Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Research Papers with Commentaries"'
Autor:
Gunilla Grundström, Caroline Düringer, Eylem Gürcan, Karin Fredriksson, Magnus Löfdahl, Elisabet Wieslander, David J. Nicholls, Mandy Lawson, Claes-Göran Löfdahl, Solange H Korn, Carl Magnus Sköld, Hanna Falk Håkansson, David S. Silberstein, Anders Jerre, I.A. Dainty
Publikováno v:
British Journal of Pharmacology. 158:169-179
Background and purpose: beta(2)-Adrenoceptor agonists (beta(2)-agonists) are important bronchodilators used in the treatment of asthma and chronic obstructive pulmonary disease. At the molecular level, beta(2)-adrenergic agonist stimulation induces d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8712d1f5b53b3534368f7a4900ef8a94
https://doi.org/10.1111/j.1476-5381.2009.00262.x
https://doi.org/10.1111/j.1476-5381.2009.00262.x
Autor:
Dietrich Pfeiffer, Jan Janoušek, D Rojas Gomez, S Krautblatter, Katja Blanke, Sebastian Karl, Aida Salameh, Stefan Dhein
Publikováno v:
British Journal of Pharmacology. 158:198-208
Background and purpose: In mammalian heart, connexin43 (Cx43) represents the predominant connexin in the working myocardium. As the β-adrenoceptor is involved in many cardiac diseases, we wanted to clarify the pathway by which β-adrenoceptor stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212519f7e6a3e9616d63837d69c271ec
https://doi.org/10.1111/j.1476-5381.2009.00344.x
https://doi.org/10.1111/j.1476-5381.2009.00344.x
Publikováno v:
British Journal of Pharmacology. 157:1175-1185
Background and purpose: Human pancreatic carcinoma is a highly malignant cancer. Previous studies have shown that the decoy receptor 3 (DcR3) for Fas ligand (FasL) plays significant roles in tumour progression and immune suppression. In the present s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668119eee2c4c52259363b92eb38f93e
https://doi.org/10.1111/j.1476-5381.2009.00237.x
https://doi.org/10.1111/j.1476-5381.2009.00237.x
Publikováno v:
British Journal of Pharmacology. 157:1189-1202
Background and purpose: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptotic death in a variety of cancer cells without marked toxicity to most normal cells. We previously reported that wogonin, a potent anticancer agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ec9b961e14aae474356bfa3f70ac41
https://doi.org/10.1111/j.1476-5381.2009.00245.x
https://doi.org/10.1111/j.1476-5381.2009.00245.x
Publikováno v:
British Journal of Pharmacology; Vol 166
British Journal of Pharmacology
British Journal of Pharmacology
In cardiac ventricular myocytes, an imbalance between inward and outward currents may prolong action potential duration. This makes the heart vulnerable to the occurrence of so-called torsade de pointes (TdP) arrhythmias, which are life-threatening v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b114972c3780eb08f5934eb7ff9fffb
Autor:
Kerstin Boengler
Publikováno v:
British Journal of Pharmacology. 158:195-197
In mammalian heart, connexin43 (Cx43) represents the predominant connexin in the working myocardium. As the beta-adrenoceptor is involved in many cardiac diseases, we wanted to clarify the pathway by which beta-adrenoceptor stimulation may control Cx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d599f21ab07ebb667399d5cf421800e9
https://doi.org/10.1111/j.1476-5381.2009.00372.x
https://doi.org/10.1111/j.1476-5381.2009.00372.x
Autor:
John R. Traynor, Susan L. Ingram
Publikováno v:
British Journal of Pharmacology. 158:154-156
Opioid agonists are the best therapy for moderate to severe pain, but clinical use is limited due to the development of tolerance and dependence. For the first time, Bailey and co-workers have demonstrated functional selectivity for agonist-induced d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d25139812189876174ab9d7ce30e38
https://doi.org/10.1111/j.1476-5381.2009.00198.x
https://doi.org/10.1111/j.1476-5381.2009.00198.x
Autor:
Malcolm R. Macleod, Ulrich Dirnagl
Publikováno v:
British Journal of Pharmacology
British Journal of Pharmacology; Vol 157
British Journal of Pharmacology; Vol 157
In this issue, Bath et al. use state of the art meta-analytical tools to address the pressing question of why NXY-059, a compound at the time considered to fulfil all the recommendations for the evaluation of preclinical data regarding neuroprotectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf52a62b12bacbacf840b5b0b82ecb3
https://doi.org/10.1111/j.1476-5381.2009.00211.x
https://doi.org/10.1111/j.1476-5381.2009.00211.x
Artificial agonists may have higher efficacy for receptor activation than the physiological agonist. Until now, such 'superagonism' has rarely been reported for GPCRs. Iperoxo is an extremely potent muscarinic receptor agonist. We hypothesized that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::79f45604589b4025bd0d8c420dd7b055
https://europepmc.org/articles/PMC3651661/
https://europepmc.org/articles/PMC3651661/
Autor:
Rohacs, Tibor
Transient receptor potential melastatin 7 (TRPM7) is a unique channel kinase which is crucial for various physiological functions. However, the mechanism by which TRPM7 is gated and modulated is not fully understood. To better understand how modulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8325e5caf7e87d9dce2c95568b4b6718
https://europepmc.org/articles/PMC3596636/
https://europepmc.org/articles/PMC3596636/