Imaging Meets Cytometry: Analyzing Heterogeneous Functional Microscopic Data from Living Cell Populations

Autor: Matthew Draper, Mara Willems, Reshwan K. Malahe, Alexander Hamilton, Andrei I. Tarasov

Publikováno v: Journal of Imaging, Vol 7, Iss 1, p 9 (2021)

Biological tissue consists of populations of cells exhibiting different responses to pharmacological stimuli. To probe the heterogeneity of cell function, we propose a multiplexed approach based on real‐time imaging of the secondary messenger level

Externí odkaz: https://doaj.org/article/3cfd886d8291400d9b0f143cb87e1e78

Th1-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses

Autor: Yvette den Hartog, S. Reshwan K. Malahe, Wim J. R. Rietdijk, Marjolein Dieterich, Lennert Gommers, Daryl Geers, Susanne Bogers, Debbie van Baarle, Dimitri A. Diavatopoulos, A. Lianne Messchendorp, Renate G. van der Molen, Ester B. M. Remmerswaal, Frederike J. Bemelman, Ron T. Gansevoort, Luuk B. Hilbrands, Jan-Stephan Sanders, Corine H. GeurtsvanKessel, Marcia M. L. Kho, Marlies E. J. Reinders, Rory D. de Vries, Carla C. Baan, on behalf of RECOVAC Consortium

Publikováno v: npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)

Abstract Cytokines are regulators of the immune response against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, the contribution of cytokine-secreting CD4+ and CD8+ memory T cells to the SARS-CoV-2-specific humoral immune resp

Externí odkaz: https://doaj.org/article/1ffaa3b146d545b9acd6be2e7099edbb

Alternative strategies to increase the immunogenicity of COVID-19 vaccines in kidney transplant recipients not responding to two or three doses of an mRNA vaccine (RECOVAC)

Autor: Marcia M L Kho, A Lianne Messchendorp, Sophie C Frölke, Celine Imhof, Vera JCH Koomen, S Reshwan K Malahe, Priya Vart, Daryl Geers, Rory D de Vries, Corine H GeurtsvanKessel, Carla C Baan, Renate G van der Molen, Dimitri A Diavatopoulos, Ester B M Remmerswaal, Debbie van Baarle, Rob van Binnendijk, Gerco den Hartog, Aiko P J de Vries, Ron T Gansevoort, Frederike J Bemelman, Marlies E J Reinders, Jan-Stephan F Sanders, Luuk B Hilbrands, Alferso C. Abrahams, Marije C. Baas, Pim Bouwmans, Marc A.G.J. ten Dam, Lennert Gommers, Dorien Standaar, Marieke van der Heiden, Yvonne M.R. Adema, Marieken J. Boer-Verschragen, Wouter B. Mattheussens, Ria H.L.A. Philipsen, Djenolan van Mourik, Susanne Bogers, Laura L.A. van Dijk, Nynke Rots, Gaby Smits, Marjan Kuijer, Marc H. Hemmelder

Publikováno v: Lancet Infectious Diseases, 23, 307-319
Lancet infectious diseases, 23(3), 307-319. Lancet Publishing Group
Lancet Infectious Diseases, 23(3), 307-319. ELSEVIER SCI LTD
The Lancet Infectious Diseases, 23(3), 307-319. Lancet Publishing Group
Lancet Infectious Diseases, 23, 3, pp. 307-319

BACKGROUND: An urgent need exists to improve the suboptimal COVID-19 vaccine response in kidney transplant recipients (KTRs). We aimed to compare three alternative strategies with a control single dose mRNA-1273 vaccination: a double vaccine dose, he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e83aaaad3fb6c01d134e2f61f346dd
https://pure.eur.nl/en/publications/7c01b0ca-5480-4d2b-acfb-2834cc7589ba

The RECOVAC Immune-response Study: The Immunogenicity, Tolerability, and Safety of COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant

Autor: Priya Vart, Wouter B Mattheussens, Marion Koopmans, Gerco den Hartog, Dimitri A. Diavatopoulos, Luuk B. Hilbrands, Marlies E J Reinders, Djenolan van Mourik, Renate G. van der Molen, Celine Imhof, Marieke van der Heiden, Daryl Geers, C. Baan, Frederike J. Bemelman, Rory D. de Vries, Marcia M L Kho, S Reshwan K Malahe, Debbie van Baarle, Rob van Binnendijk, Ester B. M. Remmerswaal, Jan-Stephan F. Sanders, Corine H. GeurtsvanKessel, Ron T. Gansevoort, Nynke Y. Rots, A. Lianne Messchendorp, Sophie C Frölke

Publikováno v: Transplantation, 106(4), 821-834. Lippincott Williams & Wilkins
Transplantation, 106(4), 821-834. Lippincott Williams and Wilkins
Transplantation, 106(4), 821-834. LIPPINCOTT WILLIAMS & WILKINS
Transplantation, 106, 821-834
Transplantation, 106, 4, pp. 821-834

BACKGROUND: In kidney patients COVID-19 is associated with severely increased morbidity and mortality. A comprehensive comparison of the immunogenicity, tolerability, and safety of COVID-19 vaccination in different cohorts of kidney patients and a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e23dbd02e3411151f1942b9887b11a
https://hdl.handle.net/2066/248732

Boosting the VZV-Specific Memory B and T Cell Response to Prevent Herpes Zoster After Kidney Transplantation

Autor: Marcia M. L. Kho, Willem Weimar, S. Reshwan K. Malahe, Joke M. Zuijderwijk, Ronella de Kuiper, Marieken J. Boer-Verschragen, Annemiek A. van der Eijk, Dennis A. Hesselink, Marlies E. J. Reinders, Nicole M. van Besouw

Publikováno v: Frontiers in Immunology, 13:927734. Frontiers Media S.A.

BackgroundSolid organ transplant recipients are at high risk to develop (complicated) herpes zoster (HZ). Booster vaccination could prevent HZ. However, end-stage renal disease (ESRD) patients show poor immunological responses to vaccinations. We stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e4caf9cb8a8602a62393d4fd681057
https://pubmed.ncbi.nlm.nih.gov/35935972