palermo, Palermo, Italy., Romero-Gomez M; UCM Digestive Diseases, Virgen del Rocio University Hospital, Instituto de Biomedicina de Sevilla, CIBEREHD, University of Seville, Seville, Spain., Bugianesi E; Division of Gastro-Hepatology, Department of Medical Sciences, City of Health and Science of Turin, University of Turin, Turin, Italy., Paradis V; Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, University Paris-Diderot, Paris, France., Ratziu V; Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, University Paris-Diderot, Paris, France., Tiniakos D; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Pathology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece and., Anstee Q; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Burton J; University of Glasgow, Glasgow, UK., Ciminata G; University of Glasgow, Glasgow, UK., Geue C; University of Glasgow, Glasgow, UK., Quinn T; University of Glasgow, Glasgow, UK., Glover E; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Morais M; Division of Cell Matrix Biology and Regenerative Medicine, University of Manchester, Manchester, UK., Reynolds G; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Centre for Immunology and Inflammatory Diseases, Mass General Research Institute, Harvard Medical School, Boston, USA., Denby L; Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, UK., Ali S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Lennon R; Division of Cell Matrix Biology and Regenerative Medicine, University of Manchester, Manchester, UK., Sheerin N; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Yang F; National Heart & Lung Institute, Imperial College London, London, UK., Zounemat-Kermani N; Department of Computing & Data Science Institute, National Heart & Lung Institute, Imperial College London, London, UK., Dixey P; National Heart & Lung Institute, Imperial College London, London, UK., Adcock IM; Department of Computing & Data Science Institute, National Heart & Lung Institute, Imperial College London, London, UK., Bloom CI; National Heart & Lung Institute, Imperial College London, London, UK., Chung KF; Department of Computing & Data Science Institute, National Heart & Lung Institute, Imperial College London, London, UK., Govaere O; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Hasoon M; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Alexander L; SomaLogic, Inc., Boulder, USA., Cockell S; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Tiniakos D; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Ekstedt M; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Schattenberg JM; I. Department of Medicine, University Hospital Mainz, Mainz, Germany., Boursier J; Hepatology Department, Angers University Hospital, Angers, France., Bugianesi E; Division of Gastro-Hepatology, Department of Medical Sciences, A.O. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Ratziu V; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Sorbonne University, ICAN (Institute of Cardiometabolism and Nutrition), Paris, France., Daly AK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Anstee QM; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Publikováno v: QJM : monthly journal of the Association of Physicians [QJM] 2024 Sep 19. Date of Electronic Publication: 2024 Sep 19.

Ikaros family zinc finger 1 regulates dendritic cell development and function in humans

Autor: Urszula Cytlak, Anastasia Resteu, Delfien Bogaert, Hye Sun Kuehn, Thomas Altmann, Andrew Gennery, Graham Jackson, Attila Kumanovics, Karl V. Voelkerding, Seraina Prader, Melissa Dullaers, Janine Reichenbach, Harry Hill, Filomeen Haerynck, Sergio D. Rosenzweig, Matthew Collin, Venetia Bigley

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

IKZF1 is a transcription factor known to regulate mammalian B-cell development. Here the authors show that IKZF1 is required for human pDC development and regulation of DC cytokine production in patients with IKZF1 haploinsufficiency, findings which

Externí odkaz: https://doaj.org/article/052768b869044a2d884f1ad1b5b273c9

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Notch-dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology

Autor: Egle Kvedaraite, Paul Milne, Ahad Khalilnezhad, Marion Chevrier, Raman Sethi, Hong Kai Lee, Daniel W. Hagey, Tatiana von Bahr Greenwood, Natalia Mouratidou, Martin Jädersten, Nicole Yee Shin Lee, Lara Minnerup, Yingrou Tan, Charles-Antoine Dutertre, Nathan Benac, You Yi Hwang, Josephine Lum, Amos Hong Pheng Loh, Jessica Jansson, Karen Wei Weng Teng, Shabnam Khalilnezhad, Weili Xu, Anastasia Resteu, Hong Liang Tey, Ng Lai Guan, Anis Larbi, Shanshan Wu Howland, Henrik Arnell, Samir E. L. Andaloussi, Jorge Braier, Georgios Rassidakis, Laura Galluzzo, Andrzej Dzionek, Jan-Inge Henter, Jinmiao Chen, Matthew Collin, Florent Ginhoux

Publikováno v: Science Immunology. 7

Langerhans cell histiocytosis (LCH) is a potentially fatal neoplasm characterized by the aberrant differentiation of mononuclear phagocytes, driven by mitogen-activated protein kinase (MAPK) pathway activation. LCH cells may trigger destructive patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153d94f7311e59557ee700e7a07f967f
https://doi.org/10.1126/sciimmunol.add3330