New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Autor: Tom Mikkelsen, Rogier Versteeg, Christelle Dufour, Jens Schittenhelm, Umut H. Toprak, Eleonora Aronica, Sariah Allen, Stefan M. Pfister, Arie Perry, Dominique Figarella-Branger, David T.W. Jones, Stephan Wolf, Irene Slavc, Christian Mawrin, Pieter Wesseling, Nada Jabado, Cynthia Cowdrey, David W. Ellison, Andreas von Deimling, Jörg Felsberg, Michael A. Grotzer, Pascale Varlet, Michael C. Frühwald, Volker Hovestadt, Timothy E. Van Meter, Gnanaprakash Balasubramanian, V. Peter Collins, Wolfram Scheurlen, Christian Hagel, Volkmar Hans, Johannes Gojo, Irina Leis, Michael D. Taylor, Catherine Keohane, Marco Prinz, Rachid Drissi, Maria Łastowska, Istvan Vajtai, Anne Jouvet, Sonika Dahiya, Marietta Wolter, Matthias Schlesner, Till Milde, Chris Jones, Pascal Johann, Kristian W. Pajtler, Anna Maria Buccoliero, Marina Ryzhova, David Scheie, Kenneth Aldape, Matija Snuderl, Martin Ebinger, Bret C. Mobley, Sebastian Brabetz, Joanna J. Phillips, Tarek Shalaby, Silvia Hofer, Christian Koelsche, Christel Herold-Mende, Barbara C. Worst, Martin U. Schuhmann, Jüri Reimand, Walter Berger, Stephan Frank, Diana Carvalho, Daniela Lötsch, Christof M. Kramm, Amar Gajjar, David Capper, Peter van Sluis, Ivo Buchhalter, Christine Haberler, Katja von Hoff, Stefan Rutkowski, Roland Eils, Martin Hasselblatt, Ulrich Schüller, Maryam Fouladi, Jochen Rößler, Guido Reifenberger, Brent A. Orr, Andrew S. Moore, Alan Mackay, Marc Remke, André O. von Bueren, Felix Sahm, Jan Koster, Karel Zitterbart, Dominik Sturm, Paul A. Northcott, Peter Lichter, Matthias A. Karajannis, Stefan Holm, Martin Sill, Wiesława Grajkowska, Stéphanie Puget, Felice Giangaspero, Marcel Kool, Reinhard Schneppenheim, Lynn Ann Forrester, Mariarita Santi, Torsten Pietsch, Camelia M. Monoranu, Richard Volckmann, Iris Fried, Matthew Schniederjan, Andrey Korshunov, Elke Pfaff, Rainer Grobholz, Jacques Grill

Publikováno v: Cell, Vol. 164, No 5 (2016) pp. 1060-1072
Cell, 164, 5, pp. 1060-72
Cell, 164(5), 1060-1072. Cell Press
Sturm, D, Orr, B A, Toprak, U H, Hovestadt, V, Jones, D T W, Capper, D, Sill, M, Buchhalter, I, Northcott, P A, Leis, I, Ryzhova, M, Koelsche, C, Pfaff, E, Allen, S J, Balasubramanian, G, Worst, B C, Pajtler, K W, Brabetz, S, Johann, P D, Sahm, F, Reimand, J, Mackay, A, Carvalho, D M, Remke, M, Phillips, J J, Perry, A, Cowdrey, C, Drissi, R, Fouladi, M, Giangaspero, F, Lastowska, M, Grajkowska, W, Scheurlen, W, Pietsch, T, Hagel, C, Gojo, J, Loetsch, D, Berger, W, Slavc, I, Haberler, C, Jouvet, A, Holm, S, Hofer, S, Prinz, M, Keohane, C, Fried, I, Mawrin, C, Scheie, D, Mobley, B C, Schniederjan, M J, Santi, M, Buccoliero, A M, Dahiya, S, Kramm, C M, von Bueren, A O, von Hoff, K, Rutkowski, S, Herold-Mende, C, Fruehwald, M C, Milde, T, Hasselblatt, M, Wesseling, P, Roessler, J, Schueller, U, Ebinger, M, Schittenhelm, J, Frank, S, Grobholz, R, Vajtai, I, Hans, V, Schneppenheim, R, Zitterbart, K, Collins, V P, Aronica, E, Varlet, P, Puget, S, Dufour, C, Grill, J, Figarella-Branger, D, Wolter, M, Schuhmann, M U, Shalaby, T, Grotzer, M, van Meter, T, Monoranu, C-M, Felsberg, J, Reifenberger, G, Snuderl, M, Forrester, L A, Koster, J, Versteeg, R, Volckmann, R, van Sluis, P, Wolf, S, Mikkelsen, T, Gajjar, A, Aldape, K, Moore, A S, Taylor, M D, Jones, C, Jabado, N, Karajannis, M A, Eils, R, Schlesner, M, Lichter, P, von Deimling, A, Pfister, S M, Ellison, D W, Korshunov, A & Kool, M 2016, ' New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs ', Cell, vol. 164, no. 5, pp. 1060-1072 . https://doi.org/10.1016/j.cell.2016.01.015
Cell
Cell, 2016, 164, pp.1060-1072. ⟨10.1016/j.cell.2016.01.015⟩
Cell, Elsevier, 2016, 164, pp.1060-1072. ⟨10.1016/j.cell.2016.01.015⟩
Cell, 164, 1060-72
Cell, 164(5), 1060. Cell Press

