Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Reshma A. Patel"'
Publikováno v:
Current Opinion in Anaesthesiology. 33:768-773
Purpose of review To discuss the importance of validated tools that measure patient-reported outcomes and their use in ambulatory surgery. Recent findings Sustained increases in ambulatory surgical care reflect advances in surgical techniques and per
Publikováno v:
MOJ Civil Engineering. 3
Publikováno v:
Journal of Applied Clinical Medical Physics
The aim of this work is to establish if the new CT‐based total body irradiation (TBI) planning techniques used at University College London Hospital (UCLH) and Royal Free Hospital (RFH) are comparable to the previous technique at the Middlesex Hosp
Autor:
Prasad Tongaonkar, Paul M. Beringer, Andre J. Ouellette, Gregg B. Fields, Pércio S. Gulko, Patti Tran, Dmitriy Minond, Katie Trinh, Teresina Laragione, Akshay Subramanian, Reshma J. Patel, Justin B. Schaal, Dat Q. Tran, Kevin Roberts, Michael E. Selsted
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187868 (2017)
PLOS ONE
PLoS ONE
PLOS ONE
PLoS ONE
θ-defensins constitute a family of macrocyclic peptides expressed exclusively in Old World monkeys. The peptides are pleiotropic effectors of innate immunity, possessing broad spectrum antimicrobial activities and immunoregulatory properties. Here w
Autor:
Sangita B. Patel, Scott D. Edmondson, Ann E. Weber, Reshma A. Patel, Aleksandr Petrov, Kathryn A. Lyons, Bing Zhu, Joseph K. Wu, Anthony Mastracchio, Shiyao Xu, George J. Eiermann, Ranabir Sinha Roy, Giovanna Scapin, Nancy A. Thornberry, Jason M. Cox, Huaibing He
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4097-4101
A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described. Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34. The potency, selectivity, cross-species DMPK p
Autor:
Sangita B. Patel, Tesfaye Biftu, Nancy A. Thornberry, Reshma A. Patel, Barbara Leiting, Xiaoping Zhang, Joseph K. Wu, Ann E. Weber, Giovanna Scapin, Gui-Bai Liang, Xiaoxia Qian, Suresh B. Singh, Ying-Duo Gao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3706-3710
Probing with tool molecules, and by modeling and X-ray crystallography the binding modes of two structurally distinct series of DPP-4 inhibitors led to the discovery of a rare aromatic fluorine H-bond and the spatial requirement for better biaryl bin
Autor:
Ann E. Weber, Reshma A. Patel, Joseph K. Wu, Aleksandr Petrov, Frank Marsilio, Jennifer E. Kowalchick, KellyAnn D. Pryor, Nancy A. Thornberry, Barbara Leiting, Kathryn A. Lyons, Giovanna Scapin, Huaibing He, George J. Eiermann, Dooseop Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5934-5939
Various beta-amino amides containing triazolopiperazine heterocycles have been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. These compounds display excellent oral bioavailability and good over
Autor:
Reshma A. Patel, Huaibing He, David E. Kaelin, Barbara Leiting, Kathryn A. Lyons, Nancy A. Thornberry, Sangita B. Patel, Ann E. Weber, Abigail Lee Smenton, Alexsandr Petrov, George J. Eiermann, Giovanna Scapin, Joseph L. Duffy, Joseph K. Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5806-5811
A novel series of 4-arylcyclohexylalanine DPP-4 inhibitors was synthesized and tested for inhibitory activity as well as selectivity over the related proline-specific enzymes DPP-8 and DPP-9. Optimization of this series led to 28 (DPP-4 IC(50)=4.8 nM
Autor:
Joseph K. Wu, Reshma A. Patel, Nancy A. Thornberry, Ann E. Weber, Jason M. Cox, Shiyao Xu, Bing Zhu, Barbara Leiting, Kathryn A. Lyons, Scott D. Edmondson, Ranabir Sinha Roy, Bart Harper, Huaibing He, Anthony Mastracchio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4579-4583
Substituted 3-aminopiperidines 3 were evaluated as DPP-4 inhibitors. The inhibitors showed good DPP-4 potency with superb selectivity over other peptidases (QPP, DPP8, and DPP9). Selected DPP-4 inhibitors were further evaluated for their hERG potassi
Autor:
Joseph K. Wu, KellyAnn D. Pryor, Ann E. Weber, George J. Eiermann, Reshma A. Patel, Dooseop Kim, Jinyou Xu, Nancy A. Thornberry, Anthony Mastracchio, Scott D. Edmondson, Jennifer E. Kowalchick, Huaibing He, Barbara Leiting, Kathryn A. Lyons
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3373-3377
A series of beta-aminoamides bearing triazolopiperazines has been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Efforts at optimization of the beta-aminoamide series, which ultimately led to th