Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue

Autor: Melanie Modder, Claudia P. Coomans, Dirk-Jan Saaltink, Mayke M. H. Tersteeg, Janna Hoogduin, Leonie Scholten, Amanda C. M. Pronk, Reshma A. Lalai, Anita Boelen, Andries Kalsbeek, Patrick C. N. Rensen, Erno Vreugdenhil, Sander Kooijman

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Crosstalk between peripheral metabolic organs and the central nervous system is essential for body weight control. At the base of the hypothalamus, β-tanycytes surround the portal capillaries and function as gatekeepers to facilitate transf

Externí odkaz: https://doaj.org/article/dfe49dbfc38e4ce386cd77ee4e307ebf

von Willebrand Factor: A Central Regulator of Arteriovenous Fistula Maturation Through Smooth Muscle Cell Proliferation and Outward Remodeling

Autor: Suzanne L. Laboyrie, Margreet R. de Vries, Alwin de Jong, Hetty C. de Boer, Reshma A. Lalai, Laisel Martinez, Roberto I. Vazquez‐Padron, Joris I. Rotmans

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 16 (2022)

Background Arteriovenous fistula (AVF) maturation failure is a main limitation of vascular access. Maturation is determined by the intricate balance between outward remodeling and intimal hyperplasia, whereby endothelial cell dysfunction, platelet ag

Externí odkaz: https://doaj.org/article/4ac23236191e44ca95256682fd05c9a8

Gene expression changes in the brain of a Cushing's syndrome mouse model

Autor: Jorge Miguel Amaya, Eva M. G. Viho, Hetty C. M. Sips, Reshma A. Lalai, Isabelle Sahut‐Barnola, Typhanie Dumontet, Nathanaëlle Montanier, Alberto M. Pereira, Antoine Martinez, Onno C. Meijer

Publikováno v: Journal of Neuroendocrinology
Journal of Neuroendocrinology, 2022, 34 (4), ⟨10.1111/jne.13125⟩
Journal of neuroendocrinology, 34(4):e13125. Wiley-Blackwell
Journal of Neuroendocrinology, 34(4). WILEY

Excess glucocorticoid exposure affects emotional and cognitive brain functions. The extreme form, Cushing's syndrome, is adequately modelled in the AdKO(2.0) mouse, consequential to adrenocortical hypertrophy and hypercorticosteronemia. We previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23df485f51ad3c28e2f8bb493fa76ec9
https://hal.science/hal-03765716

A Proof-of-Principle Study of the Design and Optimization of a Novel Fluid-Driven Automated Retracting Needle System

Autor: S. Badulescu, M. Koning, K. E. Groeneweg, H. van de Stadt, B. Florijn, Joris I. Rotmans, Reshma A. Lalai, Tim Horeman, M. Boonekamp, Wouter J. Geelhoed

Publikováno v: Journal of Medical Devices, 15(3). ASME

The cannulation of blood vessels is one of the most basic and essential interventions in medical practice. A common adverse event of this procedure is miscannulation with infiltration of the second part of the vessel wall, often resulting in a periva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c530ad4d28a9cd21e23dd7650021458
https://doi.org/10.1115/1.4050661

Liposomal delivery improves the efficacy of prednisolone to attenuate renal inflammation in a mouse model of acute renal allograft rejection

Autor: Sander Kooijman, Carla M. A. van Alem, Jurjen M. Ruben, Josbert M. Metselaar, Jessica Schmitz, Martin Meier, Cees van Kooten, Reshma A. Lalai, Jan Hinrich Bräsen, Christian Klemann, Joris I. Rotmans, Maaike Schilperoort, Faikah Gueler, Anja Thorenz, Rongjun Chen, Elizabeth M. Winter, Song Rong, Katja Derlin, Martina Schmidbauer

Publikováno v: Transplantation, 104(4), 744-753. LIPPINCOTT WILLIAMS & WILKINS
Transplantation: the official journal of the Transplantation Society 104(4), 744-753 (2020). doi:10.1097/TP.0000000000003060
Transplantation

Supplemental Digital Content is available in the text.
Background. Systemic exposure to high-dose corticosteroids effectively combats acute rejection after kidney transplantation, but at the cost of substantial side effects. In this study, a mur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ee2b2802e3d5d942510b4f19cdca4d
https://hdl.handle.net/1887/3185003