Item does not contain fulltext Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ce75bf4ceb1b2f119f15b978d9c6da
https://doi.org/10.1016/j.cell.2016.01.015

The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo

Autor: Tony A. Rodrigues, Aurora Barros-Barbosa, Ana G. Pedrosa, Jorge E. Azevedo, Ana F. Dias, Tânia Francisco

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

A remarkable property of the machinery for import of peroxisomal matrix proteins is that it can accept already folded proteins as substrates. This import involves binding of newly synthesized proteins by cytosolic peroxisomal biogenesis factor 5 (PEX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f48b33e77a0947decee710e624b6ca2
https://europepmc.org/articles/PMC5602389/

The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation

Autor: Séverine Carrère-Kremer, Nicolas Blondiaux, Alexandre Wohlkonig, Laurent Kremer, Alain R. Baulard, Virginie Molle, Jade Leiba, Martin Moune Dimala

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, 2014, 446 (4), pp.1132-1138. ⟨10.1016/j.bbrc.2014.03.074⟩
Biochemical and Biophysical Research Communications, Elsevier, 2014, 446 (4), pp.1132-1138. ⟨10.1016/j.bbrc.2014.03.074⟩

International audience; Recent efforts have underlined the role of Serine/Threonine Protein Kinases (STPKs) in growth, pathogenesis and cell wall metabolism in mycobacteria. Herein, we demonstrated that the Mycobacterium tuberculosis EthR, a transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbce88c9d281dbbcdc7c0e7fab59cd56
https://doi.org/10.1016/j.bbrc.2014.03.074

The LIM-only protein FHL2 is a negative regulator of E4F1

Autor: Matthieu Lacroix, Eric Julien, Claude Sardet, I Iankova, Conception Paul, L Le Cam, Yu Wei, C Labalette, A Le Cam, Beat W. Schäfer

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2006, 25 (40), pp.5475--84. ⟨10.1038/sj.onc.1209567⟩
Oncogene, 2006, 25 (40), pp.5475--84. ⟨10.1038/sj.onc.1209567⟩

The E1A-targeted transcription factor E4F1 is a key player in the control of mammalian embryonic and somatic cell proliferation and survival. Mouse embryos lacking E4F die at an early developmental stage, whereas enforced expression of E4F1 in variou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c922941197396982d26cba160dcf8764
https://hal.archives-ouvertes.fr/hal-02262467

Functional domains involved in the interaction between Orc1 and transcriptional repressor AlF-C that bind to an origin/promoter of the rat aldolase B gene

Autor: Yasushi Saitoh, Hiroyoshi Ariga, Ken-ichi Tsutsumi, Satoru Miyagi

The promoter of the rat aldolase B (AldB) gene functions in vivo as an origin of DNA replication in the cells in which transcription of the gene is repressed. Previously, we identified two closely related DNA-binding proteins, AlF-C1 and AlF-C2, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e416cd5fedc57394e73739cf93c12e12
https://europepmc.org/articles/PMC137957/