Výsledky vyhledávání - "Repressor Proteins/physiology"

REST represses a subset of the pancreatic endocrine differentiation program

Autor: Yung Hae Kim, Jacques-Antoine Haefliger, Chai An Mao, Anne Grapin-Botton, David Martin, Dror Sever

Publikováno v: Developmental Biology, vol. 405, no. 2, pp. 316-327
Developmental biology

To contribute to devise successful beta-cell differentiation strategies for the cure of Type 1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b56bf5e0c72b260fda4d146f46f850

Zobrazit plný text záznamu

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

Autor: Davide, Pozzi, Gabriele, Lignani, Enrico, Ferrea, Andrea, Contestabile, Francesco, Paonessa, Rosalba, D'Alessandro, Pellegrino, Lippiello, Davide, Boido, Anna, Fassio, Jacopo, Meldolesi, Flavia, Valtorta, Fabio, Benfenati, Pietro, Baldelli

Intrinsic homeostasis enables neuronal circuits to maintain activity levels within an appropriate range by modulating neuronal voltage-gated conductances, but the signalling pathways involved in this process are largely unknown. We characterized the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac54b6a1a66ef36bb61b91d4861133a6
http://hdl.handle.net/11567/694772

Zobrazit plný text záznamu

Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box

Autor: Katharina Laubner, AE Mehana, Claes B. Wollheim, M Alt, Eleni Tsaroucha, Natalie Rimmer, Despoina Danassi, Nikolaos Perakakis, Jochen Seufert, Günter Päth, Haiyan Wang

Publikováno v: Molecular and Cellular Endocrinology, Vol. 363, No 1-2 (2012) pp. 20-6

Human Kruppel-like factor 11 (hKLF11) has been characterised to both activate and inhibit human insulin promoter (hInsP) activity. Since KLF11 is capable to differentially regulate genes dependent on recruited cofactors, we investigated the effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122cbc48de83c06d7e10a5e2162119ce
https://archive-ouverte.unige.ch/unige:33355

Zobrazit plný text záznamu

Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels

Autor: Yessoufou, A., Wahli, W.

Publikováno v: Swiss Medical Weekly, vol. 140, pp. w13071

Chronic disorders, such as obesity, diabetes, inflammation, non-alcoholic fatty liver disease and atherosclerosis, are related to alterations in lipid and glucose metabolism, in which peroxisome proliferator-activated receptors (PPAR)α, PPARβ/δ an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::13cfd2da6220853c134686d1acde641b
https://serval.unil.ch/notice/serval:BIB_31B922B23A31

Zobrazit plný text záznamu

Ureter myogenesis: putting Teashirt into context

Autor: Laurent Fasano, Claire M. Lye, Adrian S. Woolf

Publikováno v: Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, 2010, 21 (1), pp.24-30. ⟨10.1681/ASN.2008111206⟩
Journal of the American Society of Nephrology, American Society of Nephrology, 2010, 21 (1), pp.24-30. ⟨10.1681/ASN.2008111206⟩

After the basic shape of the mammalian ureter is established, its epithelia mature and a coat of smooth muscle cells differentiate around nascent urothelia. The ureter actively propels tubular fluid from the renal pelvis to the bladder, and this peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9fdaa6aa9f4505f44c41c1fb89cf0c
https://pubmed.ncbi.nlm.nih.gov/19926888

Zobrazit plný text záznamu

Pax6 Regulates the Proglucagon Processing Enzyme PC2 and Its Chaperone 7B2▿ †

Autor: Jacques Philippe, Liora S. Katz, Yvan Gosmain, Eric Marthinet

Publikováno v: Molecular and Cellular Biology, Vol. 29, No 8 (2009) pp. 2322-2334

Pax6 is important in the development of the pancreas and was previously shown to regulate pancreatic endocrine differentiation, as well as the insulin, glucagon, and somatostatin genes. Prohormone convertase 2 (PC2) is the main processing enzyme in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c5236d1e1c8118fb84053c76a0e1dc
https://europepmc.org/articles/PMC2663301/

Zobrazit plný text záznamu

Clostridium difficile toxin synthesis is negatively regulated by TcdC

Autor: Revathi Govind, Ana Antunes, Susana Matamouros, Bruno Dupuy

Publikováno v: Journal of Medical Microbiology
Journal of Medical Microbiology, 2008, 57 (6), pp.685-689. ⟨10.1099/jmm.0.47775-0⟩
Journal of Medical Microbiology, Society for General Microbiology, 2008, 57 (6), pp.685-689. ⟨10.1099/jmm.0.47775-0⟩

Clostridium difficile toxin synthesis is growth phase-dependent and is regulated by various environmental signals. The toxin genes tcdA and tcdB are located in a pathogenicity locus, which also includes three accessory genes, tcdR, tcdC and tcdE. Tcd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5065ea629ee864e3cd422b757926d6e
https://pubmed.ncbi.nlm.nih.gov/18480323

Zobrazit plný text záznamu

COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells

Autor: Mark Leid, Sylvette Chasserot-Golaz, Olivier Rohr, Laetitia Redel, Céline Marban, Stella Suzanne, Evelyne Schaeffer, Dominique Lecestre, Dominique Aunis, Carine Van Lint

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2005, 33 (7), ⟨10.1093/nar/gki529⟩
Nucleic acids research, 33 (7

Human immunodeficiency virus type 1 (HIV-1) gene transcription is characterized by two temporally distinct phases. While the initial phase relies solely on cellular transcription factors, the subsequent phase is activated by the viral Tat transactiva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cf07bb5f28ac6ae1258c530709e36d

Zobrazit plný text záznamu

The RheA repressor is the thermosensor of the HSP18 heat shock response in Streptomyces albus

Autor: Pascale Servant, Philippe Mazodier, Cosette Grandvalet

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2000, 97 (7), pp.3538-3543. ⟨10.1073/pnas.97.7.3538⟩
Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (7), pp.3538-3543. ⟨10.1073/pnas.97.7.3538⟩

Microorganisms have mechanisms to sense their environment and rapidly adapt to survive changes in conditions. In Streptomyces albus , various transcriptional repressors mediate the induction of heat shock genes. The RheA repressor regulates the synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f82583848d455ccd52d5b9481f688d4
https://hal.archives-ouvertes.fr/hal-03140180

Zobrazit plný text záznamu

SOX5 Controls the Sequential Generation of Distinct Corticofugal Neuron Subtypes

Autor: Denis Jabaudon, Paola Arlotta, Eiman Azim, Jeffrey D. Macklis, Tina Lai, Joao R.L. Menezes, Bradley J. Molyneaux

Publikováno v: Neuron, Vol. 57, No 2 (2008) pp. 232-47

SummaryThe molecular mechanisms controlling the development of distinct subtypes of neocortical projection neurons, and CNS neuronal diversity more broadly, are only now emerging. We report that the transcription factor SOX5 controls the sequential g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb88f31717a04149b5491d397ac3462
https://doi.org/10.1016/j.neuron.2008.02.001

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání