Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Replication fork arrest"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2002 Dec . 99(26), 16887-16892.
Externí odkaz:
https://www.jstor.org/stable/3074033
Publikováno v:
Genome Instability & Disease. 2:263-280
Human cells need to cope with the stalling of DNA replication to complete replication of the entire genome to minimize genome instability. They respond to “replication stress” by activating the conserved ATR-Claspin-Chk1 replication checkpoint pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8bb2296ac02f06bf0130d38fb693c21
https://doi.org/10.1007/s42764-021-00049-8
https://doi.org/10.1007/s42764-021-00049-8
Autor:
Masatoshi Fujita, Kazumasa Yoshida
Publikováno v:
Cellular and Molecular Life Sciences. 78:6763-6773
During duplication of the genome, eukaryotic cells may experience various exogenous and endogenous replication stresses that impede progression of DNA replication along chromosomes. Chemical alterations in template DNA, imbalances of deoxynucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bf772131bf738ac27a0d7578167d727
https://doi.org/10.1007/s00018-021-03926-3
https://doi.org/10.1007/s00018-021-03926-3
Publikováno v:
Genetics
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
DNA replication forks that are stalled by DNA damage activate an S-phase checkpoint that prevents irreversible fork arrest and cell death. The increased cell death caused by DNA damage in budding yeast cells lacking the Rad53 checkpoint protein kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11f2c4e82f5fae57e7d3b2c34bef39b
http://europepmc.org/articles/PMC6366903
http://europepmc.org/articles/PMC6366903
Publikováno v:
Molecular Genetics and Genomics. 295:695-703
Fission yeast Cds1 is responsible for the replication checkpoint activation and helps to protect replication fork collapse in response to hydroxyurea (HU). Here, we investigated the role of histone deacetylase in response to replication fork arrest a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9847fb8c845717ae4a7de03e776d9ed2
https://doi.org/10.1007/s00438-020-01655-z
https://doi.org/10.1007/s00438-020-01655-z
Transcription Termination Factor 1 (TTF1) is an essential mammalian protein that regulates cellular transcription, replication fork arrest, DNA damage repair, chromatin remodelling etc. TTF1 interacts with numerous cellular proteins to regulate vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50aabecaa8bbcc36e5bc1a09fe62d59a
https://doi.org/10.1101/2021.11.11.468186
https://doi.org/10.1101/2021.11.11.468186
Publikováno v:
Molecular and Cellular Biology
Regulation of replication origins is important for complete duplication of the genome, but the effect of origin activation on the cellular response to replication stress is poorly understood. The budding yeast rRNA gene (rDNA) forms tandem repeats an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34b9349ab75a70bd0424312b62df89b
https://pubmed.ncbi.nlm.nih.gov/33619126
https://pubmed.ncbi.nlm.nih.gov/33619126
Autor:
Jonathan D. Licht, Daphné Dupéré-Richer, Huanzhou Xu, Kartika Venugopal, Yang Feng, Richard L. Bennett, Brian K. Law, Heidi L. Casellas Roman, Luisa M Posada, Alberto Riva, Rene Opavsky, Daniil Shabashvili, Kathryn I. Krajcik, Prabhjot Kaur, Chamara Gunaratne, Pawel Nowialis, Christopher R. Cogle, Zachary Zaroogian, Santhi Pondugula, Jianping Li, Jonathan E. Bird, Christina Taragjini, Philipp B. Staber, Olga A. Guryanova, Sumita Bhaduri-McIntosh, Stefan Kubicek, Cassandra M. Berntsen
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(4)
Purpose: In acute myeloid leukemia (AML), recurrent DNA methyltransferase 3A (DNMT3A) mutations are associated with chemoresistance and poor prognosis, especially in advanced-age patients. Gene-expression studies in DNMT3A-mutated cells identified si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f516224dea57cb8a1b957558b4c2bcc6
https://pubmed.ncbi.nlm.nih.gov/34880109
https://pubmed.ncbi.nlm.nih.gov/34880109
Autor:
Andrew D. Ellington, Peter J. Enyeart, Casey J. Toft, Jiri Perutka, Morgane J. J. Moreau, Patrick M. Schaeffer, Savitri Mandapati, Alanna E. Sorenson
InEscherichia coli, DNA replication termination is orchestrated by two clusters ofTersites forming a DNA replication fork trap when bound by Tus proteins. The formation of a ‘locked’ Tus-Tercomplex is essential for halting incoming DNA replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::419d268c72d4b54c5cc6af112b64c07c
https://doi.org/10.1101/2021.07.20.453168
https://doi.org/10.1101/2021.07.20.453168
Autor:
Santhi Pondugula, Brian K. Law, C. Taragjini, Pawel Nowialis, Stefan Kubicek, Cassandra M. Berntsen, Jennifer W Li, Chamara Gunaratne, Philipp B. Staber, Kartika Venugopal, Daniil Shabashvili, Olga A. Guryanova, Luisa M Posada, Yang Feng, Richard L. Bennett, Kathryn I. Krajcik, Zachary Zaroogian, Jonathan E. Bird, H. L. Casellas-Roman, Christopher R. Cogle, Alberto Riva, Rene Opavsky, Daphné Dupéré-Richer, Jonathan D. Licht
Mutations in the DNA methyltransferase 3A (DNMT3A) gene are recurrent in de novo acute myeloid leukemia (AML) and are associated with resistance to standard chemotherapy, disease relapse, and poor prognosis, especially in advanced-age patients. Previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb17d225c80d17824ed4120ca03f89cb
https://doi.org/10.1101/2021.05.28.445639
https://doi.org/10.1101/2021.05.28.445639