Potency by design: Novel insights in transfection and purification for manufacturing of rAAV gene therapy vectors

Autor: Maccani, Andreas ¹, Pachlinger, Robert ¹, Eisenhut, Peter, Unterthurner, Sabine, Heider, Susanne, Repik, Christoph, Reuberger, Stefan, Andorfer, Peter, Lengler, Johannes, Kinastberger, Bernhard, Seczer, Dieter, Gruber, Petra, Apschner, Alexander ^⁎, Micutkova, Lucia ^⁎

Publikováno v: In Journal of Biotechnology February 2025 398:127-132

Potency by design: Novel insights in transfection and purification for manufacturing of rAAV gene therapy vectors.

Autor: Maccani A; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Pachlinger R; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Eisenhut P; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Unterthurner S; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Heider S; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Repik C; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Reuberger S; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Andorfer P; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Lengler J; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Kinastberger B; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Seczer D; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Gruber P; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria., Apschner A; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria. Electronic address: alexander.apschner@takeda.com., Micutkova L; Gene Therapy Process Development, Baxalta Innovations GmbH, part of Takeda companies, Orth an der Donau, 2304 Orth an der Donau, Austria. Electronic address: lucia.micutkova@yahoo.com.

Publikováno v: Journal of biotechnology [J Biotechnol] 2024 Dec 17; Vol. 398, pp. 127-132. Date of Electronic Publication: 2024 Dec 17.