PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons

Autor: Jonathan P. Ling, Resham Chhabra, Jonathan D. Merran, Paul M. Schaughency, Sarah J. Wheelan, Jeffry L. Corden, Philip C. Wong

Publikováno v: Cell Reports, Vol 17, Iss 1, Pp 104-113 (2016)

The fidelity of RNA splicing is maintained by a network of factors, but the molecular mechanisms that govern this process have yet to be fully elucidated. We previously found that TDP-43, an RNA-binding protein implicated in neurodegenerative disease

Externí odkaz: https://doaj.org/article/827ff9811a034d8c95b98809101fc1d5

Emerging Use of Nanotechnology in the Treatment of Neurological Disorders

Autor: Resham Chhabra, Andreas M. Grabrucker, Giovanni Tosi

Publikováno v: Università degli studi di Modena e Reggio Emilia-IRIS

Neurological disorders represent one of the major health concerns worldwide. Yet currently employed treatment strategies have not been very successful in the treatment of many of these disorders. One of the root causes of this lack of success is that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5198926b1e5b0881f4669f81ff6a44f6
https://doi.org/10.2174/1381612821666150531164124

Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease

Autor: Marie K. Bondulich, Claire J. Garwood, Diane P. Hanger, Wendy Noble, Joe Atherton, Cara L. Croft, Selina Wray, Ksenia Kurbatskaya, Resham Chhabra, Andreas Jeromin

Publikováno v: Atherton, J, Kurbatskaya, K, Bondulich, M, Croft, C L, Garwood, C J, Chhabra, R, Wray, S, Jeromin, A, Hanger, D P & Noble, W 2014, ' Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease ', AGING CELL, vol. 13, no. 1, pp. 49-59 . https://doi.org/10.1111/acel.12148
Aging Cell

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by pathological deposits of β-amyloid (Aβ) in senile plaques, intracellular neurofibrillary tangles (NFTs) comprising hyperphosphorylated aggregated tau, synaptic dysfunction an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bfb6f65bf99f99d4c1cec613cca309
https://doi.org/10.1111/acel.12148

Activity and circadian rhythm influence synaptic Shank3 protein levels in mice

Autor: Tobias M. Boeckers, Antonietta Vilella, Andreas M. Grabrucker, Resham Chhabra, Tasnuva Sarowar, Michele Zoli

Various recent studies revealed that the proteins of the Shank family act as major scaffold organizing elements in the post-synaptic density of excitatory synapses and that their expression level is able to influence synapse formation, maturation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c6e99d2ca64b6085029fc42912f5c3
https://hdl.handle.net/11380/1134142

Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses

Autor: Stefanie Pfaender, Andreas M. Grabrucker, Katharina Mangus, Tobias M. Boeckers, Resham Chhabra, Tanja Baecker

Publikováno v: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 27(4)

Recent studies suggest that synaptic pathology in autism spectrum disorder (ASD) might be caused by the disruption of a signaling pathway at excitatory glutamatergic synapses, which can be influenced by environmental factors. Some factors, such as pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c5b482772c10020382adbe83033709
https://pubmed.ncbi.nlm.nih.gov/25007851